KCNQ1 and TRAF6

Number of citations of the paper that reports this interaction (PubMedID 14743216)
0

Data Source:
HPRD (in vitro)

		KCNQ1	TRAF6
Description		potassium voltage-gated channel subfamily Q member 1	TNF receptor associated factor 6
Image
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Early Endosome Late Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Endomembrane System Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Monoatomic Ion Channel Complex Potassium Channel Complex Neuron Projection Neuronal Cell Body Membrane Raft Apical Part Of Cell Basal Part Of Cell Ciliary Base Lumenal Side Of Membrane Basolateral Part Of Cell	Nucleus Cytoplasm Lipid Droplet Cytosol Plasma Membrane Cell Cortex Cytoplasmic Side Of Plasma Membrane Endosome Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Protein-containing Complex CD40 Receptor Complex Perinuclear Region Of Cytoplasm Glutamatergic Synapse
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Calmodulin Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein Phosphatase 1 Binding Outward Rectifier Potassium Channel Activity Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Transmembrane Transporter Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Atrial Cardiac Muscle Cell Action Potential Repolarization Scaffold Protein Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Protein-macromolecule Adaptor Activity Ubiquitin Conjugating Enzyme Binding Ubiquitin-ubiquitin Ligase Activity Signaling Adaptor Activity Identical Protein Binding Histone Deacetylase Binding Protein Kinase B Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Action Potential Gastric Acid Secretion Gastrin-induced Gastric Acid Secretion Regulation Of Heart Rate System Process Glucose Metabolic Process Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Heart Development Sensory Perception Of Sound Rhythmic Behavior Regulation Of Heart Contraction Regulation Of Blood Pressure Positive Regulation Of Heart Rate Iodide Transport Digestive System Process Erythrocyte Differentiation Intracellular Chloride Ion Homeostasis Response To Insulin Monoatomic Ion Transmembrane Transport Social Behavior Corticosterone Secretion Regulation Of Membrane Potential Inner Ear Morphogenesis Inner Ear Development Intestinal Absorption Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Regulation Of Transport Chloride Ion Homeostasis Potassium Ion Homeostasis Transmembrane Transport Cardiac Muscle Contraction Auditory Receptor Cell Development Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Cardiac Muscle Contraction Regulation Of Gastric Acid Secretion Cardiac Conduction Stomach Development Renal Absorption Renal Sodium Ion Absorption Cellular Response To CAMP Cellular Response To Xenobiotic Stimulus Potassium Ion Transmembrane Transport Cellular Response To Epinephrine Stimulus Adrenergic Receptor Signaling Pathway Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Cochlea Development Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Voltage-gated Potassium Channel Activity Non-motile Cilium Assembly Potassium Ion Import Across Plasma Membrane	Autophagosome Assembly Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Ossification In Utero Embryonic Development Neural Tube Closure Stimulatory C-type Lectin Receptor Signaling Pathway Immune System Process Regulation Of Immunoglobulin Production Positive Regulation Of T Cell Cytokine Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response DNA Damage Response Signal Transduction Canonical NF-kappaB Signal Transduction MRNA Transcription Animal Organ Morphogenesis Protein Ubiquitination Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II CD40 Signaling Pathway Osteoclast Differentiation Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Non-canonical NF-kappaB Signal Transduction Fc-epsilon Receptor Signaling Pathway Interleukin-33-mediated Signaling Pathway Interleukin-17A-mediated Signaling Pathway T-helper 1 Type Immune Response Positive Regulation Of T Cell Proliferation Odontogenesis Of Dentin-containing Tooth Defense Response To Bacterium Regulation Of Apoptotic Process Myeloid Dendritic Cell Differentiation Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of