PLAT and SLC28A2

		PLAT	SLC28A2
Description		plasminogen activator, tissue type	solute carrier family 28 member 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cell Surface Secretory Granule Extracellular Matrix Apical Part Of Cell Extracellular Exosome Serine Protease Inhibitor Complex Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Plasma Membrane Vesicle Membrane Membrane Apicolateral Plasma Membrane Coated Vesicle Brush Border Membrane
	Molecular Function	Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Phosphoprotein Binding	Neurotransmitter Transmembrane Transporter Activity Nucleoside Transmembrane Transporter Activity Purine Nucleobase Transmembrane Transporter Activity Nucleoside:sodium Symporter Activity Purine Nucleoside Transmembrane Transporter Activity Uridine Transmembrane Transporter Activity Pyrimidine- And Adenosine-specific:sodium Symporter Activity Azole Transmembrane Transporter Activity
	Biological Process	Response To Hypoxia Proteolysis Blood Coagulation Negative Regulation Of Plasminogen Activation Smooth Muscle Cell Migration Zymogen Activation Plasminogen Activation Protein Modification Process Fibrinolysis Negative Regulation Of Proteolysis Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Fibrinolysis Prevention Of Polyspermy Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission	Retina Homeostasis Nucleobase-containing Compound Metabolic Process Xenobiotic Metabolic Process Neurotransmitter Transport Xenobiotic Transmembrane Transport Pyrimidine Nucleobase Transport Purine Nucleoside Transmembrane Transport Uridine Transmembrane Transport Adenosine Transport Inosine Transport Azole Transmembrane Transport Pyrimidine-containing Compound Transmembrane Transport Transport Across Blood-brain Barrier Nucleoside Transmembrane Transport Purine Nucleobase Transmembrane Transport
Pathways		Signaling by PDGF Dissolution of Fibrin Clot	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane Azathioprine ADME Ribavirin ADME
Drugs		Aminocaproic acid Iloprost Human C1-esterase inhibitor 5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID Dexibuprofen Conestat alfa
Diseases
GWAS		Blood protein levels ( 30072576) Plasma plasminogen activator levels ( 24578379) Systemic lupus erythematosus ( 28714469)	Estimated glomerular filtration rate ( 31015462) Uric acid levels ( 22229870) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		28 interacting genes: ANXA2 APP CALR CKAP4 CLEC3B F10 FGA FN1 GRIN1 HMGB1 KRT8 LAMA1 LAMA3 LRP1 LRP1B MAPK1 MAPK3 MTDH PDGFC PLAU PLG SERPINA5 SERPINE1 SERPING1 SERPINI1 SNCA SPARC VDAC1
Entrez ID		5327	9153
HPRD ID		01419	07069
Ensembl ID		ENSG00000104368	ENSG00000137860
Uniprot IDs		B4DN26 P00750	O43868 Q2M2A7 Q53H72
PDB IDs		1A5H 1BDA 1PK2 1PML 1RTF 1TPG 1TPK 1TPM 1TPN 5BRR 5ZLZ
Enriched GO Terms of Interacting Partners?		Fibrinolysis Extracellular Space Regulation Of Locomotion Regulation Of Cell Migration Platelet Alpha Granule Lumen Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Motility Extracellular Region Positive Regulation Of Locomotion Endoplasmic Reticulum Lumen Negative Regulation Of Blood Coagulation Extracellular Matrix Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Wound Healing Serine-type Endopeptidase Inhibitor Activity Regulation Of Plasminogen Activation Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Platelet Alpha Granule Regulation Of Cell Adhesion Cell Surface Regulation Of Response To Wounding Regulation Of Multicellular Organismal Process Regulation Of Vesicle-mediated Transport Regulation Of Protein Maturation Positive Regulation Of Signaling Extracellular Exosome Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of Endocytosis Basement Membrane Plasma Membrane Negative Regulation Of Fibrinolysis Regulation Of Body Fluid Levels Positive Regulation Of Cell Communication Blood Coagulation Positive Regulation Of Cellular Component Organization Coagulation Protease Binding Hemostasis Peptidase Inhibitor Activity Regulation Of Endocytosis Negative Regulation Of Multicellular Organismal Process Calcium Ion Binding	Negative Regulation Of Proteolysis Beta-endorphin Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose Protein-containing Complex Binding Bradykinin Catabolic Process Ubiquitin Recycling Cytosolic Proteasome Complex Insulin Catabolic Process Insulin Binding Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Prevention Of Polyspermy Trans-synaptic Signaling By BDNF Serine Protease Inhibitor Complex Regulation Of Body Fluid Levels Negative Regulation Of Plasminogen Activation Cellular Response To Thyroglobulin Triiodothyronine Response To Thyroglobulin Triiodothyronine Regulation Of Thyroid Hormone Receptor Signaling Pathway Male Mating Behavior Labyrinthine Layer Morphogenesis Carbon Catabolite Regulation Of Transcription Positive Regulation Of Female Receptivity Amyloid-beta Clearance By Cellular Catabolic Process Regulation Of Female Receptivity Female Mating Behavior Regulation Of Proteolysis Positive Regulation Of Protein Binding Peptidase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Plasminogen Activation Negative Regulation Of Fibrinolysis Trans-synaptic Signaling, Modulating Synaptic Transmission Regulation Of Fertilization Peroxisome Proliferator Activated Receptor Signaling Pathway Progesterone Receptor Signaling Pathway Estrous Cycle Smooth Muscle Cell Migration Positive Regulation Of Adipose Tissue Development Hormone Catabolic Process Hypothalamus Development Insulin Metabolic Process Peptide Catabolic Process Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Nuclear Retinoid X Receptor Binding Ovulation Cycle Nuclear Retinoic Acid Receptor Binding Regulation Of Biological Quality Negative Regulation Of Protein Metabolic Process Fibrinolysis
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