ARHGAP1 and BNIP2

Number of citations of the paper that reports this interaction (PubMedID 10954711)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		ARHGAP1	BNIP2
Description		Rho GTPase activating protein 1	BCL2 interacting protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Plasma Membrane Cilium Endosome Membrane Membrane Cell Leading Edge Perinuclear Region Of Cytoplasm Extracellular Exosome Sorting Endosome Plasma Membrane Bounded Cell Projection	Nuclear Envelope Nucleolus Cytoplasm Centriole Cytosol Spindle Pole Centrosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activator Activity Protein Binding SH3 Domain Binding Small GTPase Binding Cadherin Binding	GTPase Activator Activity Calcium Ion Binding Protein Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Endosomal Transport Transferrin Transport Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Endocytic Recycling	Blastocyst Development Apoptotic Process Centrosome Cycle Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Differentiation Positive Regulation Of Small GTPase Mediated Signal Transduction Striated Muscle Cell Differentiation Response To Oxygen-glucose Deprivation
Pathways		RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle RND2 GTPase cycle	Myogenesis Myogenesis
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576) Bone mineral density (hip) ( 19801982) Experiencing mood swings ( 29500382) Fasting glucose ( 34059833) Feeling miserable ( 29500382) Feeling nervous ( 29500382) Femoral neck bone mineral density ( 22504420) Neurociticism ( 29500382) Reaction time ( 29844566) Schizophrenia ( 29483656) Suffering from nerves ( 29500382)	Gut microbiota (bacterial taxa) ( 27723756)
Interacting Genes		26 interacting genes: ADGRB2 AGTRAP BNIP2 BNIPL CDC42 CHEK2 EPB41L1 HMGCR HSP90AB1 ITPR1 KIF1B LCOR LINC01554 MTNR1B OGT PIK3R1 PTPN11 RASA1 RHOA RHOC SH3GL1 SMARCD3 SRC TAX1BP1 TUBA4A WAS	56 interacting genes: ABHD4 AGPAT3 APOBEC3B ARHGAP1 ARHGAP8 BCL2 BNIP3 BNIP5 BNIPL CDC42 CHODL CPLX4 CREB3 CYB5R3 DESI2 DGAT2L6 DHRS1 EI24 ERLIN1 FAHD1 FAM209A FAM3C FATE1 FGFR1 FRK GORAB GPR152 GPX8 GRAMD2A GSC2 HSPA1B KCNK5 KLC1 LDLRAD1 LIME1 LMNA MEOX1 MEOX2 MYO5B NCBP1 OTX2 PEX12 PLEKHO1 RASGRP4 SFT2D2 SIN3A SLC35E3 SLC39A9 SLC7A14 SYT1 SYT2 TMEM237 TMPRSS2 TMX2 UPK1B YIF1A
Entrez ID		392	663
HPRD ID		04108	04481
Ensembl ID		ENSG00000175220	ENSG00000140299
Uniprot IDs		Q07960	H7C096 Q12982
PDB IDs		1AM4 1GRN 1OW3 1RGP 1TX4 2NGR 5M6X 5M70 6R3V 7QSC 7QTM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Component Biogenesis Intracellular Signal Transduction Positive Regulation Of Cell Communication Protein Kinase Binding Regulation Of Stress Fiber Assembly Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Lamellipodium Organization Regulation Of Signal Transduction Skeletal Muscle Satellite Cell Migration Negative Regulation Of Cell-substrate Adhesion Regulation Of Actin Filament Organization Regulation Of Protein-containing Complex Assembly Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Signaling Regulation Of Protein Localization Regulation Of Cell Communication Regulation Of Signaling Regulation Of Actin Cytoskeleton Organization Regulation Of Cell-substrate Adhesion Positive Regulation Of Lamellipodium Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Lamellipodium Assembly Regulation Of Cellular Component Organization Signal Transduction Negative Regulation Of Cell-matrix Adhesion Apoptotic Process Regulation Of Cell Junction Assembly Actin Filament Organization Cell Junction Assembly Regulation Of Biological Quality Substrate Adhesion-dependent Cell Spreading Regulation Of Organelle Organization Regulation Of Cell-matrix Adhesion Negative Regulation Of Neutrophil Activation Phosphotyrosine Residue Binding Positive Regulation Of Lipase Activity Programmed Cell Death Apical Junction Assembly Cell Death Ephrin Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Blood Vessel Diameter Maintenance Regulation Of Synapse Organization Regulation Of Tube Size Positive Regulation Of Signal Transduction Supramolecular Fiber Organization	Protein Binding Endoplasmic Reticulum Membrane Regulation Of Growth Regulation Of Cell Growth Negative Regulation Of Endocytic Recycling Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Membrane Endoplasmic Reticulum Somite Specification Positive Regulation Of Growth Positive Regulation Of Cell Growth Regulation Of Vesicle Fusion Chromaffin Granule Membrane Mitochondrial Membrane
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?