KCNF1 and KCNH1

Number of citations: 35 (PubMedID 12060745)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		KCNF1	KCNH1
Name		potassium voltage-gated channel modifier subfamily F member 1	potassium voltage-gated channel subfamily H member 1
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex Ciliary Base	Nucleus Nuclear Inner Membrane Endosome Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Axon Dendrite Early Endosome Membrane Monoatomic Ion Channel Complex Presynaptic Membrane Cell Projection Perikaryon Synapse Postsynaptic Membrane Postsynaptic Density Membrane
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Calmodulin Binding Lipid Binding Cyclic Nucleotide Binding Phosphatidylinositol Bisphosphate Binding
	Biological Process	Action Potential Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Transport Protein Homooligomerization Transmembrane Transport Potassium Ion Transmembrane Transport Non-motile Cilium Assembly	Monoatomic Ion Transport Potassium Ion Transport Myoblast Fusion Monoatomic Ion Transmembrane Transport Regulation Of Cell Population Proliferation Regulation Of Membrane Potential Transmembrane Transport Cellular Response To Calcium Ion Potassium Ion Transmembrane Transport
Pathways		Voltage gated Potassium channels	Voltage gated Potassium channels
Drugs		Enflurane Promethazine Miconazole	Enflurane Imipramine Astemizole Promethazine Miconazole
GWAS		No GWAS studies recorded	Blond vs. brown/black hair color ( 30531825 ) Bone mineral density (femoral neck) ( 27424934 ) Bone mineral density (spine) and age at menarche ( 26312577 ) Bone mineral density (total hip) ( 27424934 ) Cancer ( 27197191 ) Cholesterol ( 31902109 ) Circulating vasoactive peptide levels ( 23381795 ) Cobalt levels ( 26025379 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) L1-L4 bone mineral density x serum urate levels interaction ( 34046847 )
Interacting Genes		13 interacting genes: ALOX15B CLPTM1L FARS2 KCNG3 KCNG4 KCNH1 KCNV2 MCL1 OPRM1 SERP1 SLC39A7 TCEA2 TSPO	11 interacting genes: ALG10 CALM1 FASTKD5 KCNB1 KCNC1 KCNF1 KCNH5 MKRN1 MTDH NTAQ1 SDCBP
Entrez ID		3754	3756
HPRD ID		04808	04492
Ensembl ID		ENSG00000162975	ENSG00000143473
Uniprot IDs		Q9H3M0	O95259
PDB IDs		Not available	5J7E
GO Terms Enriched among Interactors		Voltage-gated Potassium Channel Activity Potassium Channel Activity Voltage-gated Potassium Channel Complex Monoatomic Ion Transport Monoatomic Ion Channel Complex Monoatomic Cation Transmembrane Transport Metal Ion Transport Inorganic Cation Transmembrane Transport Potassium Ion Transmembrane Transport Inorganic Ion Transmembrane Transport Monoatomic Ion Channel Activity Transmembrane Transport Potassium Ion Transport Potassium Channel Regulator Activity Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Nitric Oxide Biosynthetic Process Action Potential Regulation Of Biological Quality Protein Homooligomerization Endocannabinoid Signaling Pathway Negative Regulation Of Corticosterone Secretion Cyclic Nucleotide Binding Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Protein Complex Oligomerization Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Regulation Of Potassium Ion Transmembrane Transport Membrane Linoleate 9S-lipoxygenase Activity Linoleate 13S-lipoxygenase Activity Arachidonate 15-lipoxygenase Activity Arachidonate 8(S)-lipoxygenase Activity Lipoxin A4 Biosynthetic Process Cannabinoid Biosynthetic Process Lipoxin Biosynthetic Process Lipoxin A4 Metabolic Process Cannabinoid Signaling Pathway Contact Inhibition Response To Vitamin B1 Regulation Of Metal Ion Transport BH Domain Binding Cellular Response To Morphine Phenylalanine-tRNA Ligase Activity Phenylalanyl-tRNA Aminoacylation Regulation Of Potassium Ion Transport Negative Regulation Of Glucocorticoid Secretion	Voltage-gated Potassium Channel Complex Voltage-gated Potassium Channel Activity Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Monoatomic Ion Channel Complex Transmembrane Transporter Binding Potassium Ion Transmembrane Transport Monoatomic Ion Channel Activity Potassium Ion Transport Regulation Of Membrane Potential Action Potential Calyx Of Held Neuronal Cell Body Membrane Dendrite Membrane Protein Homooligomerization Potassium Channel Regulator Activity Metal Ion Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Protein Complex Oligomerization Regulation Of Action Potential Interleukin-5 Receptor Complex Protein-N-terminal Glutamine Amidohydrolase Activity Inorganic Ion Transmembrane Transport Neural Nucleus Development Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Metal Ion Transport Response To Metal Ion Organelle Localization By Membrane Tethering Positive Regulation Of Exocytosis Regulation Of Potassium Ion Transport Interleukin-5 Receptor Binding Protein-N-terminal Asparagine Amidohydrolase Activity Dolichyl Pyrophosphate Glc2Man9GlcNAc2 Alpha-1,2-glucosyltransferase Activity Membrane Docking Regulation Of Transport Positive Regulation Of Norepinephrine Secretion Monoatomic Ion Transport Globus Pallidus Development Gated Channel Activity Neuron Projection Membrane Regulation Of Monoatomic Ion Transport Negative Regulation Of Transport Clustering Of Voltage-gated Potassium Channels Positive Regulation Of Extracellular Exosome Assembly Syndecan Binding Regulation Of Biological Quality