ARHGAP1 and BNIP2

Number of citations of the paper that reports this interaction (PMID 10954711)
10

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		ARHGAP1	BNIP2
Gene Name		Rho GTPase activating protein 1	BCL2/adenovirus E1B 19kDa interacting protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Cytosol Plasma Membrane Extracellular Vesicular Exosome	Nuclear Envelope Cytoplasm Cytosol Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	SH3/SH2 Adaptor Activity Rho GTPase Activator Activity Protein Binding SH3 Domain Binding Rac GTPase Activator Activity	GTPase Activator Activity Calcium Ion Binding Protein Binding Identical Protein Binding
	Biological Process	Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Rac GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Apoptotic Process Muscle Cell Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Positive Regulation Of Muscle Cell Differentiation
Pathways		Rho GTPase cycle Signaling by Rho GTPases	CDO in myogenesis Myogenesis
Drugs
Diseases
GWAS		Bone mineral density ( 22504420) Bone mineral density (hip) ( 19801982)
Protein-Protein Interactions		21 interactors: BAI2 BNIP2 BNIPL CDC42 CHEK2 EPB41L1 HMGCR HSP90AB1 ITPR1 KIF1B PIK3R1 PTPN11 RAC1 RASA1 RHOA RHOC SMARCD3 SRC TAX1BP1 TUBA4A WAS	13 interactors: ARHGAP1 ARHGAP8 BCL2 BNIPL CDC42 CREB3 FATE1 FGFR1 FRK KLC1 MYO5B NCBP1 UPK1B
Entrez ID		392	663
HPRD ID		04108	04481
Ensembl ID		ENSG00000175220	ENSG00000140299
Uniprot IDs		Q07960	J3KN59 Q12982
PDB IDs		1AM4 1GRN 1OW3 1RGP 1TX4 2NGR
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Wound Healing Blood Coagulation Fc Receptor Signaling Pathway Hemostasis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Response To Wounding Ephrin Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Body Fluid Levels Axon Guidance Phagocytosis Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway T Cell Costimulation Axonogenesis Movement Of Cell Or Subcellular Component Innate Immune Response Platelet Activation Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neurotrophin TRK Receptor Signaling Pathway Chemotaxis Neurotrophin Signaling Pathway Regulation Of Protein Transport Neuron Projection Morphogenesis Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Regulation Of Phosphatidylinositol 3-kinase Activity Programmed Cell Death Cell Morphogenesis Involved In Differentiation Cell Death Death Regulation Of Lipid Kinase Activity Regulation Of Protein Localization Cytoskeleton Organization Positive Regulation Of Intracellular Signal Transduction Neuron Projection Development Generation Of Neurons Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Projection Morphogenesis Developmental Process Cell Part Morphogenesis Regulation Of Immune Response Neurogenesis Locomotion	Regulation Of Protein Heterodimerization Activity Regulation Of Cell Proliferation Positive Regulation Of Catalytic Activity Gland Morphogenesis Regulation Of Intracellular Signal Transduction Epithelial Cell Differentiation Hair Follicle Morphogenesis Regulation Of Growth Epidermis Morphogenesis Salivary Gland Morphogenesis Positive Regulation Of Signal Transduction Salivary Gland Development Epidermis Development Skin Morphogenesis Neural Nucleus Development Cell Fate Commitment Exocrine System Development Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Muscle Tissue Development Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Negative Regulation Of Cellular PH Reduction Negative Regulation Of Ligand-dependent Nuclear Receptor Transcription Coactivator Activity CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Retinal Cell Programmed Cell Death Regulation Of Catalytic Activity Cellular Localization Positive Regulation Of Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Cellular Metabolic Process Midbrain Development Positive Regulation Of Muscle Cell Differentiation Adherens Junction Organization Regulation Of Cell Cycle Hair Follicle Development Stress Granule Disassembly Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Positive Regulation Of Hair Follicle Cell Proliferation Regulation Of Lateral Mesodermal Cell Fate Specification Release From Viral Latency Hair Cycle Process Renal System Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Intracellular Transport Regulation Of Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Peptidyl-serine Phosphorylation
Tagcloud ?		al7a1 c25h16orf71 conceptus ddx58 degs endometria ensbtat00000050193 estrus f2rl2 fbxl7 herc6 ifi16 ifnt insemination lims2 loc507810 mgc127874 mgc128929 parp12 rnaseq rnf213 samd9 serbp1 srgap2 tbc1d1 wbscr17 znfx1 zswim4 zxfx1	activator antiapoptotic attenuated bcl blocks cleavage cytotoxicity deacetylase imply inhibits intensified mediate mpp nad neuroprotective parp participates phenylpyridinium possibly resveratrol sh shrna sirna sirt1 sirtuin sy5y transfected transfection xl
Tagcloud (Difference) ?		al7a1 c25h16orf71 conceptus ddx58 degs endometria ensbtat00000050193 estrus f2rl2 fbxl7 herc6 ifi16 ifnt insemination lims2 loc507810 mgc127874 mgc128929 parp12 rnaseq rnf213 samd9 serbp1 srgap2 tbc1d1 wbscr17 znfx1 zswim4 zxfx1	activator antiapoptotic attenuated bcl blocks cleavage cytotoxicity deacetylase imply inhibits intensified mediate mpp nad neuroprotective parp participates phenylpyridinium possibly resveratrol sh shrna sirna sirt1 sirtuin sy5y transfected transfection xl
Tagcloud (Intersection) ?