KCNF1 and TSPO

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KCNF1	TSPO
Description		potassium voltage-gated channel modifier subfamily F member 1	translocator protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex Ciliary Base	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Mitochondrial Membrane Extracellular Exosome
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity	Androgen Binding Protein Binding Benzodiazepine Receptor Activity Cholesterol Binding Transmembrane Transporter Binding Cholesterol Transfer Activity
	Biological Process	Action Potential Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Transport Protein Homooligomerization Transmembrane Transport Potassium Ion Transmembrane Transport Non-motile Cilium Assembly	Protein Targeting To Mitochondrion Steroid Biosynthetic Process C21-steroid Hormone Biosynthetic Process Heme Biosynthetic Process Monoatomic Ion Transport Monoatomic Anion Transport Chloride Transport Lipid Transport Steroid Metabolic Process Glial Cell Migration Response To Xenobiotic Stimulus Response To Manganese Ion Response To Vitamin B1 Peripheral Nervous System Axon Regeneration Sterol Transport Adrenal Gland Development Negative Regulation Of Protein Ubiquitination Regulation Of Cholesterol Transport Response To Progesterone Negative Regulation Of Tumor Necrosis Factor Production Response To Testosterone Regulation Of Cell Population Proliferation Cholesterol Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Response To Pain Behavioral Response To Pain Response To Axon Injury Regulation Of Steroid Biosynthetic Process Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of Calcium Ion Transport Contact Inhibition Positive Regulation Of Glial Cell Proliferation Negative Regulation Of Glial Cell Proliferation Positive Regulation Of Programmed Necrotic Cell Death Cellular Response To Lipopolysaccharide Cellular Response To Zinc Ion Cellular Hypotonic Response Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Negative Regulation Of Mitophagy Negative Regulation Of ATP Metabolic Process Response To Acetylcholine Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Corticosterone Secretion
Pathways		Voltage gated Potassium channels	Pregnenolone biosynthesis
Drugs		Enflurane Promethazine Miconazole	Chlormezanone Zopiclone
Diseases
GWAS			Metabolite levels ( 23823483) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) White blood cell count ( 32888494)
Interacting Genes		13 interacting genes: ALOX15B CLPTM1L FARS2 KCNG3 KCNG4 KCNH1 KCNV2 MCL1 OPRM1 SERP1 SLC39A7 TCEA2 TSPO	17 interacting genes: AMIGO1 CLEC10A CREB3L1 DBI FAM209A FCER1G ICAM3 KCNF1 LEUTX LHFPL5 LYPD5 MEOX2 NCR3LG1 PVR TMEM14B TMEM9 TSPOAP1
Entrez ID		3754	706
HPRD ID		04808	15913
Ensembl ID		ENSG00000162975	ENSG00000100300
Uniprot IDs		Q9H3M0	O76068 P30536
PDB IDs
Enriched GO Terms of Interacting Partners?		Voltage-gated Potassium Channel Activity Potassium Channel Activity Voltage-gated Potassium Channel Complex Monoatomic Ion Transport Monoatomic Ion Channel Complex Monoatomic Cation Transmembrane Transport Metal Ion Transport Inorganic Cation Transmembrane Transport Potassium Ion Transmembrane Transport Inorganic Ion Transmembrane Transport Monoatomic Ion Channel Activity Transmembrane Transport Potassium Ion Transport Potassium Channel Regulator Activity Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Nitric Oxide Biosynthetic Process Action Potential Regulation Of Biological Quality Protein Homooligomerization Endocannabinoid Signaling Pathway Negative Regulation Of Corticosterone Secretion Cyclic Nucleotide Binding Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Protein Complex Oligomerization Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Regulation Of Potassium Ion Transmembrane Transport Membrane Linoleate 9S-lipoxygenase Activity Linoleate 13S-lipoxygenase Activity Arachidonate 15-lipoxygenase Activity Arachidonate 8(S)-lipoxygenase Activity Lipoxin A4 Biosynthetic Process Cannabinoid Biosynthetic Process Lipoxin Biosynthetic Process Lipoxin A4 Metabolic Process Cannabinoid Signaling Pathway Contact Inhibition Response To Vitamin B1 Regulation Of Metal Ion Transport BH Domain Binding Cellular Response To Morphine Phenylalanine-tRNA Ligase Activity Phenylalanyl-tRNA Aminoacylation Regulation Of Potassium Ion Transport Negative Regulation Of Glucocorticoid Secretion	Benzodiazepine Receptor Binding
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