KCNQ1 and KCNE1

Number of citations of the paper that reports this interaction (PMID 11104781)
36

Data Source:
HPRD (in vitro)

		KCNQ1	KCNE1
Gene Name		potassium channel, voltage gated KQT-like subfamily Q, member 1	potassium channel, voltage gated subfamily E regulatory beta subunit 1
Image
Gene Ontology Annotations	Cellular Component	Lysosome Early Endosome Late Endosome Plasma Membrane Voltage-gated Potassium Channel Complex Basolateral Plasma Membrane Cytoplasmic Vesicle Membrane	Lysosome Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Z Disc
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Calmodulin Binding Protein Phosphatase 1 Binding Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Ion Channel Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Atrial Cardiac Muscle Cell Action Potential Repolarization Scaffold Protein Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Telethonin Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Regulation Of Gene Expression By Genetic Imprinting Synaptic Transmission Sensory Perception Of Sound Regulation Of Heart Contraction Positive Regulation Of Heart Rate Gene Silencing Cellular Response To Drug Cardiac Muscle Contraction Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Cardiac Muscle Contraction Cellular Response To CAMP Potassium Ion Export Potassium Ion Transmembrane Transport Cellular Response To Epinephrine Stimulus Cardiovascular System Development Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Positive Regulation Of Potassium Ion Transmembrane Transport	Protein N-linked Glycosylation Protein O-linked Glycosylation Sensory Perception Of Sound Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cellular Response To CAMP Potassium Ion Export Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Delayed Rectifier Potassium Channel Activity
Pathways		Potassium Channels Voltage gated Potassium channels
Drugs		Indapamide Bepridil	Indapamide
Diseases
GWAS		Electrocardiographic traits ( 20062063) Height ( 20881960) Platelet aggregation ( 20526338) Protein quantitative trait loci ( 18464913) QT interval ( 23166209 19305408 19305409) Type 2 diabetes ( 21573907 18711366 18711367 21799836 22961080 20581827 19401414 20174558)	Electrocardiographic traits ( 20062063)
Protein-Protein Interactions		7 interactors: AKAP9 KCNE1 KCNE2 KCNE4 PPP1CA PRKACA TRAF6	6 interactors: ADRB2 KCNH2 KCNQ1 PRKCA TPM3 UBASH3A
Entrez ID		3784	3753
HPRD ID		06341	01442
Ensembl ID		ENSG00000053918	ENSG00000180509
Uniprot IDs		P51787 Q96AI9	A7LFK2 A7LFK4 A8MWV9 C7S316 P15382 Q6FHJ6
PDB IDs		3BJ4 3HFC 3HFE	2K21
Enriched GO Terms of Interacting Partners?		Cardiac Conduction Regulation Of Heart Rate Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Regulation Of Ion Transmembrane Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Heart Contraction Regulation Of Potassium Ion Transmembrane Transport Regulation Of Ion Transport Regulation Of Potassium Ion Transport Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Striated Muscle Contraction Regulation Of Delayed Rectifier Potassium Channel Activity Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Potassium Ion Export Membrane Repolarization Regulation Of Muscle Contraction Positive Regulation Of Potassium Ion Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Regulation Of Lipopolysaccharide-mediated Signaling Pathway Triglyceride Catabolic Process Potassium Ion Transmembrane Transport Acylglycerol Catabolic Process Potassium Ion Transport Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Potassium Ion Transport Cardiac Muscle Cell Action Potential Regulation Of Membrane Potential Cellular Response To Organic Substance Regulation Of Cardiac Muscle Cell Contraction Cellular Response To CAMP Positive Regulation Of Myeloid Leukocyte Differentiation Epithelium Development Epithelial Tube Morphogenesis Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Organic Cyclic Compound Tube Morphogenesis Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Ion Transmembrane Transport Positive Regulation Of Protein Metabolic Process Response To Organic Substance Cellular Response To Organonitrogen Compound Response To Interleukin-1 Action Potential	Regulation Of Muscle Contraction Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Potassium Ion Export Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Membrane Repolarization Regulation Of Heart Contraction Positive Regulation Of Potassium Ion Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Muscle Contraction Cardiac Muscle Cell Action Potential Involved In Contraction Activation Of Adenylate Cyclase Activity Positive Regulation Of Potassium Ion Transport Muscle System Process Positive Regulation Of Adenylate Cyclase Activity Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Blood Circulation Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Positive Regulation Of Lyase Activity Cardiac Muscle Contraction Cellular Response To Drug Regulation Of Adenylate Cyclase Activity Regulation Of Potassium Ion Transport Positive Regulation Of CAMP Biosynthetic Process Heart Contraction Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Positive Regulation Of Ion Transmembrane Transport Striated Muscle Contraction Positive Regulation Of Cyclic Nucleotide Metabolic Process Action Potential Regulation Of Striated Muscle Contraction Regulation Of CAMP Biosynthetic Process Potassium Ion Export Across Plasma Membrane Negative Regulation Of Potassium Ion Export Positive Regulation Of Dense Core Granule Biogenesis Regulation Of CAMP Metabolic Process Synaptic Transmission Regulation Of Ion Transport Regulation Of Cellular Component Movement Regulation Of Heart Rate By Hormone Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Histone H3-T6 Phosphorylation Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure
Tagcloud ?		amide arrhythmias backbone deafness foundation gated helical helices hypotheses inherited kcne kv7 kvlqt1 lay lyso micelles palmitoylphosphatidylglycerol s0 s1 s4 shares spans testable tetraspan topology voltage vsd vsds	blockers channels coimmunoprecipitation contractions debate diversity electrophysiological exhibiting fail hek heteromers heterotetrameric heterotetramers kcne3 kv kv7 microdomains muscles myocytes oocyte photobleaching physiology raft shed smooth tune vasoconstriction vasorelaxants vessels
Tagcloud (Difference) ?		amide arrhythmias backbone deafness foundation gated helical helices hypotheses inherited kcne kvlqt1 lay lyso micelles palmitoylphosphatidylglycerol s0 s1 s4 shares spans testable tetraspan topology voltage vsd vsds	blockers channels coimmunoprecipitation contractions debate diversity electrophysiological exhibiting fail hek heteromers heterotetrameric heterotetramers kcne3 kv microdomains muscles myocytes oocyte photobleaching physiology raft shed smooth tune vasoconstriction vasorelaxants vessels
Tagcloud (Intersection) ?		kv7