ARHGAP1 and BNIPL

Number of citations of the paper that reports this interaction (PubMedID 12901880)
0

Data Source:
HPRD (in vitro, two hybrid)

		ARHGAP1	BNIPL
Description		Rho GTPase activating protein 1	BCL2 interacting protein like
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Plasma Membrane Cilium Endosome Membrane Membrane Cell Leading Edge Perinuclear Region Of Cytoplasm Extracellular Exosome Sorting Endosome Plasma Membrane Bounded Cell Projection	Nucleus Cytoplasm Cytosol
	Molecular Function	GTPase Activator Activity Protein Binding SH3 Domain Binding Small GTPase Binding Cadherin Binding	Protein Binding Identical Protein Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Endosomal Transport Transferrin Transport Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Endocytic Recycling	Apoptotic Process Negative Regulation Of Cell Population Proliferation Regulation Of Growth Rate
Pathways		RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle RND2 GTPase cycle
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576) Bone mineral density (hip) ( 19801982) Experiencing mood swings ( 29500382) Fasting glucose ( 34059833) Feeling miserable ( 29500382) Feeling nervous ( 29500382) Femoral neck bone mineral density ( 22504420) Neurociticism ( 29500382) Reaction time ( 29844566) Schizophrenia ( 29483656) Suffering from nerves ( 29500382)	Body mass index ( 26426971) Chronic kidney disease ( 20383146) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Type 2 diabetes ( 30297969)
Interacting Genes		26 interacting genes: ADGRB2 AGTRAP BNIP2 BNIPL CDC42 CHEK2 EPB41L1 HMGCR HSP90AB1 ITPR1 KIF1B LCOR LINC01554 MTNR1B OGT PIK3R1 PTPN11 RASA1 RHOA RHOC SH3GL1 SMARCD3 SRC TAX1BP1 TUBA4A WAS	13 interacting genes: ARHGAP1 BCL2 BCL2L1 BNIP2 FKBP8 GFER MIF NME2 PXDN PYCR1 RECQL5 RHOU SNAPIN
Entrez ID		392	149428
HPRD ID		04108	16557
Ensembl ID		ENSG00000175220	ENSG00000163141
Uniprot IDs		Q07960	Q7Z465
PDB IDs		1AM4 1GRN 1OW3 1RGP 1TX4 2NGR 5M6X 5M70 6R3V 7QSC 7QTM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Component Biogenesis Intracellular Signal Transduction Positive Regulation Of Cell Communication Protein Kinase Binding Regulation Of Stress Fiber Assembly Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Lamellipodium Organization Regulation Of Signal Transduction Skeletal Muscle Satellite Cell Migration Negative Regulation Of Cell-substrate Adhesion Regulation Of Actin Filament Organization Regulation Of Protein-containing Complex Assembly Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Signaling Regulation Of Protein Localization Regulation Of Cell Communication Regulation Of Signaling Regulation Of Actin Cytoskeleton Organization Regulation Of Cell-substrate Adhesion Positive Regulation Of Lamellipodium Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Lamellipodium Assembly Regulation Of Cellular Component Organization Signal Transduction Negative Regulation Of Cell-matrix Adhesion Apoptotic Process Regulation Of Cell Junction Assembly Actin Filament Organization Cell Junction Assembly Regulation Of Biological Quality Substrate Adhesion-dependent Cell Spreading Regulation Of Organelle Organization Regulation Of Cell-matrix Adhesion Negative Regulation Of Neutrophil Activation Phosphotyrosine Residue Binding Positive Regulation Of Lipase Activity Programmed Cell Death Apical Junction Assembly Cell Death Ephrin Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Blood Vessel Diameter Maintenance Regulation Of Synapse Organization Regulation Of Tube Size Positive Regulation Of Signal Transduction Supramolecular Fiber Organization	Dendritic Cell Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Intrinsic Apoptotic Signaling Pathway BH3 Domain Binding Negative Regulation Of Leukocyte Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of B Cell Apoptotic Process Protein Homotrimerization Regulation Of Signal Transduction Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Trimerization Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Anoikis Regulation Of B Cell Apoptotic Process Cytosol Negative Regulation Of Myeloid Cell Apoptotic Process Identical Protein Binding Programmed Cell Death Involved In Cell Development Release Of Cytochrome C From Mitochondria Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Apoptotic Signaling Pathway Isomerase Activity Regulation Of Anoikis Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Intracellular Signal Transduction Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Leukocyte Proliferation Sensory Organ Development Regulation Of Myeloid Cell Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Membrane Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Lymphocyte Apoptotic Process Cellular Response To Alkaloid Pigment Granule Organization Channel Activity Regulation Of Cellular Localization Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
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