KCNQ1 and PPP1CA

Number of citations of the paper that reports this interaction (PMID 11799244)
146

Data Source:
BioGRID (affinity chromatography technology, pull down)

		KCNQ1	PPP1CA
Gene Name		potassium channel, voltage gated KQT-like subfamily Q, member 1	protein phosphatase 1, catalytic subunit, alpha isozyme
Image
Gene Ontology Annotations	Cellular Component	Lysosome Early Endosome Late Endosome Plasma Membrane Voltage-gated Potassium Channel Complex Basolateral Plasma Membrane Cytoplasmic Vesicle Membrane	Protein Phosphatase Type 1 Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Glycogen Granule Dendritic Spine Perikaryon Extracellular Vesicular Exosome MLL5-L Complex PTW/PP1 Phosphatase Complex
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Calmodulin Binding Protein Phosphatase 1 Binding Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Ion Channel Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Atrial Cardiac Muscle Cell Action Potential Repolarization Scaffold Protein Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	Protein Serine/threonine Phosphatase Activity Protein Binding Phosphatase Activity Ribonucleoprotein Complex Binding Metal Ion Binding
	Biological Process	Regulation Of Gene Expression By Genetic Imprinting Synaptic Transmission Sensory Perception Of Sound Regulation Of Heart Contraction Positive Regulation Of Heart Rate Gene Silencing Cellular Response To Drug Cardiac Muscle Contraction Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Cardiac Muscle Contraction Cellular Response To CAMP Potassium Ion Export Potassium Ion Transmembrane Transport Cellular Response To Epinephrine Stimulus Cardiovascular System Development Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Positive Regulation Of Potassium Ion Transmembrane Transport	Glycogen Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Catabolic Process Protein Dephosphorylation Cell Cycle Transforming Growth Factor Beta Receptor Signaling Pathway Triglyceride Catabolic Process Lung Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Small Molecule Metabolic Process Branching Morphogenesis Of An Epithelial Tube Cell Division Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Potassium Channels Voltage gated Potassium channels	Loss of Function of TGFBR2 in Cancer Signaling by GPCR TGFBR2 MSI Frameshift Mutants in Cancer Metabolism of lipids and lipoproteins SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Opioid Signalling TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Lipid digestion, mobilization, and transport TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis DARPP-32 events SMAD4 MH2 Domain Mutants in Cancer
Drugs		Indapamide Bepridil
Diseases
GWAS		Electrocardiographic traits ( 20062063) Height ( 20881960) Platelet aggregation ( 20526338) Protein quantitative trait loci ( 18464913) QT interval ( 23166209 19305408 19305409) Type 2 diabetes ( 21573907 18711366 18711367 21799836 22961080 20581827 19401414 20174558)
Protein-Protein Interactions		7 interactors: AKAP9 KCNE1 KCNE2 KCNE4 PPP1CA PRKACA TRAF6	148 interactors: AATK AKAP1 AKAP11 AKAP9 AKT1 APAF1 AURKA BAD BAX BCL2 BCL2L1 BCL2L2 BRCA1 BTBD10 C1QA CAD CASC5 CAV1 CCDC181 CD2BP2 CDC5L CDH1 CEP170 CKB CLCN2 CLTC CNP CNST CNTN1 CREB1 CRK CSNK1E CSRNP1 CSRNP2 CUL1 CXXC1 DCTN1 DCX DEAF1 EED EIF2AK2 FRMPD4 FXYD1 GLIPR1L2 GLTSCR2 GPKOW H2AFX HEYL HSPA4 IBTK ID2 JPH3 KANK1 KCNQ1 KCTD20 KIAA1377 KIF13A KIF18A LMTK2 LPIN2 MAFG MAL2 MAP4K4 MAPK1 MAPK3 MIIP MPHOSPH10 MST1R MYO16 NCAM1 NDP NEK2 NOC2L NOM1 NONO PCDH7 PCNA PHACTR1 PHACTR3 PHACTR4 PHC1 PIAS1 PIAS3 PLCL2 POLR2A PPP1R10 PPP1R11 PPP1R13B PPP1R13L PPP1R15A PPP1R15B PPP1R16A PPP1R18 PPP1R1B PPP1R2 PPP1R26 PPP1R2P3 PPP1R2P9 PPP1R32 PPP1R37 PPP1R3B PPP1R3C PPP1R3D PPP1R3E PPP1R3G PPP1R8 PPP1R9A PPP1R9B PPP2CA PREX1 PRKCB PRKCD PRR16 PTEN RANBP9 RB1 RIF1 RPRD2 SFPQ SFRP1 SH3RF2 SKP1 SLC45A1 SNCAIP SORL1 SPRED1 STAM STAU1 SYTL2 TCTEX1D4 TOE1 TOR1AIP1 TOX4 TP53 TP53BP2 TPRN TUSC3 UBE2Z ULK1 VDR WBP11 WDR82 WWTR1 YLPM1 ZBTB11 ZFYVE16 ZFYVE9 ZNF827
Entrez ID		3784	5499
HPRD ID		06341	15942
