DTNA and SNTB1

Number of citations of the paper that reports this interaction (PubMedID 10545507)
60

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vitro, in vivo)

		DTNA	SNTB1
Description		dystrobrevin alpha	syntrophin beta 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Membrane Cell Junction Axon Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Protein-containing Complex Sarcolemma Cell Projection Intermediate Filament Cytoskeleton Synapse	Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Dystrophin-associated Glycoprotein Complex Membrane Protein-containing Complex Sarcolemma Synapse Anchoring Junction
	Molecular Function	Protein Binding Zinc Ion Binding PDZ Domain Binding Metal Ion Binding	Actin Binding Structural Molecule Activity Protein Binding Calmodulin Binding PDZ Domain Binding
	Biological Process	Striated Muscle Contraction Signal Transduction Chemical Synaptic Transmission Neuromuscular Synaptic Transmission Synaptic Signaling	Muscle Contraction
Pathways		Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs
Diseases
GWAS		Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) PR interval ( 32439900) Urate levels in overweight individuals ( 25811787)	Apolipoprotein A1 levels ( 32203549) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Cerebrospinal T-tau levels ( 28247064) Eye morphology ( 29921221) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 33339817 29083408) JT interval (sulfonylurea treatment interaction) ( 27958378) Myopia (pathological) ( 23406873) Myopia (severe) ( 23933737) Periodontitis (CDC/AAP) ( 24024966) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Thalamus volume ( 31530798)
Interacting Genes		16 interacting genes: ACTA1 APPL1 DMD DRP2 DTNBP1 GFI1B KCNJ12 SNTA1 SNTB1 SNTB2 SNTG1 SNTG2 STAT3 SYNC SYNM UTRN	15 interacting genes: ABCA1 ACVR2B ADGRB1 ADRA1D DGKZ DMD DTNA ERBB4 KCNJ12 MAPK12 RPS6KA1 SCN4A SCN5A UTRN VANGL2
Entrez ID		1837	6641
HPRD ID		03141	02490
Ensembl ID		ENSG00000134769	ENSG00000172164
Uniprot IDs		A0A7P0T9L1 A0A7P0TBH9 A0A7P0Z4D7 B7Z3X3 Q9Y4J8	Q13884
PDB IDs		2E5R	7P70 7PC4
Enriched GO Terms of Interacting Partners?		Dystrophin-associated Glycoprotein Complex Sarcolemma Syntrophin Complex Muscle Contraction Muscle System Process Actin Binding Vinculin Binding Structural Molecule Activity Cytoskeleton Regulation Of Sodium Ion Transmembrane Transport System Process Regulation Of Sodium Ion Transport Protein-containing Complex Filopodium Nitric-oxide Synthase Binding Neuromuscular Junction PDZ Domain Binding Plasma Membrane Costamere Structural Constituent Of Cytoskeleton Regulation Of Monoatomic Ion Transmembrane Transport Synapse Filopodium Membrane Myosin Binding Regulation Of Transport Positive Regulation Of Endocytosis Anchoring Junction Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Monoatomic Ion Transport Cardiac Muscle Cell Action Potential Structural Constituent Of Muscle Calmodulin Binding Regulation Of Heart Contraction Fast-twitch Skeletal Muscle Fiber Contraction Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cytoplasm Postsynaptic Membrane Regulation Of Blood Circulation Lateral Plasma Membrane Regulation Of Monoatomic Cation Transmembrane Transport Postsynaptic Density Glutamatergic Synapse Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Neurofilament Cytoskeleton Positive Regulation Of Macropinocytosis Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Actin Cytoskeleton Signaling Striated Muscle Contraction Cell Communication	Muscle Contraction Muscle System Process Plasma Membrane Sarcolemma Muscle Organ Development Muscle Structure Development Regulation Of Sodium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Cell Communication Regulation Of Multicellular Organismal Process Lateral Plasma Membrane Regulation Of Sodium Ion Transport Vinculin Binding Striated Muscle Contraction Nitric-oxide Synthase Binding Voltage-gated Sodium Channel Complex Regulation Of Blood Circulation Regulation Of System Process Dystrophin-associated Glycoprotein Complex Regulation Of Striated Muscle Contraction Signal Transduction Cell-cell Signaling System Process Regulation Of Monoatomic Ion Transmembrane Transport Action Potential Regulation Of Skeletal Muscle Contraction Filopodium Membrane Voltage-gated Sodium Channel Activity Kinase Activity Signaling Establishment Of Planar Polarity Monoatomic Ion Channel Complex Synaptic Signaling Membrane Protein Serine/threonine/tyrosine Kinase Activity Phagocytosis, Engulfment Regulation Of Monoatomic Ion Transport Regulation Of Developmental Process Monoatomic Cation Channel Activity Regulation Of Muscle Contraction Sodium Channel Activity Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Developmental Process Regulation Of Biological Quality Regulation Of Heart Contraction Cardiac Muscle Contraction T-tubule ATP Binding Membrane Invagination Sphingolipid Floppase Activity
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