ASAP1 and DNAJB6

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		ASAP1	DNAJB6
Description		ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	DnaJ heat shock protein family (Hsp40) member B6
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GO Annotations	Cellular Component	Golgi Membrane Podosome Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Trans-Golgi Network Membrane Centriolar Satellite	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Z Disc Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding Cadherin Binding Metal Ion Binding	ATPase Activator Activity DNA Binding Protein Binding Hsp70 Protein Binding Heat Shock Protein Binding Identical Protein Binding Protein Folding Chaperone Unfolded Protein Binding Protein-folding Chaperone Binding
	Biological Process	Cell Projection Organization Cilium Assembly Protein Localization To Cilium Positive Regulation Of Membrane Tubulation	Protein Folding Actin Cytoskeleton Organization Extracellular Matrix Organization Regulation Of Protein Localization Protein Localization To Nucleus Intermediate Filament Organization Negative Regulation Of DNA-templated Transcription Nervous System Process Chorio-allantoic Fusion Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Chorion Development Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat
Pathways		VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium	Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Diisocyanate-induced asthma ( 25918132) HDL cholesterol levels in HIV infection ( 33109212) Mean corpuscular volume ( 32888494) Mean platelet volume ( 27863252 32888494) Multiple sclerosis ( 19525955) Nevus count or cutaneous melanoma ( 32341527) Platelet count ( 27863252) Platelet distribution width ( 32888494) Post bronchodilator FEV1 in COPD ( 26634245) Progressive supranuclear palsy ( 30089514) Refractive error ( 32231278) Sleep duration (> 10 hours) ( 33075057) Tuberculosis ( 25774636) Waist circumference adjusted for body mass index ( 28552196)	Body mass index ( 28552196) Retinal detachment or retinal break ( 31816047) Waist circumference ( 28552196)
Interacting Genes		15 interacting genes: ARF1 ARF6 CBL CRK DNAJB6 GRB2 HCK PACSIN3 PTK2 PTK2B PXN RAB11FIP3 REPS2 SH3KBP1 SRC	22 interacting genes: ANKRD1 APP ASAP1 BRMS1 CAND2 DYSF KRT18 MAP3K1 MLF1 MRTO4 MYBPC1 MYOM1 PGM1 PIK3CA POLR1D PTEN SGCG SKAP2 SUPT6H TTN TUBGCP3 USP8
Entrez ID		50807	10049
HPRD ID		05809	07107
Ensembl ID		ENSG00000153317	ENSG00000105993
Uniprot IDs		A0A0A0MRE5 Q9ULH1	A0A0J9YX62 E9PH18 O75190
PDB IDs		2D1X 2DA0 2ED1 2RQT 2RQU	6U3R 6U3S 7JSQ 7QBY
Enriched GO Terms of Interacting Partners?		Focal Adhesion Signal Complex Assembly Regulation Of Cellular Component Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization ERBB Signaling Pathway Regulation Of Actin Cytoskeleton Organization Ephrin Receptor Binding Regulation Of Actin Filament-based Process Enzyme-linked Receptor Protein Signaling Pathway Cytosol Regulation Of Cell Morphogenesis Endocytosis Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Actin Filament Organization Phosphotyrosine Residue Binding Positive Regulation Of Actin Filament Polymerization Vesicle-mediated Transport Plasma Membrane Positive Regulation Of Organelle Organization Regulation Of Cell Shape Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cellular Component Biogenesis Regulation Of Endocytosis Regulation Of Vesicle-mediated Transport Positive Regulation Of Supramolecular Fiber Organization Cell Cortex Import Into Cell Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Immune Effector Process Anchoring Junction Positive Regulation Of Protein Polymerization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Cytoplasm Positive Regulation Of Cellular Component Organization Integrin-mediated Signaling Pathway Protein Localization To Cleavage Furrow SH3 Domain Binding Cellular Response To Fluid Shear Stress Protein Autophosphorylation Fc-gamma Receptor Signaling Pathway Regulation Of Actin Filament Polymerization Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Tyrosine Kinase Activity	Sarcomere Organization Response To Mechanical Stimulus M Band Response To Muscle Stretch Actomyosin Structure Organization Positive Regulation Of Amyloid Fibril Formation Cytoskeleton Organization Structural Constituent Of Muscle Structural Molecule Activity Actin Cytoskeleton Organization Protein Kinase A Signaling Titin Binding Cytosol Actin Filament-based Process Regulation Of Amyloid Fibril Formation Positive Regulation Of Protein Localization Positive Regulation Of Protein Transport Myosin Filament Regulation Of Anoikis I Band Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Excitatory Postsynaptic Potential Intracellular Signaling Cassette Reproductive Behavior Organelle Organization Centriolar Satellite Positive Regulation Of Protein Secretion Regulation Of Protein Localization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Actin-mediated Cell Contraction Negative Regulation Of Synaptic Vesicle Clustering Monocyte Activation Involved In Immune Response Cytoplasm
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