KCNF1 and ALOX15B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KCNF1	ALOX15B
Description		potassium voltage-gated channel modifier subfamily F member 1	arachidonate 15-lipoxygenase type B
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex Ciliary Base	Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Membrane Extracellular Exosome Anchoring Junction
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity	Iron Ion Binding Calcium Ion Binding Protein Binding Lipid Binding Linoleate 13S-lipoxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Arachidonate 8(S)-lipoxygenase Activity Metal Ion Binding Arachidonate 15-lipoxygenase Activity Dioxygenase Activity Linoleate 9S-lipoxygenase Activity
	Biological Process	Action Potential Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Transport Protein Homooligomerization Transmembrane Transport Potassium Ion Transmembrane Transport Non-motile Cilium Assembly	Lipid Metabolic Process Phospholipid Metabolic Process Apoptotic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Arachidonate Metabolic Process Lipoxygenase Pathway Negative Regulation Of Cell Migration Prostate Gland Development Regulation Of Epithelial Cell Differentiation Positive Regulation Of Chemokine Production Lipid Oxidation Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Linoleic Acid Metabolic Process Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Cell Cycle Negative Regulation Of Growth Hepoxilin Biosynthetic Process Endocannabinoid Signaling Pathway Cannabinoid Biosynthetic Process Lipoxin A4 Biosynthetic Process
Pathways		Voltage gated Potassium channels	Synthesis of 15-eicosatetraenoic acid derivatives
Drugs		Enflurane Promethazine Miconazole
Diseases
GWAS			Blood protein levels ( 30072576) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483)
Interacting Genes		13 interacting genes: ALOX15B CLPTM1L FARS2 KCNG3 KCNG4 KCNH1 KCNV2 MCL1 OPRM1 SERP1 SLC39A7 TCEA2 TSPO	9 interacting genes: CTAG1A CTAG1B KCNF1 PPARG RARA RXRA TRAIP TRIM21 VMA22
Entrez ID		3754	247
HPRD ID		04808	04739
Ensembl ID		ENSG00000162975	ENSG00000179593
Uniprot IDs		Q9H3M0	O15296
PDB IDs			4NRE 7LAF 8VIY
Enriched GO Terms of Interacting Partners?		Voltage-gated Potassium Channel Activity Potassium Channel Activity Voltage-gated Potassium Channel Complex Monoatomic Ion Transport Monoatomic Ion Channel Complex Monoatomic Cation Transmembrane Transport Metal Ion Transport Inorganic Cation Transmembrane Transport Potassium Ion Transmembrane Transport Inorganic Ion Transmembrane Transport Monoatomic Ion Channel Activity Transmembrane Transport Potassium Ion Transport Potassium Channel Regulator Activity Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Nitric Oxide Biosynthetic Process Action Potential Regulation Of Biological Quality Protein Homooligomerization Endocannabinoid Signaling Pathway Negative Regulation Of Corticosterone Secretion Cyclic Nucleotide Binding Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Protein Complex Oligomerization Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Regulation Of Potassium Ion Transmembrane Transport Membrane Linoleate 9S-lipoxygenase Activity Linoleate 13S-lipoxygenase Activity Arachidonate 15-lipoxygenase Activity Arachidonate 8(S)-lipoxygenase Activity Lipoxin A4 Biosynthetic Process Cannabinoid Biosynthetic Process Lipoxin Biosynthetic Process Lipoxin A4 Metabolic Process Cannabinoid Signaling Pathway Contact Inhibition Response To Vitamin B1 Regulation Of Metal Ion Transport BH Domain Binding Cellular Response To Morphine Phenylalanine-tRNA Ligase Activity Phenylalanyl-tRNA Aminoacylation Regulation Of Potassium Ion Transport Negative Regulation Of Glucocorticoid Secretion	Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Lipoprotein Transport Nuclear Receptor Activity MRNA Transcription By RNA Polymerase II DNA Binding Domain Binding LBD Domain Binding MRNA Transcription Retinoic Acid-responsive Element Binding Nuclear Protein Quality Control By The Ubiquitin-proteasome System Peroxisome Proliferator Activated Receptor Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Alpha-actinin Binding RNA Polymerase II Transcription Regulator Complex TRNA Threonylcarbamoyladenosine Metabolic Process Hormone-mediated Signaling Pathway Monocyte Differentiation Retinoic Acid Binding Identical Protein Binding Negative Regulation Of MiRNA Transcription Positive Regulation Of Cholesterol Efflux Peptide Binding Cellular Response To Low-density Lipoprotein Particle Stimulus Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Nucleic Acid Metabolic Process Positive Regulation Of Cholesterol Transport Cellular Response To Lipoprotein Particle Stimulus Intracellular Receptor Signaling Pathway Protein Catabolic Process Transcription Coregulator Binding Regulation Of Cholesterol Efflux Macromolecule Metabolic Process Positive Regulation Of Binding Transcription Cis-regulatory Region Binding RNA Metabolic Process Transcription By RNA Polymerase II Regulation Of Cholesterol Transport Sertoli Cell Fate Commitment Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Transcription Positive Regulation Of Lipid Transport Enzyme Binding Regulation Of MiRNA Metabolic Process Negative Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Negative Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Adiponectin Secretion Negative Regulation Of Innate Immune Response Negative Regulation Of Response To Cytokine Stimulus DNA-templated Transcription Response To Retinoic Acid Macromolecule Catabolic Process
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