GPR152 and TMEM218

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GPR152	TMEM218
Description		G protein-coupled receptor 152	transmembrane protein 218
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Cilium Membrane Cell Projection
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Non-response to citalopram or escitalopram and depression ( 27622933) Refractive error ( 32231278)	Breast cancer (survival) ( 25890600) Familial lung adenocarcinoma ( 29924316)
Interacting Genes		197 interacting genes: ABCG4 ABHD16A ACSF2 ADIPOQ AGTRAP AIG1 ANKRD46 APOL3 AQP10 AQP3 AQP6 ARL6IP1 ARV1 ATP6V0C B3GNT7 BDNF BET1 BMP10 BNIP2 BNIP3 C14orf180 C1QL4 C8A CCDC167 CCL4 CCL4L2 CD53 CD72 CD81 CDIPT CDS2 CGRRF1 CLDND2 CLEC17A CLEC1A CLN5 CNIH1 COL8A2 COMT CRISP3 CSGALNACT2 CTXN3 CYB561 CYB561A3 CYB5B CYB5R3 CYBC1 DEFB108B DGAT2L6 EBP EDDM3B EFNA5 EMD ERG28 ERGIC3 FA2H FAM209A FAM20B FAXDC2 FDFT1 FUNDC2 FXYD3 FXYD6-FXYD2 GAST GJB2 GOLT1A GOLT1B GOSR2 GPR151 GPR37L1 HHATL HMOX1 HMOX2 IFNA8 IGF2 IGFBP5 IL1RL1 INS-IGF2 INSIG2 JAGN1 KCNA1 KCNN4 LAMB1 LAT LEPROTL1 LHFPL2 LHFPL5 LTC4S MAL MAL2 MFF MFSD6 MGLL MGST3 MMD MOSPD3 MS4A13 MYADML2 NAT8 NDUFB11 NEU1 NINJ2 NIPAL4 ORMDL1 ORMDL3 PEDS1-UBE2V1 PEX16 PGAP2 PIGF PIN1 PLN PNLIPRP1 PRAF2 PROM2 PTPRN RABAC1 RBFA REEP6 ROBO2 RTN3 RTP2 SACM1L SCAMP4 SCD SEC22B SERF1A SERF1B SERP2 SFT2D2 SFTPC SLC10A1 SLC13A4 SLC29A2 SLC30A3 SLC35A4 SLC35B1 SLC35B4 SLC35F6 SLC35H1 SLC38A1 SLC38A7 SLC39A2 SLC41A1 SLC61A1 SLC66A1 SLC66A2 SLC7A1 SMCO4 STATH STX1B STX3 STX4 STX5 STX8 SYT15 SYT15B TAP1 TEX264 TFRC THBD THSD7B TIMMDC1 TM4SF19 TMEM100 TMEM120B TMEM128 TMEM140 TMEM14B TMEM14C TMEM201 TMEM208 TMEM218 TMEM236 TMEM237 TMEM243 TMEM254 TMEM42 TMEM50B TMEM54 TMEM60 TMEM97 TMPPE TNFRSF10C TSNARE1 TSPAN33 TSPAN7 TSPO2 UBIAD1 UNC50 VAMP1 VAMP4 VAMP5 VKORC1 YIPF1 YIPF4 YIPF6 ZDHHC15	75 interacting genes: APH1A AQP2 AQP6 ARL13B ASZ1 ATP6V0E1 BSCL2 CD300A CD53 CD79A CLDN2 CLEC10A CLEC17A CPLX4 CREB3L1 CTLA4 DAGLA EBP ELOVL2 ELOVL4 EMP1 ERGIC3 FAM209A FCER1G FFAR2 FRMD3 GDAP1 GJB1 GJB4 GJB6 GPR152 GPR61 GPX8 HSD17B13 IFNGR2 KCNJ6 KCNK5 KIR2DL3 LDLRAD1 LHFPL5 LMNA LSMEM2 MFF MS4A3 MTIF3 MUC1 NPFFR2 PCNA PDCD1LG2 PIK3IP1 PLEKHO1 PSCA RETREG3 SAR1A SDC3 SLC10A4 SLC10A6 SLC18A1 SMIM3 SSMEM1 TM4SF18 TMED8 TMEM106C TMEM182 TMEM207 TMEM234 TMEM31 TMEM45B TMEM52B TMEM88 TMPRSS2 TRHR TSPAN12 TSPAN18 VSIR
Entrez ID		390212	219854
HPRD ID		13599	19054
Ensembl ID		ENSG00000175514	ENSG00000150433
Uniprot IDs		A0A0I9RJ67 Q8TDT2	A2RU14 E9PI23
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding SNAP Receptor Activity SNARE Complex Endomembrane System Golgi Membrane Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Sterol Biosynthetic Process SNARE Binding Vesicle-mediated Transport Membrane Organization Membrane Fusion Lipid Biosynthetic Process Pyrimidine Nucleotide-sugar Transmembrane Transport Nucleotide-sugar Transmembrane Transport Transmembrane Transport Cellular Localization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Organization Golgi Apparatus Cholesterol Biosynthetic Process Steroid Biosynthetic Process Membrane Docking Vesicle Docking Cortical Endoplasmic Reticulum Basolateral Plasma Membrane Lipid Metabolic Process Heme Oxidation Heme Oxygenase (decyclizing) Activity Lysine Transport Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Organelle Membrane Cholesterol Binding Nuclear Inner Membrane Organelle Localization By Membrane Tethering SNARE Complex Assembly Trans-Golgi Network Amyloid Fibril Formation Establishment Of Localization In Cell Establishment Of Protein Localization Nitric-oxide Synthase Complex UDP-glucose Transmembrane Transport Golgi Vesicle Transport Amino Acid Transmembrane Transport Water Channel Activity	Membrane Plasma Membrane Protein Binding Connexin Complex Regulation Of Myoblast Fusion Gap Junction Channel Activity Gap Junction Bile Acid:sodium Symporter Activity Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Fucose Binding Gap Junction-mediated Intercellular Transport Renal Water Transport Gap Junction Assembly Fatty Acid Elongation, Saturated Fatty Acid
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