GHRL and ACE2

Number of citations of the paper that reports this interaction (PMID 11815627)
122

Data Source:
HPRD (in vitro)

		GHRL	ACE2
Gene Name		ghrelin/obestatin prepropeptide	angiotensin I converting enzyme 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Axon Secretory Granule Lumen	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Cell Surface Integral Component Of Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	G-protein Coupled Receptor Binding Growth Hormone-releasing Hormone Activity Protein Tyrosine Kinase Activator Activity Ghrelin Receptor Binding	Virus Receptor Activity Glycoprotein Binding Endopeptidase Activity Carboxypeptidase Activity Protein Binding Metallopeptidase Activity Peptidyl-dipeptidase Activity Zinc Ion Binding Peptide Hormone Binding
	Biological Process	Activation Of MAPK Activity Gastric Acid Secretion Negative Regulation Of Endothelial Cell Proliferation Glucose Metabolic Process G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Actin Polymerization Or Depolymerization Adult Feeding Behavior Response To Hormone Hormone-mediated Signaling Pathway Dendrite Development Negative Regulation Of Angiogenesis Growth Hormone Secretion Positive Regulation Of Insulin Secretion Regulation Of Response To Food Positive Regulation Of Appetite Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Locomotion Positive Regulation Of Multicellular Organism Growth Regulation Of Cell Proliferation Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Negative Regulation Of Apoptotic Process Cortisol Secretion Response To Estrogen Cellular Protein Metabolic Process Negative Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Insulin Secretion Decidualization Negative Regulation Of Inflammatory Response Cartilage Development Positive Regulation Of Corticotropin Secretion Positive Regulation Of Cortisol Secretion Positive Regulation Of Synapse Assembly Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity	Regulation Of Cytokine Production Angiotensin Maturation Angiotensin Catabolic Process In Blood Angiotensin-mediated Drinking Behavior Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Proteolysis Response To Virus Regulation Of Vasoconstriction Receptor Biosynthetic Process Regulation Of Cell Proliferation Regulation Of Vasodilation Cellular Protein Metabolic Process Viral Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Regulation Of Inflammatory Response Maternal Process Involved In Female Pregnancy Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			Peptide hormone metabolism Metabolism of Angiotensinogen to Angiotensins
Drugs			Moexipril Lisinopril
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ACE2 AGRP GHRHR GHSR LEP MLNR NPY UBQLN1	3 interactors: AGT GHRL NTS
Entrez ID		51738	59272
HPRD ID		05638	02274
Ensembl ID		ENSG00000157017	ENSG00000130234
Uniprot IDs		Q9UBU3	Q9BYF1
PDB IDs		1P7X	1R42 1R4L 1XJP 2AJF 3D0G 3D0H 3D0I 3KBH 3SCI 3SCJ
Enriched GO Terms of Interacting Partners?		Adult Feeding Behavior Feeding Behavior Regulation Of Response To Food Regulation Of Appetite Adult Behavior Behavior Female Pregnancy Positive Regulation Of Appetite Regulation Of Hormone Levels Peptide Hormone Secretion Peptide Secretion Response To Insulin Maternal Process Involved In Female Pregnancy Multicellular Organismal Reproductive Process Hormone Secretion Multicellular Organism Reproduction Hormone Transport Peptide Transport Growth Hormone Secretion Digestion Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Reproduction Single-organism Behavior Response To Peptide Hormone Amide Transport Response To Peptide G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Developmental Growth Regulation Of Blood Pressure Cellular Response To Hormone Stimulus Hormone Metabolic Process Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Reproductive Process Regulation Of Peptide Hormone Secretion Eating Behavior Positive Regulation Of Growth Regulation Of Hormone Secretion Negative Regulation Of Peptide Secretion Response To Organonitrogen Compound Regulation Of Developmental Growth Cell Surface Receptor Signaling Pathway Blood Circulation Cell-cell Signaling Positive Regulation Of Multicellular Organism Growth Response To Hormone Regulation Of Vasoconstriction Negative Regulation Of Hormone Secretion Response To Stimulus Regulation Of Protein Metabolic Process Response To Nutrient Levels	Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Multicellular Organism Growth Regulation Of Protein Tyrosine Kinase Activity Regulation Of Blood Vessel Size Regulation Of Tube Size Negative Regulation Of Angiogenesis Feeding Behavior Regulation Of Multicellular Organism Growth Uterine Smooth Muscle Contraction Cortisol Secretion Angiotensin Mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Developmental Growth Regulation Of Peptidyl-tyrosine Phosphorylation Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Positive Regulation Of Protein Kinase C Activity Catenin Import Into Nucleus Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Renal Response To Blood Flow Involved In Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure Regulation Of Angiogenesis Positive Regulation Of Growth Female Pregnancy Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Angiotensin-mediated Drinking Behavior Smooth Muscle Cell Proliferation Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of NAD(P)H Oxidase Activity Positive Regulation Of Extracellular Matrix Constituent Secretion G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Ovarian Follicle Rupture Regulation Of Renal Output By Angiotensin Regulation Of Hormone Levels Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Inflammatory Response Regulation Of Developmental Growth Positive Regulation Of Appetite Positive Regulation Of Cortisol Secretion Positive Regulation Of Corticotropin Secretion Fibroblast Proliferation Astrocyte Activation Renin-angiotensin Regulation Of Aldosterone Production Blood Circulation Positive Regulation Of Secretion Regulation Of Corticotropin Secretion Regulation Of Growth Hormone Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Regulation Of Blood Vessel Size By Renin-angiotensin Negative Regulation Of Interleukin-6 Biosynthetic Process Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Tagcloud ?		breeding broiler bw bw49 bw70 bwg chickens desorption fcr feed fi flight genotyped ghrelin ghsr haplotypes igf1r maldi meanwhile rs14011776 rs14011780 rs14011783 rs14678932 rs14986828 rs15675065 rs15675067 rs16675844 snps yellow	aav adeno blunt blunted blunts bp contribution cre doca floxed gfp hace2 harboring hypertension icv infused neurogenic nt paraventricular pvn recombinase salt sfo sham sl subfornical transgene transgenic tudca
Tagcloud (Difference) ?		breeding broiler bw bw49 bw70 bwg chickens desorption fcr feed fi flight genotyped ghrelin ghsr haplotypes igf1r maldi meanwhile rs14011776 rs14011780 rs14011783 rs14678932 rs14986828 rs15675065 rs15675067 rs16675844 snps yellow	aav adeno blunt blunted blunts bp contribution cre doca floxed gfp hace2 harboring hypertension icv infused neurogenic nt paraventricular pvn recombinase salt sfo sham sl subfornical transgene transgenic tudca
Tagcloud (Intersection) ?