KCNQ1 and KCNE4

Number of citations of the paper that reports this interaction (PMID 12670483)
4

Data Source:
HPRD (in vivo)

		KCNQ1	KCNE4
Gene Name		potassium channel, voltage gated KQT-like subfamily Q, member 1	potassium channel, voltage gated subfamily E regulatory beta subunit 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Early Endosome Late Endosome Plasma Membrane Voltage-gated Potassium Channel Complex Basolateral Plasma Membrane Cytoplasmic Vesicle Membrane	Integral Component Of Membrane Apical Plasma Membrane
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Calmodulin Binding Protein Phosphatase 1 Binding Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Ion Channel Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Atrial Cardiac Muscle Cell Action Potential Repolarization Scaffold Protein Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	Voltage-gated Potassium Channel Activity
	Biological Process	Regulation Of Gene Expression By Genetic Imprinting Synaptic Transmission Sensory Perception Of Sound Regulation Of Heart Contraction Positive Regulation Of Heart Rate Gene Silencing Cellular Response To Drug Cardiac Muscle Contraction Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Cardiac Muscle Contraction Cellular Response To CAMP Potassium Ion Export Potassium Ion Transmembrane Transport Cellular Response To Epinephrine Stimulus Cardiovascular System Development Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Positive Regulation Of Potassium Ion Transmembrane Transport	Regulation Of Ion Transmembrane Transport Potassium Ion Transmembrane Transport
Pathways		Potassium Channels Voltage gated Potassium channels
Drugs		Indapamide Bepridil
Diseases
GWAS		Electrocardiographic traits ( 20062063) Height ( 20881960) Platelet aggregation ( 20526338) Protein quantitative trait loci ( 18464913) QT interval ( 23166209 19305408 19305409) Type 2 diabetes ( 21573907 18711366 18711367 21799836 22961080 20581827 19401414 20174558)	Acute lymphoblastic leukemia (childhood) ( 19684603) Body mass index ( 20966902) Waist circumference ( 20966902)
Protein-Protein Interactions		7 interactors: AKAP9 KCNE1 KCNE2 KCNE4 PPP1CA PRKACA TRAF6	6 interactors: FLNA KCNA1 KCNQ1 OBSL1 PRKCA TSNAX
Entrez ID		3784	23704
HPRD ID		06341	09689
Ensembl ID		ENSG00000053918	ENSG00000152049
Uniprot IDs		P51787 Q96AI9	A5H1P5 B7Z275
PDB IDs		3BJ4 3HFC 3HFE
Enriched GO Terms of Interacting Partners?		Cardiac Conduction Regulation Of Heart Rate Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Regulation Of Ion Transmembrane Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Heart Contraction Regulation Of Potassium Ion Transmembrane Transport Regulation Of Ion Transport Regulation Of Potassium Ion Transport Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Striated Muscle Contraction Regulation Of Delayed Rectifier Potassium Channel Activity Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Potassium Ion Export Membrane Repolarization Regulation Of Muscle Contraction Positive Regulation Of Potassium Ion Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Regulation Of Lipopolysaccharide-mediated Signaling Pathway Triglyceride Catabolic Process Potassium Ion Transmembrane Transport Acylglycerol Catabolic Process Potassium Ion Transport Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Potassium Ion Transport Cardiac Muscle Cell Action Potential Regulation Of Membrane Potential Cellular Response To Organic Substance Regulation Of Cardiac Muscle Cell Contraction Cellular Response To CAMP Positive Regulation Of Myeloid Leukocyte Differentiation Epithelium Development Epithelial Tube Morphogenesis Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Organic Cyclic Compound Tube Morphogenesis Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Ion Transmembrane Transport Positive Regulation Of Protein Metabolic Process Response To Organic Substance Cellular Response To Organonitrogen Compound Response To Interleukin-1 Action Potential	Regulation Of Muscle Contraction Action Potential Potassium Ion Export Across Plasma Membrane Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Positive Regulation Of Dense Core Granule Biogenesis Synaptic Transmission Histone H3-T6 Phosphorylation Cellular Component Assembly Regulation Of Heart Contraction Detection Of Abiotic Stimulus Sensory Perception Of Mechanical Stimulus Potassium Ion Transmembrane Transport Cardiovascular System Development Cellular Response To Magnesium Ion Neuronal Signal Transduction Platelet Activation Cell-cell Signaling Cell Junction Assembly Potassium Ion Transport Sensory Perception Of Touch Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Anatomical Structure Formation Involved In Morphogenesis Multicellular Organismal Development Positive Regulation Of Cardiac Muscle Contraction Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Membrane Potential Desmosome Assembly Atrial Cardiac Muscle Cell Action Potential Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Atrial Cardiac Muscle Cell To AV Node Cell Communication Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Positive Regulation Of Striated Muscle Contraction Potassium Ion Export Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation MRNA Transcription From RNA Polymerase II Promoter Desmosome Organization Developmental Process Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cell Communication By Electrical Coupling MRNA Transcription Negative Regulation Of Transport Cell-cell Signaling Involved In Cardiac Conduction Magnesium Ion Homeostasis Negative Regulation Of Glucose Transport Cellular Response To Epinephrine Stimulus
Tagcloud ?		amide arrhythmias backbone deafness foundation gated helical helices hypotheses inherited kcne kv7 kvlqt1 lay lyso micelles palmitoylphosphatidylglycerol s0 s1 s4 shares spans testable tetraspan topology voltage vsd vsds	akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668
Tagcloud (Difference) ?		amide arrhythmias backbone deafness foundation gated helical helices hypotheses inherited kcne kv7 kvlqt1 lay lyso micelles palmitoylphosphatidylglycerol s0 s1 s4 shares spans testable tetraspan topology voltage vsd vsds	akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668
Tagcloud (Intersection) ?