PTPRF and TRIO

Number of citations of the paper that reports this interaction (PubMedID 8643598)
42

Data Source:
HPRD (in vivo, in vitro)

		PTPRF	TRIO
Description		protein tyrosine phosphatase receptor type F	trio Rho guanine nucleotide exchange factor
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Neuron Projection Neuronal Cell Body Extracellular Exosome	Cytoplasm Cytosol Extrinsic Component Of Membrane Cell Projection Presynaptic Active Zone Postsynapse Glutamatergic Synapse
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Heparin Binding Hydrolase Activity Chondroitin Sulfate Proteoglycan Binding Protein-containing Complex Binding Cell Adhesion Molecule Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Cell Adhesion Signal Transduction Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Nervous System Development Regulation Of Neuron Projection Development Cell Migration Neuron Projection Regeneration Peptidyl-tyrosine Dephosphorylation Regulation Of Axon Regeneration Synaptic Membrane Adhesion Negative Regulation Of Receptor Binding	Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Axon Guidance Negative Regulation Of Fat Cell Differentiation Neuron Projection Morphogenesis Regulation Of Small GTPase Mediated Signal Transduction Postsynaptic Modulation Of Chemical Synaptic Transmission
Pathways		Receptor-type tyrosine-protein phosphatases Insulin receptor recycling Synaptic adhesion-like molecules	NRAGE signals death through JNK G alpha (q) signalling events G alpha (12/13) signalling events DCC mediated attractive signaling DCC mediated attractive signaling RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Attention deficit hyperactivity disorder ( 33495439 30478444) Attention deficit hyperactivity disorder or cannabis use ( 30610198) Autism spectrum disorder or schizophrenia ( 28540026) Coffee consumption ( 31046077) Cognitive ability (MTAG) ( 29186694) Disruptive behavior disorder and attention deficit hyperactivity disorder ( 33495439) Educational attainment ( 27046643) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Household income (MTAG) ( 31844048) Intake of total sugars ( 31005972) Intelligence (MTAG) ( 29326435) Mean reticulocyte volume ( 32888494) Refractive error ( 32231278) Schizophrenia ( 30285260 29483656 28991256 25056061) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Urate levels ( 31578528)	Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel) ( 24025145) Antidepressant treatment resistance (number of drugs prescribed) ( 30700811) Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Electroencephalogram traits ( 25387704) High density lipoprotein cholesterol levels ( 30498476) Intake of total sugars ( 31005972) Major depressive disorder ( 27777418) Paclitaxel-induced neuropathy ( 23776197) Physiological dysregulation (Mahalanobis distance) ( 32235003) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417) Waist circumference ( 28552196)
Interacting Genes		59 interacting genes: ACAN ACAT1 ACTB ARHGEF11 ARHGEF12 ARHGEF2 ATP5F1A BCAR1 CAV1 CBR1 CDH1 CREBBP CTNNB1 DEPDC1B DIAPH1 EEF1A1 EEF1G FRS2 FYN GALNT1 GAPDH GPC4 HSP90AA1 HSPA1A HSPA1L HSPA5 HSPA8 HSPA9 INSR IRS1 IRS2 JUP LACTB LCK LDHA LDHB NCAN NID1 OMG PPFIA1 PPFIA2 PPFIA3 PRPF40A PTPRA PTPRD PTPRZ1 RAP1GDS1 RET RHOA ROCK2 SEMG1 SEMG2 SEPTIN9 SKIL SOWAHC TRIO TUBA1B VCAN ZNF512B	13 interacting genes: BLMH CDC42 CDC5L DISC1 DSCR9 EXOC1 FLNA ITSN2 LIMS1 PTK2 PTPRF RAC1 RHOA
Entrez ID		5792	7204
HPRD ID		01552	03537
Ensembl ID		ENSG00000142949	ENSG00000038382
Uniprot IDs		G1UI20 P10586	O75962
PDB IDs		1LAR 2DJU 2DN7 2EDX 2EDY 2YD5 2YD8 4N5U 6KR4 6TPT 6TPU 6TPV 6TPW	1NTY 2NZ8 6D8Z 7SJ4
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Protein Refolding Phosphatidylinositol 3-kinase Binding ATP-dependent Protein Folding Chaperone Focal Adhesion Perineuronal Net Disordered Domain Specific Binding Protein Folding Chaperone Cell Adhesion Regulation Of Developmental Process Regulation Of Cellular Component Organization Regulation Of Protein Localization Cellular Response To Indole-3-methanol Tau Protein Binding Response To Indole-3-methanol Lysosomal Lumen Regulation Of Cell Motility Regulation Of Cell Communication Regulation Of Signaling Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Cell Motility Regulation Of Locomotion Cadherin Binding Regulation Of Signal Transduction Apical Junction Complex Regulation Of Intracellular Signal Transduction Regulation Of Cell Differentiation Regulation Of Anatomical Structure Morphogenesis Heat Shock Protein Binding Unfolded Protein Binding Cellular Response To Oxygen-containing Compound Nucleotide Binding Plasma Membrane Enzyme-linked Receptor Protein Signaling Pathway Cell Migration Regulation Of Intrinsic Apoptotic Signaling Pathway G Protein-coupled Receptor Binding Positive Regulation Of Cell Migration ATP Hydrolysis Activity Developmental Process Positive Regulation Of Cell Motility Positive Regulation Of Multicellular Organismal Process Presynaptic Active Zone Positive Regulation Of Locomotion Regulation Of Cell Migration Ubiquitin Protein Ligase Binding Substantia Nigra Development Regulation Of Multicellular Organismal Development Response To Hormone Regulation Of Apoptotic Process	Regulation Of Cell-substrate Adhesion Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Focal Adhesion Assembly Regulation Of Cell-substrate Junction Organization Focal Adhesion Cerebral Cortex Cell Migration Cell Motility Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Telencephalon Cell Migration Semaphorin-plexin Signaling Pathway Forebrain Cell Migration Membrane Invagination Positive Regulation Of Cell Migration Plasma Membrane Bounded Cell Projection Organization Regulation Of Neuron Migration Positive Regulation Of Stress Fiber Assembly Cell Migration Positive Regulation Of Cell Motility Establishment Or Maintenance Of Cell Polarity Non-canonical Wnt Signaling Pathway G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Locomotion Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Supramolecular Fiber Organization Cell Projection Assembly Cell-cell Junction Organization Cell Cortex Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Cytoskeleton Organization Thioesterase Binding G Protein Activity Cell Projection Organization Protein Kinase Binding Positive Regulation Of Integrin-mediated Signaling Pathway Postsynapse Positive Regulation Of Neuron Migration Establishment Of Cell Polarity Positive Regulation Of Growth Regulation Of Neural Precursor Cell Proliferation Regulation Of Stress Fiber Assembly Regulation Of Cell Junction Assembly Actin Filament Organization Regulation Of Actin Filament Organization Establishment Of Epithelial Cell Apical/basal Polarity
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