GHRL and AGRP

Number of citations of the paper that reports this interaction (PubMedID 11196643)
0

Data Source:
HPRD (in vivo)

		GHRL	AGRP
Description		ghrelin and obestatin prepropeptide	agouti related neuropeptide
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Axon Secretory Granule Lumen Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse Neuronal Dense Core Vesicle Lumen	Extracellular Region Extracellular Space Golgi Apparatus Golgi Lumen Neuronal Cell Body
	Molecular Function	G Protein-coupled Receptor Binding Hormone Activity Protein Binding Growth Hormone-releasing Hormone Activity Protein Tyrosine Kinase Activator Activity Ghrelin Receptor Binding	Signaling Receptor Binding Neuropeptide Hormone Activity Type 1 Melanocortin Receptor Binding
	Biological Process	Gastric Acid Secretion Negative Regulation Of Endothelial Cell Proliferation G Protein-coupled Receptor Internalization Glucose Metabolic Process G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Synapse Assembly Actin Polymerization Or Depolymerization Adult Feeding Behavior Response To Hormone Hormone-mediated Signaling Pathway Dendrite Development Negative Regulation Of Angiogenesis Growth Hormone Secretion Response To Nutrient Levels Positive Regulation Of Insulin Secretion Regulation Of Response To Food Positive Regulation Of Response To Food Positive Regulation Of Appetite Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Growth Rate Negative Regulation Of Locomotion Positive Regulation Of Multicellular Organism Growth Regulation Of Cell Population Proliferation Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Negative Regulation Of Apoptotic Process Cortisol Secretion Positive Regulation Of MAPK Cascade Response To Estrogen Positive Regulation Of Growth Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Insulin Secretion Decidualization Negative Regulation Of Inflammatory Response Cartilage Development Positive Regulation Of Corticotropin Secretion Positive Regulation Of Cortisol Secretion Response To Electrical Stimulus Positive Regulation Of Synapse Assembly Regulation Of Transmission Of Nerve Impulse Excitatory Postsynaptic Potential Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Growth Hormone Receptor Signaling Pathway Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynapse Organization Positive Regulation Of Small Intestinal Transit Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Bone Development Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Eating Behavior Positive Regulation Of Adipose Tissue Development Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Positive Regulation Of Gastric Mucosal Blood Circulation Positive Regulation Of Small Intestine Smooth Muscle Contraction Regulation Of Gastric Motility Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Feeding Behavior	Neuropeptide Signaling Pathway Circadian Rhythm Feeding Behavior Adult Feeding Behavior Hormone-mediated Signaling Pathway Response To Insulin Eating Behavior Long-day Photoperiodism Maternal Process Involved In Female Pregnancy Regulation Of Feeding Behavior Positive Regulation Of Feeding Behavior
Pathways			FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) ghrelin levels ( 33852427)	Blood protein levels ( 30072576) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278)
Interacting Genes		9 interacting genes: ACE2 AGRP GHRHR GHSR LEP MLNR NPY UBQLN1 UBQLN2	4 interacting genes: GHRL MC3R MC4R MC5R
Entrez ID		51738	181
HPRD ID		05638	09079
Ensembl ID		ENSG00000157017	ENSG00000159723
Uniprot IDs		Q9UBU3	C6SUN5 O00253
PDB IDs		6H3E 7F9Y 7NA7 7W2Z	1HYK 1MR0
Enriched GO Terms of Interacting Partners?		Adult Feeding Behavior Feeding Behavior Positive Regulation Of Behavior Positive Regulation Of Feeding Behavior Regulation Of Behavior Regulation Of Response To Food Regulation Of Appetite Regulation Of Feeding Behavior Growth Hormone-releasing Hormone Receptor Activity Regulation Of Response To Nutrient Levels Adult Behavior Positive Regulation Of Eating Behavior Positive Regulation Of Response To Food Positive Regulation Of Appetite Response To Insulin Growth Hormone Secretion Regulation Of Eating Behavior Peptide Hormone Secretion Regulation Of Transport Peptide Secretion Regulation Of Amine Transport Hormone Secretion Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Appetite Response To Peptide Hormone Regulation Of Growth Hormone Secretion Cellular Response To Insulin Stimulus Peptide Transport Hormone Transport Hormone Binding Positive Regulation Of ERAD Pathway G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Amide Transport Regulation Of Defense Response Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Transport Regulation Of ERAD Pathway Signal Release Positive Regulation Of Developmental Growth Photoperiodism Regulation Of Blood Pressure Neuropeptide Hormone Activity Cellular Response To Peptide Hormone Stimulus Eating Behavior Maternal Process Involved In Female Pregnancy Positive Regulation Of Multicellular Organism Growth Hormone Metabolic Process Determination Of Adult Lifespan Positive Regulation Of Multicellular Organismal Process	Melanocortin Receptor Activity Regulation Of Feeding Behavior Melanocyte-stimulating Hormone Receptor Activity Regulation Of Behavior Regulation Of Eating Behavior Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Neuropeptide Binding G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Peptide Hormone Secretion Peptide Secretion Feeding Behavior Hormone Transport Hormone Secretion Peptide Transport Ghrelin Receptor Binding Cortisol Secretion Positive Regulation Of Gastric Mucosal Blood Circulation Homoiothermy Amide Transport Response To Melanocyte-stimulating Hormone Growth Hormone-releasing Hormone Activity Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Small Intestinal Transit Positive Regulation Of Growth Rate Signal Release Positive Regulation Of Small Intestine Smooth Muscle Contraction Positive Regulation Of Bone Development Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Eating Behavior Positive Regulation Of Cortisol Secretion Positive Regulation Of Response To Food Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Appetite Regulation Of Gastric Motility Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Neuronal Dense Core Vesicle Lumen Regulation Of Growth Rate Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Regulation Of Blood Circulation Growth Hormone Secretion Positive Regulation Of Corticotropin Secretion Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Corticotropin Secretion Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Gastric Acid Secretion Positive Regulation Of Growth Hormone Secretion
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