PTPRF and HSPA9

Number of citations of the paper that reports this interaction (PubMedID 25458010)
51

Data Source:
BioGRID (two hybrid)

		PTPRF	HSPA9
Description		protein tyrosine phosphatase receptor type F	heat shock protein family A (Hsp70) member 9
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Neuron Projection Neuronal Cell Body Extracellular Exosome	SAM Complex Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Inner Membrane TIM23 Mitochondrial Import Inner Membrane Translocase Complex Mitochondrial Matrix Focal Adhesion Mitochondrial Nucleoid Extracellular Exosome MIB Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Heparin Binding Hydrolase Activity Chondroitin Sulfate Proteoglycan Binding Protein-containing Complex Binding Cell Adhesion Molecule Binding	Nucleotide Binding RNA Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Cell Adhesion Signal Transduction Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Nervous System Development Regulation Of Neuron Projection Development Cell Migration Neuron Projection Regeneration Peptidyl-tyrosine Dephosphorylation Regulation Of Axon Regeneration Synaptic Membrane Adhesion Negative Regulation Of Receptor Binding	Protein Folding Protein Export From Nucleus Intracellular Protein Transport Inner Mitochondrial Membrane Organization Iron-sulfur Cluster Assembly Erythrocyte Differentiation Calcium Import Into The Mitochondrion Protein Refolding Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Erythrocyte Differentiation Negative Regulation Of Erythrocyte Differentiation Negative Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Hemopoiesis
Pathways		Receptor-type tyrosine-protein phosphatases Insulin receptor recycling Synaptic adhesion-like molecules	Mitochondrial protein import Regulation of HSF1-mediated heat shock response Complex I biogenesis Cristae formation Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt) Complex III assembly
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Attention deficit hyperactivity disorder ( 33495439 30478444) Attention deficit hyperactivity disorder or cannabis use ( 30610198) Autism spectrum disorder or schizophrenia ( 28540026) Coffee consumption ( 31046077) Cognitive ability (MTAG) ( 29186694) Disruptive behavior disorder and attention deficit hyperactivity disorder ( 33495439) Educational attainment ( 27046643) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Household income (MTAG) ( 31844048) Intake of total sugars ( 31005972) Intelligence (MTAG) ( 29326435) Mean reticulocyte volume ( 32888494) Refractive error ( 32231278) Schizophrenia ( 30285260 29483656 28991256 25056061) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Urate levels ( 31578528)	Autism spectrum disorder or schizophrenia ( 28540026) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Schizophrenia ( 25056061 29483656)
Interacting Genes		59 interacting genes: ACAN ACAT1 ACTB ARHGEF11 ARHGEF12 ARHGEF2 ATP5F1A BCAR1 CAV1 CBR1 CDH1 CREBBP CTNNB1 DEPDC1B DIAPH1 EEF1A1 EEF1G FRS2 FYN GALNT1 GAPDH GPC4 HSP90AA1 HSPA1A HSPA1L HSPA5 HSPA8 HSPA9 INSR IRS1 IRS2 JUP LACTB LCK LDHA LDHB NCAN NID1 OMG PPFIA1 PPFIA2 PPFIA3 PRPF40A PTPRA PTPRD PTPRZ1 RAP1GDS1 RET RHOA ROCK2 SEMG1 SEMG2 SEPTIN9 SKIL SOWAHC TRIO TUBA1B VCAN ZNF512B	31 interacting genes: APP DNAJC19 DNLZ ERBB2 ERCC6 FGF1 HSP90B1 HSPBP1 LAMTOR5 LCOR LINC01554 LSM8 MATK MVD NEDD8 NELFB OGT PTPN11 PTPRF RNF10 RNF26 SIRPA STUB1 SUMO2 SUMO4 SUPT6H TP53 USP7 XPO1 YKT6 YWHAG
Entrez ID		5792	3313
HPRD ID		01552	02770
Ensembl ID		ENSG00000142949	ENSG00000113013
Uniprot IDs		G1UI20 P10586	A0A384P5G6 P38646
PDB IDs		1LAR 2DJU 2DN7 2EDX 2EDY 2YD5 2YD8 4N5U 6KR4 6TPT 6TPU 6TPV 6TPW	3N8E 4KBO 6NHK 6P2U 6PMT 9BLS 9BLT 9BLU
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Protein Refolding Phosphatidylinositol 3-kinase Binding ATP-dependent Protein Folding Chaperone Focal Adhesion Perineuronal Net Disordered Domain Specific Binding Protein Folding Chaperone Cell Adhesion Regulation Of Developmental Process Regulation Of Cellular Component Organization Regulation Of Protein Localization Cellular Response To Indole-3-methanol Tau Protein Binding Response To Indole-3-methanol Lysosomal Lumen Regulation Of Cell Motility Regulation Of Cell Communication Regulation Of Signaling Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Cell Motility Regulation Of Locomotion Cadherin Binding Regulation Of Signal Transduction Apical Junction Complex Regulation Of Intracellular Signal Transduction Regulation Of Cell Differentiation Regulation Of Anatomical Structure Morphogenesis Heat Shock Protein Binding Unfolded Protein Binding Cellular Response To Oxygen-containing Compound Nucleotide Binding Plasma Membrane Enzyme-linked Receptor Protein Signaling Pathway Cell Migration Regulation Of Intrinsic Apoptotic Signaling Pathway G Protein-coupled Receptor Binding Positive Regulation Of Cell Migration ATP Hydrolysis Activity Developmental Process Positive Regulation Of Cell Motility Positive Regulation Of Multicellular Organismal Process Presynaptic Active Zone Positive Regulation Of Locomotion Regulation Of Cell Migration Ubiquitin Protein Ligase Binding Substantia Nigra Development Regulation Of Multicellular Organismal Development Response To Hormone Regulation Of Apoptotic Process	Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Growth Factor Activity Regulation Of Phosphorus Metabolic Process Protein Modification Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Protein Tag Activity Regulation Of Proteasomal Protein Catabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Protein Localization To Organelle Regulation Of Protein Metabolic Process Regulation Of Macromolecule Biosynthetic Process Receptor Tyrosine Kinase Binding Protein Modification By Small Protein Conjugation TORC1 Signaling Regulation Of Protein Catabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Protein-containing Complex Positive Regulation Of Gene Expression Regulation Of Purine Nucleotide Metabolic Process TOR Signaling Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Metabolic Process Intracellular Protein Localization Post-translational Protein Modification Regulation Of Cell Activation Regulation Of TORC1 Signaling Regulation Of Small Molecule Metabolic Process Positive Regulation Of Proteolysis Protein-folding Chaperone Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Component Organization Cellular Response To Oxygen-containing Compound Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process Cytokine Activity Regulation Of Protein Localization Positive Regulation Of Cell Population Proliferation Regulation Of Lymphocyte Activation Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Protein Metabolic Process Developmental Growth Protein Stabilization Positive Regulation Of Cell Activation Cellular Response To Manganese Ion
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