KCNQ1 and KCNE2

Number of citations of the paper that reports this interaction (PMID 11101505)
54

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		KCNQ1	KCNE2
Gene Name		potassium channel, voltage gated KQT-like subfamily Q, member 1	potassium channel, voltage gated subfamily E regulatory beta subunit 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Early Endosome Late Endosome Plasma Membrane Voltage-gated Potassium Channel Complex Basolateral Plasma Membrane Cytoplasmic Vesicle Membrane	Lysosome Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Calmodulin Binding Protein Phosphatase 1 Binding Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Ion Channel Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Atrial Cardiac Muscle Cell Action Potential Repolarization Scaffold Protein Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	Inward Rectifier Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Regulator Activity Protein Homodimerization Activity Ion Channel Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Regulation Of Gene Expression By Genetic Imprinting Synaptic Transmission Sensory Perception Of Sound Regulation Of Heart Contraction Positive Regulation Of Heart Rate Gene Silencing Cellular Response To Drug Cardiac Muscle Contraction Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Cardiac Muscle Contraction Cellular Response To CAMP Potassium Ion Export Potassium Ion Transmembrane Transport Cellular Response To Epinephrine Stimulus Cardiovascular System Development Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Positive Regulation Of Potassium Ion Transmembrane Transport	Aging Potassium Ion Import Cellular Protein Localization Cellular Response To Drug Tongue Development Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Potassium Ion Export Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization Membrane Repolarization During Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Inward Rectifier Potassium Channel Activity Regulation Of Cyclic Nucleotide-gated Ion Channel Activity Regulation Of Delayed Rectifier Potassium Channel Activity
Pathways		Potassium Channels Voltage gated Potassium channels
Drugs		Indapamide Bepridil
Diseases
GWAS		Electrocardiographic traits ( 20062063) Height ( 20881960) Platelet aggregation ( 20526338) Protein quantitative trait loci ( 18464913) QT interval ( 23166209 19305408 19305409) Type 2 diabetes ( 21573907 18711366 18711367 21799836 22961080 20581827 19401414 20174558)	Body mass index (interaction) ( 23192594) Height ( 20881960) Myocardial infarction (early onset) ( 19198609) Pulmonary function ( 21946350)
Protein-Protein Interactions		7 interactors: AKAP9 KCNE1 KCNE2 KCNE4 PPP1CA PRKACA TRAF6	2 interactors: KCNH2 KCNQ1
Entrez ID		3784	9992
HPRD ID		06341	04813
Ensembl ID		ENSG00000053918
Uniprot IDs		P51787 Q96AI9	Q9Y6J6
PDB IDs		3BJ4 3HFC 3HFE
Enriched GO Terms of Interacting Partners?		Cardiac Conduction Regulation Of Heart Rate Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Regulation Of Ion Transmembrane Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Heart Contraction Regulation Of Potassium Ion Transmembrane Transport Regulation Of Ion Transport Regulation Of Potassium Ion Transport Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Striated Muscle Contraction Regulation Of Delayed Rectifier Potassium Channel Activity Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Potassium Ion Export Membrane Repolarization Regulation Of Muscle Contraction Positive Regulation Of Potassium Ion Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Regulation Of Lipopolysaccharide-mediated Signaling Pathway Triglyceride Catabolic Process Potassium Ion Transmembrane Transport Acylglycerol Catabolic Process Potassium Ion Transport Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Potassium Ion Transport Cardiac Muscle Cell Action Potential Regulation Of Membrane Potential Cellular Response To Organic Substance Regulation Of Cardiac Muscle Cell Contraction Cellular Response To CAMP Positive Regulation Of Myeloid Leukocyte Differentiation Epithelium Development Epithelial Tube Morphogenesis Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Organic Cyclic Compound Tube Morphogenesis Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Ion Transmembrane Transport Positive Regulation Of Protein Metabolic Process Response To Organic Substance Cellular Response To Organonitrogen Compound Response To Interleukin-1 Action Potential	Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Potassium Ion Export Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Membrane Repolarization Positive Regulation Of Potassium Ion Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Potassium Ion Transport Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Cardiac Muscle Contraction Cellular Response To Drug Regulation Of Potassium Ion Transport Heart Contraction Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Positive Regulation Of Ion Transmembrane Transport Striated Muscle Contraction Regulation Of Striated Muscle Contraction Action Potential Regulation Of Muscle Contraction Regulation Of Heart Contraction Potassium Ion Transmembrane Transport Positive Regulation Of Ion Transport Potassium Ion Transport Potassium Ion Export Across Plasma Membrane Negative Regulation Of Potassium Ion Export Muscle Contraction Muscle System Process Regulation Of Membrane Potential Regulation Of Heart Rate By Hormone Blood Circulation Regulation Of Actin Filament-based Process Regulation Of Ion Transmembrane Transport Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Response To Drug Positive Regulation Of Cardiac Muscle Contraction Synaptic Transmission Regulation Of Ion Transport Peptidyl-histidine Phosphorylation Regulation Of Heart Rate By Chemical Signal Atrial Cardiac Muscle Cell To AV Node Cell Communication Atrial Cardiac Muscle Cell Action Potential Monovalent Inorganic Cation Transport Regulation Of Cellular Component Movement
Tagcloud ?		amide arrhythmias backbone deafness foundation gated helical helices hypotheses inherited kcne kv7 kvlqt1 lay lyso micelles palmitoylphosphatidylglycerol s0 s1 s4 shares spans testable tetraspan topology voltage vsd vsds	aetiology bazett bqtc echocardiographic hodges hqtc https karyotypes kcnh2 lectaction lqts milliseconds nct00624949 prolongation prs qt qtc reader s0001fli scn5a selectprotocol settled sid thrice ts turner u000099e uid unexplained
Tagcloud (Difference) ?		amide arrhythmias backbone deafness foundation gated helical helices hypotheses inherited kcne kv7 kvlqt1 lay lyso micelles palmitoylphosphatidylglycerol s0 s1 s4 shares spans testable tetraspan topology voltage vsd vsds	aetiology bazett bqtc echocardiographic hodges hqtc https karyotypes kcnh2 lectaction lqts milliseconds nct00624949 prolongation prs qt qtc reader s0001fli scn5a selectprotocol settled sid thrice ts turner u000099e uid unexplained
Tagcloud (Intersection) ?