KCNB1 and VAPB

Number of citations of the paper that reports this interaction (PubMedID 29941597)
64

Data Source:
BioGRID (fluorescent resonance energy transfer)

		KCNB1	VAPB
Description		potassium voltage-gated channel subfamily B member 1	VAMP associated protein B and C
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GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Apical Plasma Membrane Lateral Plasma Membrane Axon Dendrite Dendrite Membrane Neuronal Cell Body Membrane Monoatomic Ion Channel Complex Sarcolemma Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Cholinergic Synapse Postsynaptic Specialization Membrane Proximal Dendrite	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Endoplasmic Reticulum Exit Site Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	SNARE Binding Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Potassium Channel Regulator Activity Transmembrane Transporter Binding Protein Heterodimerization Activity	Protein Binding Microtubule Binding Enzyme Binding FFAT Motif Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Cadherin Binding Protein Heterodimerization Activity Beta-tubulin Binding
	Biological Process	Action Potential Monoatomic Ion Transport Potassium Ion Transport Exocytosis Vesicle Docking Involved In Exocytosis Glutamate Receptor Signaling Pathway Positive Regulation Of Norepinephrine Secretion Cellular Response To Nutrient Levels Positive Regulation Of Catecholamine Secretion Monoatomic Ion Transmembrane Transport Glucose Homeostasis Clustering Of Voltage-gated Potassium Channels Positive Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Insulin Secretion Response To Axon Injury Protein Homooligomerization Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To Glucose Stimulus Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Potassium Ion Export Across Plasma Membrane Regulation Of Action Potential Positive Regulation Of Long-term Synaptic Depression Response To L-glutamate Regulation Of Motor Neuron Apoptotic Process	Intracellular Calcium Ion Homeostasis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Response To Unfolded Protein Endoplasmic Reticulum Organization Viral Release From Host Cell Cholesterol Transport Endoplasmic Reticulum Unfolded Protein Response IRE1-mediated Unfolded Protein Response Suppression Of Viral Release By Host Host-mediated Suppression Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Host-mediated Perturbation Of Viral RNA Genome Replication Positive Regulation Of Viral Genome Replication Negative Regulation By Virus Of Viral Protein Levels In Host Cell Endoplasmic Reticulum-plasma Membrane Tethering COPII-coated Vesicle Budding Endoplasmic Reticulum Membrane Organization
Pathways		Voltage gated Potassium channels Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	Sphingolipid de novo biosynthesis RHOA GTPase cycle RHOC GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle
Drugs		Enflurane Promethazine Miconazole Dalfampridine
Diseases			Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD) Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 34002096) Diastolic blood pressure ( 30224653) Height ( 28552196) Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) White matter hyperintensity burden ( 25663218)
Interacting Genes		19 interacting genes: CALM1 KCNB2 KCNE5 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNS3 KCNV1 KCNV2 NEDD4L PTK2 PTPRE SNAP25 SRC STX1A VAPA VAPB	49 interacting genes: AIG1 AQP2 AQP6 BIK CD79A CFTR CYB561 CYBRD1 EBAG9 EBP ELOVL4 FAM174A GJA8 GLP1R GPR25 HSD17B13 JAGN1 KCNB1 MAILR MTNR1A OSBP OSBPL2 PTGES REEP4 RETREG3 RMDN2 RNASEK RNF111 SCN3B SLC10A1 SLC18A1 SLC22A1 SQSTM1 STARD3 STX1A STX2 STX4 STX5 TIMMDC1 TMEM101 TMX2 TTC39B USP20 VAMP1 VAMP2 VHL VKORC1 ZBTB22 ZDHHC15
Entrez ID		3745	9217
HPRD ID		08983	09300
Ensembl ID		ENSG00000158445	ENSG00000124164
Uniprot IDs		Q14721	O95292 Q53XM7
PDB IDs		7RE5 7SPD	2MDK 3IKK
Enriched GO Terms of Interacting Partners?		Voltage-gated Potassium Channel Complex Voltage-gated Potassium Channel Activity Potassium Channel Regulator Activity Regulation Of Membrane Potential Potassium Ion Transmembrane Transport Potassium Ion Transport Action Potential Potassium Channel Activity Monoatomic Ion Channel Complex Monoatomic Ion Channel Activity Metal Ion Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Inorganic Ion Transmembrane Transport Regulation Of Biological Quality Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Transport Plasma Membrane Protein Homooligomerization Monoatomic Ion Transport Regulation Of Potassium Ion Transmembrane Transport Protein Complex Oligomerization Transmembrane Transport Protein-containing Complex Assembly Regulation Of Metal Ion Transport Protein-containing Complex Organization Transmembrane Transporter Binding Regulation Of Monoatomic Ion Transport Delayed Rectifier Potassium Channel Activity Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Organelle Localization By Membrane Tethering Membrane Docking Regulation Of Transport Membrane Cellular Component Assembly FFAT Motif Binding Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Caveolin-mediated Endocytosis Endoplasmic Reticulum Localization Signal Complex Assembly Host-mediated Activation Of Viral Genome Replication Negative Regulation Of Cation Transmembrane Transport Host-mediated Perturbation Of Viral Genome Replication Negative Regulation Of Monoatomic Ion Transmembrane Transport Synaptic Vesicle Docking	Membrane SNAP Receptor Activity SNARE Complex Organic Hydroxy Compound Transport Vesicle Docking SNARE Binding SNARE Complex Assembly Organelle Localization By Membrane Tethering Membrane Docking Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Vesicle Organization Endoplasmic Reticulum Membrane Membrane Fusion Regulation Of Insulin Secretion Endomembrane System Regulation Of Hormone Secretion Membrane Organization Endoplasmic Reticulum Establishment Of Localization In Cell Regulation Of Hormone Levels Regulation Of Peptide Hormone Secretion Ascorbate Homeostasis Exocytosis Positive Regulation Of Norepinephrine Secretion Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cholesterol Transport Transmembrane Monodehydroascorbate Reductase Activity Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Water Transport Transmembrane Transport Basolateral Plasma Membrane Sterol Transport Clathrin-sculpted Monoamine Transport Vesicle Membrane Positive Regulation Of Exocytosis Regulation Of Protein Secretion Protein Binding Cytoplasmic Vesicle Cornified Envelope Assembly Norepinephrine Uptake Secretion By Cell Fluid Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Chloride Channel Inhibitor Activity Neurotransmitter Transport Positive Regulation Of Secretion By Cell Regulation Of Secretion By Cell
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