GHRL and MLNR

Number of citations of the paper that reports this interaction (PMID 12606621)
9

Data Source:
HPRD (in vitro)

		GHRL	MLNR
Gene Name		ghrelin/obestatin prepropeptide	motilin receptor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Axon Secretory Granule Lumen	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G-protein Coupled Receptor Binding Growth Hormone-releasing Hormone Activity Protein Tyrosine Kinase Activator Activity Ghrelin Receptor Binding	G-protein Coupled Receptor Activity Growth Hormone-releasing Hormone Receptor Activity
	Biological Process	Activation Of MAPK Activity Gastric Acid Secretion Negative Regulation Of Endothelial Cell Proliferation Glucose Metabolic Process G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Actin Polymerization Or Depolymerization Adult Feeding Behavior Response To Hormone Hormone-mediated Signaling Pathway Dendrite Development Negative Regulation Of Angiogenesis Growth Hormone Secretion Positive Regulation Of Insulin Secretion Regulation Of Response To Food Positive Regulation Of Appetite Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Locomotion Positive Regulation Of Multicellular Organism Growth Regulation Of Cell Proliferation Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Negative Regulation Of Apoptotic Process Cortisol Secretion Response To Estrogen Cellular Protein Metabolic Process Negative Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Insulin Secretion Decidualization Negative Regulation Of Inflammatory Response Cartilage Development Positive Regulation Of Corticotropin Secretion Positive Regulation Of Cortisol Secretion Positive Regulation Of Synapse Assembly Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity	G-protein Coupled Receptor Signaling Pathway Digestion
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ACE2 AGRP GHRHR GHSR LEP MLNR NPY UBQLN1	4 interactors: GHRHR GHRL GPRASP1 MLN
Entrez ID		51738	2862
HPRD ID		05638	04197
Ensembl ID		ENSG00000157017	ENSG00000102539
Uniprot IDs		Q9UBU3	O43193
PDB IDs		1P7X
Enriched GO Terms of Interacting Partners?		Adult Feeding Behavior Feeding Behavior Regulation Of Response To Food Regulation Of Appetite Adult Behavior Behavior Female Pregnancy Positive Regulation Of Appetite Regulation Of Hormone Levels Peptide Hormone Secretion Peptide Secretion Response To Insulin Maternal Process Involved In Female Pregnancy Multicellular Organismal Reproductive Process Hormone Secretion Multicellular Organism Reproduction Hormone Transport Peptide Transport Growth Hormone Secretion Digestion Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Reproduction Single-organism Behavior Response To Peptide Hormone Amide Transport Response To Peptide G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Developmental Growth Regulation Of Blood Pressure Cellular Response To Hormone Stimulus Hormone Metabolic Process Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Reproductive Process Regulation Of Peptide Hormone Secretion Eating Behavior Positive Regulation Of Growth Regulation Of Hormone Secretion Negative Regulation Of Peptide Secretion Response To Organonitrogen Compound Regulation Of Developmental Growth Cell Surface Receptor Signaling Pathway Blood Circulation Cell-cell Signaling Positive Regulation Of Multicellular Organism Growth Response To Hormone Regulation Of Vasoconstriction Negative Regulation Of Hormone Secretion Response To Stimulus Regulation Of Protein Metabolic Process Response To Nutrient Levels	Positive Regulation Of Growth Hormone Secretion Regulation Of Growth Hormone Secretion Growth Hormone Secretion Positive Regulation Of Multicellular Organism Growth Peptide Hormone Secretion Peptide Secretion Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Hormone Secretion Hormone Transport Peptide Transport Regulation Of Multicellular Organism Growth Positive Regulation Of Hormone Secretion Cortisol Secretion Amide Transport Cell-cell Signaling Positive Regulation Of Developmental Growth Somatotropin Secreting Cell Development Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep G-protein Coupled Receptor Catabolic Process G-protein Coupled Receptor Signaling Pathway Response To Estrogen Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of Peptide Hormone Secretion Positive Regulation Of Growth Positive Regulation Of Cortisol Secretion Positive Regulation Of Corticotropin Secretion Positive Regulation Of Appetite Regulation Of Hormone Secretion Regulation Of Hormone Levels Regulation Of Corticotropin Secretion Regulation Of Growth Hormone Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Somatotropin Secreting Cell Differentiation Regulation Of Developmental Growth Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle, REM Sleep Negative Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Secretion Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Adult Feeding Behavior Gastric Acid Secretion Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Establishment Of Localization In Cell Response To Steroid Hormone Adenohypophysis Development Negative Regulation Of Interleukin-1 Beta Production Secretion By Cell Regulation Of Circadian Sleep/wake Cycle, Sleep
Tagcloud ?		breeding broiler bw bw49 bw70 bwg chickens desorption fcr feed fi flight genotyped ghrelin ghsr haplotypes igf1r maldi meanwhile rs14011776 rs14011780 rs14011783 rs14678932 rs14986828 rs15675065 rs15675067 rs16675844 snps yellow
Tagcloud (Difference) ?		breeding broiler bw bw49 bw70 bwg chickens desorption fcr feed fi flight genotyped ghrelin ghsr haplotypes igf1r maldi meanwhile rs14011776 rs14011780 rs14011783 rs14678932 rs14986828 rs15675065 rs15675067 rs16675844 snps yellow
Tagcloud (Intersection) ?