GPR152 and VKORC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GPR152	VKORC1
Description		G protein-coupled receptor 152	vitamin K epoxide reductase complex subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Identical Protein Binding	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Quinone Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway	Xenobiotic Metabolic Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Positive Regulation Of Coagulation Bone Development
Pathways			Metabolism of vitamin K
Drugs			Menadione Dicoumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases			Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS		Non-response to citalopram or escitalopram and depression ( 27622933) Refractive error ( 32231278)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Warfarin maintenance dose ( 18535201 19300499 20833655 26265036) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)
Interacting Genes		197 interacting genes: ABCG4 ABHD16A ACSF2 ADIPOQ AGTRAP AIG1 ANKRD46 APOL3 AQP10 AQP3 AQP6 ARL6IP1 ARV1 ATP6V0C B3GNT7 BDNF BET1 BMP10 BNIP2 BNIP3 C14orf180 C1QL4 C8A CCDC167 CCL4 CCL4L2 CD53 CD72 CD81 CDIPT CDS2 CGRRF1 CLDND2 CLEC17A CLEC1A CLN5 CNIH1 COL8A2 COMT CRISP3 CSGALNACT2 CTXN3 CYB561 CYB561A3 CYB5B CYB5R3 CYBC1 DEFB108B DGAT2L6 EBP EDDM3B EFNA5 EMD ERG28 ERGIC3 FA2H FAM209A FAM20B FAXDC2 FDFT1 FUNDC2 FXYD3 FXYD6-FXYD2 GAST GJB2 GOLT1A GOLT1B GOSR2 GPR151 GPR37L1 HHATL HMOX1 HMOX2 IFNA8 IGF2 IGFBP5 IL1RL1 INS-IGF2 INSIG2 JAGN1 KCNA1 KCNN4 LAMB1 LAT LEPROTL1 LHFPL2 LHFPL5 LTC4S MAL MAL2 MFF MFSD6 MGLL MGST3 MMD MOSPD3 MS4A13 MYADML2 NAT8 NDUFB11 NEU1 NINJ2 NIPAL4 ORMDL1 ORMDL3 PEDS1-UBE2V1 PEX16 PGAP2 PIGF PIN1 PLN PNLIPRP1 PRAF2 PROM2 PTPRN RABAC1 RBFA REEP6 ROBO2 RTN3 RTP2 SACM1L SCAMP4 SCD SEC22B SERF1A SERF1B SERP2 SFT2D2 SFTPC SLC10A1 SLC13A4 SLC29A2 SLC30A3 SLC35A4 SLC35B1 SLC35B4 SLC35F6 SLC35H1 SLC38A1 SLC38A7 SLC39A2 SLC41A1 SLC61A1 SLC66A1 SLC66A2 SLC7A1 SMCO4 STATH STX1B STX3 STX4 STX5 STX8 SYT15 SYT15B TAP1 TEX264 TFRC THBD THSD7B TIMMDC1 TM4SF19 TMEM100 TMEM120B TMEM128 TMEM140 TMEM14B TMEM14C TMEM201 TMEM208 TMEM218 TMEM236 TMEM237 TMEM243 TMEM254 TMEM42 TMEM50B TMEM54 TMEM60 TMEM97 TMPPE TNFRSF10C TSNARE1 TSPAN33 TSPAN7 TSPO2 UBIAD1 UNC50 VAMP1 VAMP4 VAMP5 VKORC1 YIPF1 YIPF4 YIPF6 ZDHHC15	93 interacting genes: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5MC3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CPLX4 CREB3 CREB3L1 CXADR DPM2 ECHDC1 FAM209A FAM210B FGG FGL1 FIS1 FTL GJB1 GORAB GPR152 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 LMNA MANBAL MSMO1 MSRB1 MT1X MUC1 PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMDN3 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC22A2 SLC25A1 SLC31A2 SLC7A14 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM35B TMEM45B TMT1B TRAM1 TREX1 VAPB YIF1A ZCCHC24
Entrez ID		390212	79001
HPRD ID		13599	10540
Ensembl ID		ENSG00000175514	ENSG00000167397
Uniprot IDs		A0A0I9RJ67 Q8TDT2	A0A0S2Z5X7 A0A0S2Z6I4 Q9BQB6
PDB IDs			6WV3 6WV4 6WV5 6WV6 6WV7 6WVH
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding SNAP Receptor Activity SNARE Complex Endomembrane System Golgi Membrane Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Sterol Biosynthetic Process SNARE Binding Vesicle-mediated Transport Membrane Organization Membrane Fusion Lipid Biosynthetic Process Pyrimidine Nucleotide-sugar Transmembrane Transport Nucleotide-sugar Transmembrane Transport Transmembrane Transport Cellular Localization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Organization Golgi Apparatus Cholesterol Biosynthetic Process Steroid Biosynthetic Process Membrane Docking Vesicle Docking Cortical Endoplasmic Reticulum Basolateral Plasma Membrane Lipid Metabolic Process Heme Oxidation Heme Oxygenase (decyclizing) Activity Lysine Transport Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Organelle Membrane Cholesterol Binding Nuclear Inner Membrane Organelle Localization By Membrane Tethering SNARE Complex Assembly Trans-Golgi Network Amyloid Fibril Formation Establishment Of Localization In Cell Establishment Of Protein Localization Nitric-oxide Synthase Complex UDP-glucose Transmembrane Transport Golgi Vesicle Transport Amino Acid Transmembrane Transport Water Channel Activity	Endoplasmic Reticulum Membrane Spherical High-density Lipoprotein Particle Very-low-density Lipoprotein Particle High-density Lipoprotein Particle High-density Lipoprotein Particle Receptor Binding Blood Microparticle Endoplasmic Reticulum Chylomicron Cholesterol Efflux Phospholipid Efflux Membrane Cholesterol Transport Phosphatidylcholine-sterol O-acyltransferase Activator Activity Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Sterol Transport Lipase Inhibitor Activity Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Plasma Lipoprotein Particle Clearance Extracellular Exosome Lipoprotein Metabolic Process Organic Hydroxy Compound Transport Asialoglycoprotein Receptor Activity Regulation Of Transport Endoplasmic Reticulum Lumen Regulation Of Intestinal Absorption Plasma Lipoprotein Particle Remodeling Response To Endoplasmic Reticulum Stress Cellular Response To Lipoprotein Particle Stimulus Protein-containing Complex Remodeling Lipid Transport Negative Regulation Of Lipid Transport Zymogen Activation Acute-phase Response Chemical Homeostasis Triglyceride Homeostasis Acylglycerol Homeostasis Peptidyl-methionine Modification Negative Regulation Of Cholesterol Import Myoblast Fusion Involved In Skeletal Muscle Regeneration Iron Ion Export Across Plasma Membrane Reverse Cholesterol Transport Regulation Of Lipid Transport Defense Response Endocytic Vesicle Lumen Cholesterol Binding Apolipoprotein Receptor Binding Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of Cholesterol Transport
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