JUN Kinase Activity Innate Immune Response Bone Resorption Positive Regulation Of Osteoclast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Bone Remodeling Cell Development T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Interleukin-1-mediated Signaling Pathway Protein K63-linked Ubiquitination Response To Interleukin-1 Protein K48-linked Ubiquitination Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Interleukin-17-mediated Signaling Pathway Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Antiviral Innate Immune Response Intracellular Signaling Cassette Protein Branched Polyubiquitination Cellular Response To Oxygen-containing Compound Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways		Voltage gated Potassium channels Phase 3 - rapid repolarisation Phase 2 - plateau phase	PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Regulated proteolysis of p75NTR Downstream TCR signaling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 CLEC7A (Dectin-1) signaling Ub-specific processing proteases Ovarian tumor domain proteases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation MyD88 dependent cascade initiated on endosome IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Regulation of NF-kappa B signaling MyD88 cascade initiated on plasma membrane
Drugs		Enflurane Promethazine Miconazole Bepridil Dronedarone Azimilide ICA-105665 Isavuconazole
Diseases		Short QT syndrome Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS) Atrial fibrillation Type II diabetes mellitus
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 31043758) Blood pressure measurement (high sodium intervention) ( 24165912) Blood sugar levels ( 29403010) Body mass index ( 24861553 28892062 29381148) Childhood onset type 2 diabetes ( 33479058) Chronic kidney disease ( 29124443) Creatinine levels ( 29124443) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 20062063 25055868) Electrocardiographic traits (multivariate) ( 32602732) Estimated glomerular filtration rate ( 29124443 31451708 31152163 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Fasting glucose ( 34059833) Glomerular filtration rate (creatinine) ( 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Glucose homeostasis traits ( 25524916) Glycated hemoglobin levels ( 28898252 34059833) Gout ( 25967671) Height ( 25429064 20881960 28552196 31562340 25282103) Hemoglobin A1c levels ( 29403010) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hyperuricemia ( 29124443) Long QT syndrome ( 32429735) Malaria ( 31844061) Medication use (drugs used in diabetes) ( 31015401) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Mosquito bite size ( 28199695) Offspring birth weight ( 31043758) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) Platelet aggregation ( 20526338) Platelet count ( 32888494) Plateletcrit ( 32888494) Protein quantitative trait loci ( 18464913) QT interval ( 23166209 29213071 19305409 19305408 24952745 29874175 30679814) Serum uric acid levels ( 29124443) T wave morphology restitution during exercise (MTAG) ( 31607149) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) Two-hour glucose ( 34059833) Type 2 diabetes ( 24509480 18711366 18711367 19401414 20174558 20581827 21573907 21799836 22885922 22961080 23945395 32794382 24101674 32499647 24390345 30297969 25102180 26818947 26961502 28254843 28406950 31118516 28869590 30054458 30718926) Urate levels ( 31578528) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500 34021172) Waist-to-hip ratio adjusted for BMI ( 28552196)	Idiopathic inflammatory myopathy ( 26362759) Metabolite levels ( 23823483) Rheumatoid arthritis ( 24390342 30423114)
