ARHGAP1 and SH3GL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARHGAP1	SH3GL1
Description		Rho GTPase activating protein 1	SH3 domain containing GRB2 like 1, endophilin A2
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Plasma Membrane Cilium Endosome Membrane Membrane Cell Leading Edge Perinuclear Region Of Cytoplasm Extracellular Exosome Sorting Endosome Plasma Membrane Bounded Cell Projection	Podosome Cytoplasm Endosome Cytosol Membrane Early Endosome Membrane Cell Projection Anchoring Junction Presynapse Glutamatergic Synapse
	Molecular Function	GTPase Activator Activity Protein Binding SH3 Domain Binding Small GTPase Binding Cadherin Binding	Protein Binding Lipid Binding Identical Protein Binding Cadherin Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Endosomal Transport Transferrin Transport Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Endocytic Recycling	Endocytosis Signal Transduction Central Nervous System Development
Pathways		RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle RND2 GTPase cycle	EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576) Bone mineral density (hip) ( 19801982) Experiencing mood swings ( 29500382) Fasting glucose ( 34059833) Feeling miserable ( 29500382) Feeling nervous ( 29500382) Femoral neck bone mineral density ( 22504420) Neurociticism ( 29500382) Reaction time ( 29844566) Schizophrenia ( 29483656) Suffering from nerves ( 29500382)	Appendicular lean mass ( 33097823) Hematocrit ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		26 interacting genes: ADGRB2 AGTRAP BNIP2 BNIPL CDC42 CHEK2 EPB41L1 HMGCR HSP90AB1 ITPR1 KIF1B LCOR LINC01554 MTNR1B OGT PIK3R1 PTPN11 RASA1 RHOA RHOC SH3GL1 SMARCD3 SRC TAX1BP1 TUBA4A WAS	35 interacting genes: ARHGAP1 ARHGAP8 AXIN1 B3GAT1 CCDC50 CMTM5 CREBBP DNM1 DNM1L DPPA4 DPYSL4 EEIG1 FBXO32 GPKOW ITCH ITSN2 MAL2 MTA1 NUTM2F PDCD6IP PML PRB3 PSMB1 PTPRO RHEX SCAMP5 SEPTIN8 SH2D4A SH3D19 SH3GL3 SOCS1 SPG21 SYNJ1 VPS37C YWHAZ
Entrez ID		392	6455
HPRD ID		04108	03462
Ensembl ID		ENSG00000175220	ENSG00000141985
Uniprot IDs		Q07960	Q6FGM0 Q99961
PDB IDs		1AM4 1GRN 1OW3 1RGP 1TX4 2NGR 5M6X 5M70 6R3V 7QSC 7QTM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Component Biogenesis Intracellular Signal Transduction Positive Regulation Of Cell Communication Protein Kinase Binding Regulation Of Stress Fiber Assembly Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Lamellipodium Organization Regulation Of Signal Transduction Skeletal Muscle Satellite Cell Migration Negative Regulation Of Cell-substrate Adhesion Regulation Of Actin Filament Organization Regulation Of Protein-containing Complex Assembly Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Signaling Regulation Of Protein Localization Regulation Of Cell Communication Regulation Of Signaling Regulation Of Actin Cytoskeleton Organization Regulation Of Cell-substrate Adhesion Positive Regulation Of Lamellipodium Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Lamellipodium Assembly Regulation Of Cellular Component Organization Signal Transduction Negative Regulation Of Cell-matrix Adhesion Apoptotic Process Regulation Of Cell Junction Assembly Actin Filament Organization Cell Junction Assembly Regulation Of Biological Quality Substrate Adhesion-dependent Cell Spreading Regulation Of Organelle Organization Regulation Of Cell-matrix Adhesion Negative Regulation Of Neutrophil Activation Phosphotyrosine Residue Binding Positive Regulation Of Lipase Activity Programmed Cell Death Apical Junction Assembly Cell Death Ephrin Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Blood Vessel Diameter Maintenance Regulation Of Synapse Organization Regulation Of Tube Size Positive Regulation Of Signal Transduction Supramolecular Fiber Organization	Negative Regulation Of Endocytic Recycling Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cytoplasm Membrane Fission
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