PLAT and DDHD2

		PLAT	DDHD2
Description		plasminogen activator, tissue type	DDHD domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cell Surface Secretory Granule Extracellular Matrix Apical Part Of Cell Extracellular Exosome Serine Protease Inhibitor Complex Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Membrane COPII-coated ER To Golgi Transport Vesicle Centriolar Satellite
	Molecular Function	Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Phosphoprotein Binding	Phospholipase Activity Triacylglycerol Lipase Activity Hydrolase Activity Metal Ion Binding Diacylglycerol Lipase Activity
	Biological Process	Response To Hypoxia Proteolysis Blood Coagulation Negative Regulation Of Plasminogen Activation Smooth Muscle Cell Migration Zymogen Activation Plasminogen Activation Protein Modification Process Fibrinolysis Negative Regulation Of Proteolysis Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Fibrinolysis Prevention Of Polyspermy Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission	Mitochondrial Fission Lipid Metabolic Process Locomotory Behavior Visual Learning Lipid Catabolic Process Triglyceride Catabolic Process Lipid Droplet Organization Positive Regulation Of Mitochondrial Fission
Pathways		Signaling by PDGF Dissolution of Fibrin Clot	Synthesis of PA
Drugs		Aminocaproic acid Iloprost Human C1-esterase inhibitor 5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID Dexibuprofen Conestat alfa
Diseases
GWAS		Blood protein levels ( 30072576) Plasma plasminogen activator levels ( 24578379) Systemic lupus erythematosus ( 28714469)	Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 28991256 29483656)
Interacting Genes		28 interacting genes: ANXA2 APP CALR CKAP4 CLEC3B F10 FGA FN1 GRIN1 HMGB1 KRT8 LAMA1 LAMA3 LRP1 LRP1B MAPK1 MAPK3 MTDH PDGFC PLAU PLG SERPINA5 SERPINE1 SERPING1 SERPINI1 SNCA SPARC VDAC1	2 interacting genes: APP MTNR1A
Entrez ID		5327	23259
HPRD ID		01419	16788
Ensembl ID		ENSG00000104368	ENSG00000085788
Uniprot IDs		B4DN26 P00750	B3KPM6 O94830
PDB IDs		1A5H 1BDA 1PK2 1PML 1RTF 1TPG 1TPK 1TPM 1TPN 5BRR 5ZLZ
Enriched GO Terms of Interacting Partners?		Fibrinolysis Extracellular Space Regulation Of Locomotion Regulation Of Cell Migration Platelet Alpha Granule Lumen Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Motility Extracellular Region Positive Regulation Of Locomotion Endoplasmic Reticulum Lumen Negative Regulation Of Blood Coagulation Extracellular Matrix Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Wound Healing Serine-type Endopeptidase Inhibitor Activity Regulation Of Plasminogen Activation Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Platelet Alpha Granule Regulation Of Cell Adhesion Cell Surface Regulation Of Response To Wounding Regulation Of Multicellular Organismal Process Regulation Of Vesicle-mediated Transport Regulation Of Protein Maturation Positive Regulation Of Signaling Extracellular Exosome Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of Endocytosis Basement Membrane Plasma Membrane Negative Regulation Of Fibrinolysis Regulation Of Body Fluid Levels Positive Regulation Of Cell Communication Blood Coagulation Positive Regulation Of Cellular Component Organization Coagulation Protease Binding Hemostasis Peptidase Inhibitor Activity Regulation Of Endocytosis Negative Regulation Of Multicellular Organismal Process Calcium Ion Binding	Mating Behavior Reproductive Behavior Acetylcholine Receptor Activator Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Receptor Complex Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Melatonin Receptor Activity Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Prevention Of Polyspermy Trans-synaptic Signaling By BDNF Serine Protease Inhibitor Complex Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Trans-synaptic Signaling Axon Choice Point Recognition Synaptic Signaling Negative Regulation Of Plasminogen Activation Heparan Sulfate Binding Signaling Receptor Activator Activity Regulation Of Proteolysis Signaling Receptor Binding Peptidase Activator Activity
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