KCNF1 and OPRM1

Number of citations of the paper that reports this interaction (PMID 23840749)
1

Data Source:
BioGRID (two hybrid)

		KCNF1	OPRM1
Gene Name		potassium channel, voltage gated modifier subfamily F, member 1	opioid receptor, mu 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane	Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Dendrite Membrane Dendrite Cytoplasm Sarcolemma Neuron Projection Perikaryon Membrane Raft
	Molecular Function	Delayed Rectifier Potassium Channel Activity Potassium Channel Activity	G-protein Alpha-subunit Binding G-protein Coupled Receptor Activity Beta-endorphin Receptor Activity Voltage-gated Calcium Channel Activity Protein Binding Protein Domain Specific Binding Filamin Binding G-protein Beta-subunit Binding Morphine Receptor Activity Neuropeptide Binding
	Biological Process	Potassium Ion Transport Synaptic Transmission Regulation Of Ion Transmembrane Transport Protein Homooligomerization Potassium Ion Transmembrane Transport	Acute Inflammatory Response To Antigenic Stimulus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Synaptic Transmission Sensory Perception Locomotory Behavior Negative Regulation Of Cell Proliferation Sensory Perception Of Pain Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Response To Food Positive Regulation Of Appetite Response To Lipopolysaccharide Cellular Response To Stress Wound Healing Response To Cocaine Positive Regulation Of CAMP-mediated Signaling Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Behavioral Response To Ethanol Positive Regulation Of Neurogenesis Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Sensory Perception Of Pain Regulation Of Excitatory Postsynaptic Membrane Potential Negative Regulation Of Wnt Protein Secretion Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Response To Growth Factor Cellular Response To Morphine Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity
Pathways		Potassium Channels Voltage gated Potassium channels	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G-protein activation Class A/1 (Rhodopsin-like receptors) Opioid Signalling G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Tramadol Morphine Codeine Hydromorphone Methadone Oxycodone Levallorphan Butorphanol Propoxyphene Pentazocine Naltrexone Sufentanil Alfentanil Fentanyl Loperamide Nalbuphine Levorphanol Remifentanil Ondansetron Anileridine Buprenorphine Hydrocodone Diphenoxylate Naloxone Oxymorphone Dezocine Levomethadyl Acetate Methadyl Acetate 3-Methylthiofentanyl Dimethylthiambutene Heroin Ethylmorphine Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl Tapentadol Alvimopan Methylnaltrexone
Diseases
GWAS			Coronary heart disease ( 21347282)
Protein-Protein Interactions		5 interactors: KCNG3 KCNG4 KCNH1 KCNV2 OPRM1	23 interactors: ADRBK2 CALM1 COPS5 DNAJB4 DOK4 DOK5 FLNA GNA15 GNAI1 GNAI2 GNAO1 GPRASP1 KCNF1 OPRD1 PLD2 PPL RANBP9 SIAH1 SIAH2 UBC VAPA WLS ZYX
Entrez ID		3754	4988
HPRD ID		04808	02484
Ensembl ID		ENSG00000162975	ENSG00000112038
Uniprot IDs		Q9H3M0	P35372
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Ion Transmembrane Transport Synaptic Transmission Regulation Of Ion Transport Potassium Ion Transmembrane Transport Potassium Ion Transport Metal Ion Transport Cell-cell Signaling Cation Transmembrane Transport Cation Transport Ion Transmembrane Transport Transmembrane Transport Ion Transport Monovalent Inorganic Cation Transport Protein Homooligomerization Protein Oligomerization Negative Regulation Of Wnt Protein Secretion Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Transport Protein Complex Assembly Signaling Cellular Response To Morphine Cell Communication Positive Regulation Of Appetite Cellular Response To Isoquinoline Alkaloid Regulation Of Membrane Potential Negative Regulation Of CAMP-mediated Signaling Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Cytosolic Calcium Ion Concentration Peptidyl-histidine Phosphorylation Opioid Receptor Signaling Pathway Behavioral Response To Ethanol Positive Regulation Of CAMP-mediated Signaling Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Nitric Oxide Biosynthetic Process Phosphorelay Signal Transduction System Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Response To Food Cellular Response To Ammonium Ion Cellular Component Assembly Regulation Of Appetite Myoblast Fusion Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Negative Regulation Of Adenylate Cyclase Activity Regulation Of CAMP-mediated Signaling Response To Food Negative Regulation Of Lyase Activity Regulation Of Sensory Perception Of Pain Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Inflammatory Response To Antigenic Stimulus	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Signaling Cell Communication Cell Surface Receptor Signaling Pathway Platelet Activation Signal Transduction Regulation Of Signal Transduction Response To Stimulus Dopamine Receptor Signaling Pathway Regulation Of Signaling Synaptic Transmission Cell-cell Signaling Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Calcium Ion Transport Cellular Response To Stimulus Blood Coagulation Hemostasis Establishment Of Localization In Cell Regulation Of I-kappaB Kinase/NF-kappaB Signaling Receptor Metabolic Process G-protein Coupled Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Cellular Localization Regulation Of Cellular Process Regulation Of Ion Transport Vesicle-mediated Transport Cell Activation Cytoplasmic Transport Response To Wounding Cell Projection Organization Negative Regulation Of Signaling Response To Stress Negative Regulation Of Calcium Ion Transport Receptor Internalization Transport Nervous System Development Neuron Projection Development Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Endosomal Transport Membrane Organization Cellular Process Activation Of Phospholipase C Activity
Tagcloud ?			13qter 9p acp5 cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgam itgbeta2 linkage mapping mu opioid pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1
Tagcloud (Difference) ?			13qter 9p acp5 cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgam itgbeta2 linkage mapping mu opioid pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1
Tagcloud (Intersection) ?