DTNA and KCNJ12

Number of citations of the paper that reports this interaction (PMID 15024025)
29

Data Source:
HPRD (in vivo, in vitro)

		DTNA	KCNJ12
Gene Name		dystrobrevin, alpha	potassium channel, inwardly rectifying subfamily J, member 12
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cell Junction Axon Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Sarcolemma Protein Complex Synapse	Plasma Membrane Integral Component Of Plasma Membrane Intrinsic Component Of Membrane
	Molecular Function	Protein Binding Zinc Ion Binding PDZ Domain Binding	Inward Rectifier Potassium Channel Activity
	Biological Process	Striated Muscle Contraction Signal Transduction Synaptic Transmission Neuromuscular Synaptic Transmission	Potassium Ion Transport Muscle Contraction Synaptic Transmission Regulation Of Heart Contraction Potassium Ion Import Regulation Of Ion Transmembrane Transport Protein Homotetramerization
Pathways			GABA B receptor activation Inwardly rectifying K+ channels GABA receptor activation Activation of G protein gated Potassium channels Classical Kir channels Activation of GABAB receptors Potassium Channels Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Transmission across Chemical Synapses
Drugs			Dofetilide
Diseases
GWAS			Height ( 20881960)
Protein-Protein Interactions		14 interactors: ACTA1 DMD DRP2 DTNBP1 GFI1B KCNJ12 SNTA1 SNTB1 SNTB2 SNTG1 SNTG2 SYNC SYNM UTRN	16 interactors: ABLIM1 APBA1 CASK DLG1 DLG2 DLG3 DLG4 DMD DTNA LIN7A LIN7B LIN7C PRKACA SNTA1 SNTB1 SNTB2
Entrez ID		1837	3768
HPRD ID		03141	09083
Ensembl ID		ENSG00000134769	ENSG00000184185
Uniprot IDs		A8K541 B7Z3X3 M0QYX6 Q9Y4J8	Q14500
PDB IDs		2E5R
Enriched GO Terms of Interacting Partners?		Muscle Contraction Muscle System Process Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Sodium Ion Transmembrane Transport Regulation Of Sodium Ion Transport Regulation Of Ion Transport Regulation Of Ion Transmembrane Transport Regulation Of Heart Contraction Regulation Of Sodium Ion Transmembrane Transporter Activity Myotube Cell Development Actin-myosin Filament Sliding Muscle Filament Sliding Cardiac Muscle Cell Action Potential Intermediate Filament-based Process Actin-mediated Cell Contraction Muscle Fiber Development Positive Regulation Of Cell-matrix Adhesion Muscle Organ Development Myotube Differentiation Actin Filament-based Movement Regulation Of Vasoconstriction By Circulating Norepinephrine Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Action Potential Regulation Of Striated Muscle Contraction Skeletal Muscle Fiber Adaptation Establishment Of Glial Blood-brain Barrier Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Muscle Structure Development Skeletal Muscle Tissue Development Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Establishment Of Blood-nerve Barrier Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Skeletal Muscle Organ Development System Development Regulation Of Muscle Contraction Striated Muscle Cell Development Synaptic Transmission Regulation Of Dopamine Receptor Signaling Pathway Skeletal Muscle Thin Filament Assembly Olfactory Nerve Development Muscle Cell Development Regulation Of Skeletal Muscle Contraction Actin Filament-based Process Skeletal Myofibril Assembly Neurotransmitter Receptor Metabolic Process Regulation Of Cell-substrate Adhesion Platelet Dense Granule Organization	Establishment Or Maintenance Of Apical/basal Cell Polarity Cell-cell Signaling Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Maintenance Of Apical/basal Cell Polarity Receptor Localization To Synapse Synaptic Transmission Maintenance Of Cell Polarity Nucleotide Phosphorylation Protein Localization To Synapse Establishment Or Maintenance Of Cell Polarity Protein Localization To Membrane Protein Localization To Basolateral Plasma Membrane Maintenance Of Epithelial Cell Apical/basal Polarity Membrane Organization Cellular Protein Localization Receptor Clustering Regulation Of Ion Transmembrane Transport Muscle Contraction Muscle System Process Protein Localization Asymmetric Protein Localization Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Ion Transport Regulation Of Sodium Ion Transmembrane Transport Secretion Protein Localization To Plasma Membrane Cellular Localization Endomembrane System Organization Regulation Of Sodium Ion Transport Plasma Membrane Organization Secretion By Cell Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Movement Of Cell Or Subcellular Component Anatomical Structure Development Nucleotide Metabolic Process Regulation Of Membrane Potential Regulation Of Striated Muscle Contraction Chemotaxis Nervous System Development System Development Nucleobase-containing Small Molecule Metabolic Process Neurotransmitter Secretion Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Exocytosis Developmental Process Signaling Cellular Component Assembly Cell Communication Axon Guidance
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