ASAP1 and PACSIN3

Number of citations of the paper that reports this interaction (PMID 15719014)
33

Data Source:
HPRD (two hybrid)

		ASAP1	PACSIN3
Gene Name		ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	protein kinase C and casein kinase substrate in neurons 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Membrane	Nucleoplasm Cytoplasm Endosome Plasma Membrane Membrane Membrane-bounded Vesicle Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding ARF GTPase Activator Activity Zinc Ion Binding	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Lipid Binding Calcium Channel Inhibitor Activity
	Biological Process	Organelle Organization Regulation Of ARF GTPase Activity Positive Regulation Of GTPase Activity Cilium Morphogenesis	Endocytosis Cytoskeleton Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Calcium Ion Transport Membrane Tubulation
Pathways		Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance VxPx cargo-targeting to cilium Assembly of the primary cilium
Drugs
Diseases
GWAS		Multiple sclerosis ( 19525955)
Protein-Protein Interactions		13 interactors: ARF1 CBL CRK GRB2 HCK IKBKG PACSIN3 PTK2 PTK2B PXN REPS2 SH3KBP1 SRC	18 interactors: ADAM12 ADAM15 ASAP1 ASAP2 DNM1 ITSN1 LGALS13 PACSIN1 PACSIN2 PAK2 RAF1 SOS1 SOS2 SPRY2 SYNJ1 TERF2IP TRPV4 WASL
Entrez ID		50807	29763
HPRD ID		05809	05937
Ensembl ID		ENSG00000153317	ENSG00000165912
Uniprot IDs		Q9ULH1	Q9UKS6
PDB IDs		2D1X 2DA0 2ED1 2RQT 2RQU
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Complex Assembly Regulation Of Cellular Component Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cell Surface Receptor Signaling Pathway Regulation Of Cell Shape Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Endocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Endocytosis Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Response To Peptide Hormone Positive Regulation Of Protein Kinase Activity Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Positive Regulation Of Kinase Activity Response To Peptide Regulation Of Cytoskeleton Organization Signal Transduction Positive Regulation Of Immune System Process Regulation Of Organelle Organization Phagocytosis Vesicle-mediated Transport Peptidyl-tyrosine Phosphorylation Activation Of Protein Kinase Activity Response To Hormone Positive Regulation Of Transferase Activity Regulation Of Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus Signaling Response To Growth Factor Cell Communication Regulation Of MAPK Cascade	Cell Morphogenesis Cell Projection Morphogenesis Cell Part Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Anatomical Structure Morphogenesis Cell Projection Organization Enzyme Linked Receptor Protein Signaling Pathway Axon Guidance Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Development Regulation Of Ras Protein Signal Transduction Anatomical Structure Development Cell Differentiation Generation Of Neurons Regulation Of Small GTPase Mediated Signal Transduction Neuron Differentiation Neurogenesis Developmental Process Regulation Of Ras GTPase Activity Synaptic Vesicle Endocytosis Cell Development Synaptic Vesicle Recycling Establishment Of Organelle Localization Endocytosis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Endocytosis Organelle Localization Establishment Of Vesicle Localization Nervous System Development Regulation Of GTPase Activity Vesicle Localization Neurotrophin TRK Receptor Signaling Pathway Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Catalytic Activity Locomotion Regulation Of Signaling Neurotrophin Signaling Pathway Positive Regulation Of Signal Transduction Cell Communication Cell Surface Receptor Signaling Pathway
Tagcloud ?		actin apical associate bar basal base believed bleu cobl cordon curved ectopic localization localized microvillar microvilli nucleation nucleator pacsin participate proteomic recruit recruited sh3 shortens snx9 syndapin unlikely wh2
Tagcloud (Difference) ?		actin apical associate bar basal base believed bleu cobl cordon curved ectopic localization localized microvillar microvilli nucleation nucleator pacsin participate proteomic recruit recruited sh3 shortens snx9 syndapin unlikely wh2
Tagcloud (Intersection) ?