Ensembl ID		ENSG00000053918	ENSG00000172531
Uniprot IDs		P51787 Q96AI9	P62136
PDB IDs		3BJ4 3HFC 3HFE	3E7A 3E7B 3EGG 3EGH 3HVQ 3N5U 3V4Y 4G9J
Enriched GO Terms of Interacting Partners?		Cardiac Conduction Regulation Of Heart Rate Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Regulation Of Ion Transmembrane Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Heart Contraction Regulation Of Potassium Ion Transmembrane Transport Regulation Of Ion Transport Regulation Of Potassium Ion Transport Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Striated Muscle Contraction Regulation Of Delayed Rectifier Potassium Channel Activity Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Potassium Ion Export Membrane Repolarization Regulation Of Muscle Contraction Positive Regulation Of Potassium Ion Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Regulation Of Lipopolysaccharide-mediated Signaling Pathway Triglyceride Catabolic Process Potassium Ion Transmembrane Transport Acylglycerol Catabolic Process Potassium Ion Transport Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Potassium Ion Transport Cardiac Muscle Cell Action Potential Regulation Of Membrane Potential Cellular Response To Organic Substance Regulation Of Cardiac Muscle Cell Contraction Cellular Response To CAMP Positive Regulation Of Myeloid Leukocyte Differentiation Epithelium Development Epithelial Tube Morphogenesis Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Organic Cyclic Compound Tube Morphogenesis Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Ion Transmembrane Transport Positive Regulation Of Protein Metabolic Process Response To Organic Substance Cellular Response To Organonitrogen Compound Response To Interleukin-1 Action Potential	Regulation Of Catalytic Activity Regulation Of Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Regulation Of Phosphatase Activity Regulation Of Dephosphorylation Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Phosphatase Activity Apoptotic Process Negative Regulation Of Dephosphorylation Regulation Of Cellular Component Organization Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Process Positive Regulation Of Cellular Protein Metabolic Process Cell Death Negative Regulation Of Cellular Metabolic Process Death Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Cell Cycle Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Cell Cycle Process Regulation Of Phosphorylation Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Amino Acid Metabolic Process Organelle Organization Intracellular Signal Transduction Regulation Of Protein Phosphorylation Mitotic Cell Cycle Process Regulation Of Organelle Organization Cellular Response To Stress Mitotic Cell Cycle Positive Regulation Of Protein Modification Process Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Differentiation Cellular Response To Organic Substance Response To Organic Substance Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Protein Kinase Activity Developmental Process Positive Regulation Of Catalytic Activity Multicellular Organismal Development Anatomical Structure Development Negative Regulation Of Kinase Activity
Tagcloud ?		amide arrhythmias backbone deafness foundation gated helical helices hypotheses inherited kcne kv7 kvlqt1 lay lyso micelles palmitoylphosphatidylglycerol s0 s1 s4 shares spans testable tetraspan topology voltage vsd vsds	0x 1x adamts13 aspm atp6v0a2 bioinformatic bl chickens col12a1 fowl grm5 interpretations jungle lrp2 obscn plau prkdc resequencing rnf168 sanger sl slv smyth stab2 ubc ubiquitinylation vitiliginous vitiligo xirp1
Tagcloud (Difference) ?		amide arrhythmias backbone deafness foundation gated helical helices hypotheses inherited kcne kv7 kvlqt1 lay lyso micelles palmitoylphosphatidylglycerol s0 s1 s4 shares spans testable tetraspan topology voltage vsd vsds	0x 1x adamts13 aspm atp6v0a2 bioinformatic bl chickens col12a1 fowl grm5 interpretations jungle lrp2 obscn plau prkdc resequencing rnf168 sanger sl slv smyth stab2 ubc ubiquitinylation vitiliginous vitiligo xirp1
Tagcloud (Intersection) ?