ARHGAP1 and RHOC

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		ARHGAP1	RHOC
Description		Rho GTPase activating protein 1	ras homolog family member C
Image
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Plasma Membrane Cilium Endosome Membrane Membrane Cell Leading Edge Perinuclear Region Of Cytoplasm Extracellular Exosome Sorting Endosome Plasma Membrane Bounded Cell Projection	Nucleus Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Cleavage Furrow Stereocilium Extracellular Exosome
	Molecular Function	GTPase Activator Activity Protein Binding SH3 Domain Binding Small GTPase Binding Cadherin Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Endosomal Transport Transferrin Transport Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Endocytic Recycling	Mitotic Cytokinesis Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Protein-containing Complex Assembly Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Canonical NF-kappaB Signal Transduction Apical Junction Assembly Wound Healing, Spreading Of Cells Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Lipase Activity Skeletal Muscle Satellite Cell Migration
Pathways		RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle RND2 GTPase cycle	G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins RHOC GTPase cycle
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576) Bone mineral density (hip) ( 19801982) Experiencing mood swings ( 29500382) Fasting glucose ( 34059833) Feeling miserable ( 29500382) Feeling nervous ( 29500382) Femoral neck bone mineral density ( 22504420) Neurociticism ( 29500382) Reaction time ( 29844566) Schizophrenia ( 29483656) Suffering from nerves ( 29500382)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical surface area (visual PC2) ( 32198502) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate (creatinine) ( 28452372) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		26 interacting genes: ADGRB2 AGTRAP BNIP2 BNIPL CDC42 CHEK2 EPB41L1 HMGCR HSP90AB1 ITPR1 KIF1B LCOR LINC01554 MTNR1B OGT PIK3R1 PTPN11 RASA1 RHOA RHOC SH3GL1 SMARCD3 SRC TAX1BP1 TUBA4A WAS	8 interacting genes: ARHGAP1 CAV1 CIT DIAPH1 RIPOR2 RIPOR3 ROCK1 RTKN
Entrez ID		392	389
HPRD ID		04108	01322
Ensembl ID		ENSG00000175220	ENSG00000155366
Uniprot IDs		Q07960	A0A024R0C8 P08134
PDB IDs		1AM4 1GRN 1OW3 1RGP 1TX4 2NGR 5M6X 5M70 6R3V 7QSC 7QTM	1Z2C 2GCN 2GCO 2GCP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Component Biogenesis Intracellular Signal Transduction Positive Regulation Of Cell Communication Protein Kinase Binding Regulation Of Stress Fiber Assembly Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Lamellipodium Organization Regulation Of Signal Transduction Skeletal Muscle Satellite Cell Migration Negative Regulation Of Cell-substrate Adhesion Regulation Of Actin Filament Organization Regulation Of Protein-containing Complex Assembly Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Signaling Regulation Of Protein Localization Regulation Of Cell Communication Regulation Of Signaling Regulation Of Actin Cytoskeleton Organization Regulation Of Cell-substrate Adhesion Positive Regulation Of Lamellipodium Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Lamellipodium Assembly Regulation Of Cellular Component Organization Signal Transduction Negative Regulation Of Cell-matrix Adhesion Apoptotic Process Regulation Of Cell Junction Assembly Actin Filament Organization Cell Junction Assembly Regulation Of Biological Quality Substrate Adhesion-dependent Cell Spreading Regulation Of Organelle Organization Regulation Of Cell-matrix Adhesion Negative Regulation Of Neutrophil Activation Phosphotyrosine Residue Binding Positive Regulation Of Lipase Activity Programmed Cell Death Apical Junction Assembly Cell Death Ephrin Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Blood Vessel Diameter Maintenance Regulation Of Synapse Organization Regulation Of Tube Size Positive Regulation Of Signal Transduction Supramolecular Fiber Organization	Small GTPase Binding Rho Protein Signal Transduction Regulation Of Cytoskeleton Organization Mitotic Cytokinesis Cytoskeleton-dependent Cytokinesis Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Intracellular Signaling Cassette Negative Regulation Of Anoikis Actin Filament-based Process Regulation Of Anoikis Cell Death Apoptotic Process Programmed Cell Death Regulation Of Establishment Or Maintenance Of Cell Polarity Regulation Of Establishment Of Cell Polarity Membrane Raft Organization Cortical Actin Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Actin-mediated Cell Contraction Regulation Of Cell Projection Assembly Regulation Of Organelle Organization Cortical Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Microtubule-based Process Inward Rectifier Potassium Channel Inhibitor Activity Actin Filament-based Movement Negative Regulation Of Establishment Of T Cell Polarity Negative Regulation Of Protein Localization To Cell Leading Edge Response To Peptide Hormone Response To Transforming Growth Factor Beta System Process Regulation Of Actin Cytoskeleton Organization Protein Serine Kinase Activity Regulation Of Cellular Component Organization Regulation Of Developmental Process Caveolar Macromolecular Signaling Complex Positive Regulation Of Myeloid Dendritic Cell Activation Rho-dependent Protein Serine/threonine Kinase Activity Septin Ring Organization Negative Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity Regulation Of T Cell Activation Signaling Receptor Binding Protein Serine/threonine Kinase Activity Negative Regulation Of Endocytic Recycling Ruffle Positive Regulation Of Cell Junction Assembly Insulin Receptor Internalization Protein Localization To Basolateral Plasma Membrane
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?