KCNB1 and KCNB2

Number of citations of the paper that reports this interaction (PubMedID 19074135)
0

Data Source:
BioGRID (two hybrid)

		KCNB1	KCNB2
Description		potassium voltage-gated channel subfamily B member 1	potassium voltage-gated channel subfamily B member 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Apical Plasma Membrane Lateral Plasma Membrane Axon Dendrite Dendrite Membrane Neuronal Cell Body Membrane Monoatomic Ion Channel Complex Sarcolemma Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Cholinergic Synapse Postsynaptic Specialization Membrane Proximal Dendrite	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Dendrite Neuronal Cell Body Membrane Monoatomic Ion Channel Complex Cell Projection Neuronal Cell Body Perikaryon
	Molecular Function	SNARE Binding Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Potassium Channel Regulator Activity Transmembrane Transporter Binding Protein Heterodimerization Activity	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Protein Heterodimerization Activity
	Biological Process	Action Potential Monoatomic Ion Transport Potassium Ion Transport Exocytosis Vesicle Docking Involved In Exocytosis Glutamate Receptor Signaling Pathway Positive Regulation Of Norepinephrine Secretion Cellular Response To Nutrient Levels Positive Regulation Of Catecholamine Secretion Monoatomic Ion Transmembrane Transport Glucose Homeostasis Clustering Of Voltage-gated Potassium Channels Positive Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Insulin Secretion Response To Axon Injury Protein Homooligomerization Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To Glucose Stimulus Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Potassium Ion Export Across Plasma Membrane Regulation Of Action Potential Positive Regulation Of Long-term Synaptic Depression Response To L-glutamate Regulation Of Motor Neuron Apoptotic Process	Action Potential Monoatomic Ion Transport Potassium Ion Transport Regulation Of Smooth Muscle Contraction Monoatomic Ion Transmembrane Transport Protein Homooligomerization Transmembrane Transport Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane
Pathways		Voltage gated Potassium channels Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	Voltage gated Potassium channels
Drugs		Enflurane Promethazine Miconazole Dalfampridine	Enflurane Promethazine Miconazole Dalfampridine
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 34002096) Diastolic blood pressure ( 30224653) Height ( 28552196) Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) White matter hyperintensity burden ( 25663218)	Adult body size ( 32376654) Chronotype ( 30696823) Cognitive performance ( 20125193) Coronary artery disease in type 1 diabetes ( 29695241) Crohn's disease ( 22412388) Echocardiographic traits ( 17903301) HDL cholesterol levels ( 32203549) Multiple sclerosis (age of onset) ( 19010793) Tea consumption ( 31046077) Type 2 diabetes ( 32499647)
Interacting Genes		19 interacting genes: CALM1 KCNB2 KCNE5 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNS3 KCNV1 KCNV2 NEDD4L PTK2 PTPRE SNAP25 SRC STX1A VAPA VAPB	4 interacting genes: KCNB1 KCNG3 KCNV1 VAPA
Entrez ID		3745	9312
HPRD ID		08983	09666
Ensembl ID		ENSG00000158445	ENSG00000182674
Uniprot IDs		Q14721	Q92953
PDB IDs		7RE5 7SPD
Enriched GO Terms of Interacting Partners?		Voltage-gated Potassium Channel Complex Voltage-gated Potassium Channel Activity Potassium Channel Regulator Activity Regulation Of Membrane Potential Potassium Ion Transmembrane Transport Potassium Ion Transport Action Potential Potassium Channel Activity Monoatomic Ion Channel Complex Monoatomic Ion Channel Activity Metal Ion Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Inorganic Ion Transmembrane Transport Regulation Of Biological Quality Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Transport Plasma Membrane Protein Homooligomerization Monoatomic Ion Transport Regulation Of Potassium Ion Transmembrane Transport Protein Complex Oligomerization Transmembrane Transport Protein-containing Complex Assembly Regulation Of Metal Ion Transport Protein-containing Complex Organization Transmembrane Transporter Binding Regulation Of Monoatomic Ion Transport Delayed Rectifier Potassium Channel Activity Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Organelle Localization By Membrane Tethering Membrane Docking Regulation Of Transport Membrane Cellular Component Assembly FFAT Motif Binding Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Caveolin-mediated Endocytosis Endoplasmic Reticulum Localization Signal Complex Assembly Host-mediated Activation Of Viral Genome Replication Negative Regulation Of Cation Transmembrane Transport Host-mediated Perturbation Of Viral Genome Replication Negative Regulation Of Monoatomic Ion Transmembrane Transport Synaptic Vesicle Docking	Potassium Channel Regulator Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Voltage-gated Potassium Channel Complex Action Potential Monoatomic Ion Channel Complex Potassium Ion Transmembrane Transport Monoatomic Ion Channel Activity Potassium Ion Transport Protein Homooligomerization Protein Complex Oligomerization Regulation Of Membrane Potential Organelle Localization By Membrane Tethering Membrane Docking Metal Ion Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Monoatomic Ion Transport Positive Regulation Of Norepinephrine Secretion FFAT Motif Binding Clustering Of Voltage-gated Potassium Channels Transmembrane Transport COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Protein-containing Complex Assembly Positive Regulation Of Long-term Synaptic Depression Endoplasmic Reticulum Localization Proximal Dendrite Protein-containing Complex Organization Cholinergic Synapse Neuronal Ion Channel Clustering Protein Heterodimerization Activity Host-mediated Activation Of Viral Genome Replication Sphingomyelin Biosynthetic Process Host-mediated Perturbation Of Viral Genome Replication Regulation Of Norepinephrine Secretion Positive Regulation Of Catecholamine Secretion Protein Folding In Endoplasmic Reticulum Host-mediated Suppression Of Viral Genome Replication Ion Channel Inhibitor Activity Regulation Of Motor Neuron Apoptotic Process Regulation Of Long-term Synaptic Depression Potassium Ion Export Across Plasma Membrane Positive Regulation Of Calcium Ion-dependent Exocytosis Outward Rectifier Potassium Channel Activity Protein Localization To Endoplasmic Reticulum Ceramide Transport
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