KCNJ1 and NID2

Data Source: HiPPIP (Novel)

		KCNJ1	NID2
Name		potassium inwardly rectifying channel subfamily J member 1	nidogen 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Monoatomic Ion Channel Complex	Extracellular Region Basement Membrane Extracellular Space Plasma Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	Nucleotide Binding Inward Rectifier Potassium Channel Activity Potassium Channel Activity ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding ATP-activated Inward Rectifier Potassium Channel Activity	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding
	Biological Process	Kidney Development Tissue Homeostasis Monoatomic Ion Transport Potassium Ion Transport Post-embryonic Development Gene Expression Metal Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Renal Sodium Ion Absorption Circulatory System Development Potassium Ion Import Across Plasma Membrane	Cell Adhesion Cell-matrix Adhesion Basement Membrane Organization
Pathways		Potassium transport channels	Laminin interactions Laminin interactions
Drugs		Bethanidine Glimepiride Minoxidil Acetohexamide Ritodrine Tolbutamide Glymidine Yohimbine Agmatine Butamben	None
Diseases		Bartter syndrome	None
GWAS		No GWAS studies recorded	Age-related hearing impairment ( 34108613 ) Apolipoprotein A1 levels ( 32203549 ) Body mass index ( 28892062 ) Craniofacial microsomia ( 26853712 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) HDL cholesterol levels ( 32203549 ) Hip index ( 34021172 ) Lung cancer (smoking interaction) ( 24658283 ) Pulmonary function ( 17903307 ) Triglyceride levels ( 32203549 29403010 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Waist-to-hip ratio adjusted for body mass index ( 26785701 ) White matter hyperintensity volume ( 33293549 ) White matter hyperintensity volume (adjusted for hypertension) ( 33293549 ) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549 )
Novel Interactors		4 novel interactors: APLP2 CTSV EI24 NID2	3 novel interactors: KCNJ1 POLE2 TNFRSF14
Interacting Genes		6 interacting genes: GOLGA3 NHERF1 NHERF2 PRKCD SGK1 SH3RF1	24 interacting genes: ANKRD13D CCN3 COL13A1 COL1A1 COL4A1 ELN GNE HOXC8 HSPG2 KPRP KRTAP1-3 KRTAP10-3 KRTAP6-2 LAMC1 LCE1A MAML3 PITX1 PLSCR4 RBP3 SKIL TFG UNKL ZNF581 ZNF774
Entrez ID		3758	22795
HPRD ID		08981	05654
Ensembl ID		ENSG00000151704	ENSG00000087303
Uniprot IDs		A8K432 P48048	Q14112
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Chloride Channel Regulator Activity Regulation Of Apoptotic Signaling Pathway Response To Aldosterone Positive Regulation Of Apoptotic Signaling Pathway Renal Sodium Ion Transport Protein-membrane Adaptor Activity Response To Mineralocorticoid Positive Regulation Of Transporter Activity Renal Absorption Endomembrane System Phosphatase Binding Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Regulation Of Protein Import Into Nucleus Renal Phosphate Ion Absorption Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Cellular Response To UV Positive Regulation Of Sphingomyelin Catabolic Process Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Cellular Response To Light Stimulus Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Phospholipid Catabolic Process Positive Regulation Of Endodeoxyribonuclease Activity Termination Of Signal Transduction Beta-catenin Binding Negative Regulation Of Filopodium Assembly Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Deoxyribonuclease Activity Protein Kinase C Signaling Renal System Process Extracellular Exosome Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of Catalytic Activity Negative Regulation Of MAPK Cascade Positive Regulation Of Programmed Cell Death Response To UV Regulation Of Intracellular Protein Transport Positive Regulation Of Ceramide Biosynthetic Process Regulation Of Protein Localization To Nucleus Regulation Of Endodeoxyribonuclease Activity Regulation Of Intracellular Signal Transduction Regulation Of Phospholipid Catabolic Process Cellular Response To Aldosterone	Extracellular Matrix Basement Membrane Extracellular Matrix Structural Constituent Conferring Tensile Strength Extracellular Matrix Structural Constituent Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Tissue Development Platelet-derived Growth Factor Binding Extracellular Matrix Constituent Conferring Elasticity Skeletal Muscle Tissue Development Collagen Trimer Collagen-activated Signaling Pathway Extracellular Matrix Organization Extracellular Structure Organization Circulatory System Development