KCNJ1 and EI24

Data Source: HiPPIP (Novel)

		KCNJ1	EI24
Name		potassium inwardly rectifying channel subfamily J member 1	EI24 autophagy associated transmembrane protein
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Monoatomic Ion Channel Complex	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Nuclear Membrane
	Molecular Function	Nucleotide Binding Inward Rectifier Potassium Channel Activity Potassium Channel Activity ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding ATP-activated Inward Rectifier Potassium Channel Activity	Protein Binding Importin-alpha Family Protein Binding
	Biological Process	Kidney Development Tissue Homeostasis Monoatomic Ion Transport Potassium Ion Transport Post-embryonic Development Gene Expression Metal Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Renal Sodium Ion Absorption Circulatory System Development Potassium Ion Import Across Plasma Membrane	Autophagy Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Xenobiotic Stimulus Macroautophagy Negative Regulation Of Cell Growth Negative Regulation Of Protein Import Into Nucleus Neuromuscular Process Controlling Balance Cellular Response To UV-C Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Potassium transport channels	None
Drugs		Bethanidine Glimepiride Minoxidil Acetohexamide Ritodrine Tolbutamide Glymidine Yohimbine Agmatine Butamben	None
Diseases		Bartter syndrome	None
GWAS		No GWAS studies recorded	Alanine aminotransferase levels ( 33547301 ) Body mass index ( 28552196 )
Novel Interactors		4 novel interactors: APLP2 CTSV EI24 NID2	2 novel interactors: KCNJ1 NRGN
Interacting Genes		6 interacting genes: GOLGA3 NHERF1 NHERF2 PRKCD SGK1 SH3RF1	6 interacting genes: BNIP2 CCR8 PGRMC2 RABAC1 TMED8 TMEM14B
Entrez ID		3758	9538
HPRD ID		08981	05526
Ensembl ID		ENSG00000151704	ENSG00000149547
Uniprot IDs		A8K432 P48048	E9PK61 O14681
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Chloride Channel Regulator Activity Regulation Of Apoptotic Signaling Pathway Response To Aldosterone Positive Regulation Of Apoptotic Signaling Pathway Renal Sodium Ion Transport Protein-membrane Adaptor Activity Response To Mineralocorticoid Positive Regulation Of Transporter Activity Renal Absorption Endomembrane System Phosphatase Binding Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Regulation Of Protein Import Into Nucleus Renal Phosphate Ion Absorption Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Cellular Response To UV Positive Regulation Of Sphingomyelin Catabolic Process Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Cellular Response To Light Stimulus Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Phospholipid Catabolic Process Positive Regulation Of Endodeoxyribonuclease Activity Termination Of Signal Transduction Beta-catenin Binding Negative Regulation Of Filopodium Assembly Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Deoxyribonuclease Activity Protein Kinase C Signaling Renal System Process Extracellular Exosome Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of Catalytic Activity Negative Regulation Of MAPK Cascade Positive Regulation Of Programmed Cell Death Response To UV Regulation Of Intracellular Protein Transport Positive Regulation Of Ceramide Biosynthetic Process Regulation Of Protein Localization To Nucleus Regulation Of Endodeoxyribonuclease Activity Regulation Of Intracellular Signal Transduction Regulation Of Phospholipid Catabolic Process Cellular Response To Aldosterone	None