Interacting Genes		7 interacting genes: AKAP9 KCNE1 KCNE2 KCNE4 PPP1CA PRKACA TRAF6	184 interacting genes: ABL1 AKT1 APP ATM ATP6V1E1 ATXN3 BANK1 BCL3 BEX3 BMPR1B BRSK2 CAV1 CBL CD40 CUL5 CYLD DLG4 DNA2 ECSIT EDA2R EDARADD FADD FAM177A1 FHL2 FYN GART GTF2I H2AX H2BC21 HNRNPA1 HSD17B10 HSPA4 IL17RB IPMK IQUB IRAK1 IRAK2 IRAK3 IRAK4 IRF5 IRF7 IRF8 JAK2 KCNQ1 LIMD1 LNX1 MALT1 MAP2K1 MAP2K6 MAP2K7 MAP3K11 MAP3K14 MAP3K3 MAP3K5 MAP3K7 MAP3K8 MAPK14 MAPK8 MAPT MAST2 MATR3 MAVS MBP MCL1 MEOX2 MTOR MTURN NEAT1 NGFR NOL3 NTRK1 NTRK2 NUMBL OTUB1 OTUB2 OTUD7B PEDS1-UBE2V1 PELI3 PFN1 PHLDA1 PINK1 PLEKHF2 PLEKHO1 POLI PPP4C PRKCZ PSMB5 PSMC1 PSMC2 PSMC3 PSMD1 PSMD12 PSMD13 PSMD6 PSMD7 PTPN6 RAD23A RIPK1 RIPK2 RIPK3 RNF114 RNF152 RNF31 RPL3 RPS2 RPS20 RPS27A RSAD2 SIGIRR SPHK1 SPOP SQSTM1 SRC STAMBP STK17A STK26 STRADB STUB1 SUFU SYK TAB1 TAB2 TAB3 TANK TAX1BP1 TDP2 TGFBR1 TICAM1 TICAM2 TIFA TIRAP TLR3 TNFAIP3 TNFRSF11A TNFRSF13B TNFRSF19 TNFSF11 TRAF1 TRAF2 TRAF3IP1 TRAF3IP2 TRAF4 TRAF5 TRAF7 TRAFD1 TRAM1 TRIM17 TRIM25 TRIM37 TTC3 TXNIP UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2I UBE2L3 UBE2N UBE2V1 UBOX5 UBTD1 UBXN7 UEVLD USP1 USP15 USP2 USP21 USP39 USP7 VPS52 XIAP YBX1 YES1 YOD1 YWHAQ ZBTB25 ZDHHC11 ZFAND5 ZMYND11 ZNF675 ZRANB1
Entrez ID		3784	7189
HPRD ID		06341	03833
Ensembl ID		ENSG00000053918	ENSG00000175104
Uniprot IDs		P51787 Q96AI9	Q9Y4K3
PDB IDs		3BJ4 3HFC 3HFE 4UMO 4V0C 6MIE 6UZZ 6V00 6V01 7VUO 7VVD 7VVH 7XNI 7XNK 7XNL 7XNN 8SIK 8SIM 8SIN	1LB4 1LB5 1LB6 2ECI 2JMD 3HCS 3HCT 3HCU 4Z8M 5ZUJ 6A33 7L3L 8HZ2
Enriched GO Terms of Interacting Partners?		Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Heart Rate Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Potassium Channel Regulator Activity Cardiac Conduction Regulation Of Heart Contraction Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Ventricular Cardiac Muscle Cell Membrane Repolarization Potassium Ion Export Across Plasma Membrane Voltage-gated Potassium Channel Complex Ventricular Cardiac Muscle Cell Action Potential Regulation Of Blood Circulation Membrane Repolarization During Cardiac Muscle Cell Action Potential Delayed Rectifier Potassium Channel Activity Membrane Repolarization During Action Potential Membrane Repolarization Transmembrane Transporter Binding Cardiac Muscle Cell Action Potential Involved In Contraction Cardiac Muscle Cell Action Potential Regulation Of Biological Quality Voltage-gated Potassium Channel Activity Export Across Plasma Membrane Glutamatergic Synapse Regulation Of System Process Negative Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Voltage-gated Potassium Channel Activity Potassium Channel Activity Regulation Of Delayed Rectifier Potassium Channel Activity T-helper 1 Type Immune Response Action Potential Monoatomic Ion Channel Complex Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Membrane Potential Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Potassium Ion Transport Protein Kinase A Regulatory Subunit Binding Negative Regulation Of Transporter Activity Regulation Of Protein Localization To Synapse Regulation Of Cellular Localization Regulation Of Receptor Localization To Synapse Negative Regulation Of Potassium Ion Transport Regulation Of Multicellular Organismal Process Regulation Of Protein Targeting To Membrane Positive Regulation Of Glucose Metabolic Process Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport	Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Protein Modification Process Protein Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Post-translational Protein Modification Regulation Of Signaling Regulation Of Cell Communication Innate Immune Response-activating Signaling Pathway Positive Regulation Of Defense Response Pattern Recognition Receptor Signaling Pathway Activation Of Innate Immune Response Response To Stress Immune Response-regulating Signaling Pathway Regulation Of Defense Response Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Innate Immune Response Immune Response-activating Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Proteolysis Cytosol Activation Of Immune Response Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Polyubiquitination Positive Regulation Of Immune Response Regulation Of Innate Immune Response Macromolecule Metabolic Process Regulation Of Immune Response Defense Response Protein Kinase Activity MAPK Cascade Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Transferase Activity Negative Regulation Of Signal Transduction Regulation Of Cytokine-mediated Signaling Pathway Protein Ubiquitination Positive Regulation Of Protein Metabolic Process Positive Regulation Of Immune System Process Negative Regulation Of Signaling
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