KCNB1 and KCNH1

Number of citations of the paper that reports this interaction (PMID 12060745)
33

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		KCNB1	KCNH1
Gene Name		potassium channel, voltage gated Shab related subfamily B, member 1	potassium channel, voltage gated eag related subfamily H, member 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Dendrite Dendrite Membrane Neuronal Cell Body Membrane Postsynaptic Membrane	Nuclear Inner Membrane Nucleoplasm Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex
	Molecular Function	Delayed Rectifier Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Protein N-terminus Binding	Phosphorelay Sensor Kinase Activity Delayed Rectifier Potassium Channel Activity Protein Binding Calmodulin Binding
	Biological Process	Energy Reserve Metabolic Process Synaptic Transmission Regulation Of Ion Transmembrane Transport Small Molecule Metabolic Process Regulation Of Insulin Secretion Protein Homooligomerization Potassium Ion Transmembrane Transport	Phosphorelay Signal Transduction System Potassium Ion Transport Synaptic Transmission Myoblast Fusion Signal Transduction By Phosphorylation Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Potassium Ion Transmembrane Transport
Pathways		Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Regulation of insulin secretion Potassium Channels Voltage gated Potassium channels	Potassium Channels Voltage gated Potassium channels
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Circulating vasoactive peptide levels ( 23381795)
Protein-Protein Interactions		14 interactors: KCNB2 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNS3 KCNV1 KCNV2 NEDD4L PTPRE SNAP25 SRC STX1A	9 interactors: ALG10 CALM1 FASTKD5 KCNB1 KCNC1 KCNF1 KCNH5 SDCBP WDYHV1
Entrez ID		3745	3756
HPRD ID		08983	04492
Ensembl ID
Uniprot IDs		Q14721	O95259
PDB IDs
Enriched GO Terms of Interacting Partners?		Potassium Ion Transmembrane Transport Potassium Ion Transport Synaptic Transmission Regulation Of Ion Transmembrane Transport Cell-cell Signaling Regulation Of Ion Transport Monovalent Inorganic Cation Transport Protein Homooligomerization Ion Transport Metal Ion Transport Protein Complex Assembly Protein Oligomerization Cation Transport Ion Transmembrane Transport Cation Transmembrane Transport Signaling Cell Communication Transmembrane Transport Cellular Component Assembly Transport Energy Reserve Metabolic Process Regulation Of Protein Secretion Regulation Of Protein Localization Regulation Of Caveolin-mediated Endocytosis Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Synaptic Vesicle Docking Regulation Of Hormone Secretion Regulation Of Cellular Localization Synaptic Vesicle Fusion To Presynaptic Membrane Regulation Of Protein Transport Energy Derivation By Oxidation Of Organic Compounds Regulation Of Secretion Regulation Of Establishment Of Protein Localization Regulation Of Cellular Process Generation Of Precursor Metabolites And Energy Glutamate Secretion Regulation Of Membrane Depolarization Vesicle Fusion Synaptic Vesicle Exocytosis Regulation Of Membrane Potential Regulation Of Cell Junction Assembly Acid Secretion Vesicle Docking Involved In Exocytosis Regulation Of Insulin Receptor Signaling Pathway Regulation Of Signaling Organelle Fusion Regulation Of Cellular Response To Insulin Stimulus Vesicle Docking Dicarboxylic Acid Transport	Synaptic Transmission Regulation Of Ion Transmembrane Transport Cell-cell Signaling Potassium Ion Transmembrane Transport Potassium Ion Transport Regulation Of Ion Transport Monovalent Inorganic Cation Transport Protein Homooligomerization Energy Derivation By Oxidation Of Organic Compounds Metal Ion Transport Cation Transmembrane Transport Generation Of Precursor Metabolites And Energy Protein Oligomerization Cation Transport Ion Transmembrane Transport Energy Reserve Metabolic Process Positive Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Transmembrane Transport Ion Transport Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Component Assembly Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Peptidyl-histidine Phosphorylation Transport Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Detection Of Calcium Ion Substrate-dependent Cell Migration, Cell Extension Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Protein Complex Assembly Regulation Of Cellular Localization Phosphorelay Signal Transduction System Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-threonine Phosphorylation Signaling Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Cell Communication Polysaccharide Catabolic Process
Tagcloud ?		3xtg abundantly accordingly alanine argues c113s c73a caenorhabditis channels ectopic elegans exacerbated homolog insults invertebrate kv2 kvs mimics mutating neuropathy neuroprotective oligomerization oligomers oxidant oxidation oxidizing potassium protected underscore	1c currents eag eag1 elk erg erg1 governed heag1 herg imbalance immuno itim kcnh2 kv10 kv11 kv12 nothing phosphatases pp1 prototypes ptp ptpn6 qt shp src40 subfamilies superfamily underlie
Tagcloud (Difference) ?		3xtg abundantly accordingly alanine argues c113s c73a caenorhabditis channels ectopic elegans exacerbated homolog insults invertebrate kv2 kvs mimics mutating neuropathy neuroprotective oligomerization oligomers oxidant oxidation oxidizing potassium protected underscore	1c currents eag eag1 elk erg erg1 governed heag1 herg imbalance immuno itim kcnh2 kv10 kv11 kv12 nothing phosphatases pp1 prototypes ptp ptpn6 qt shp src40 subfamilies superfamily underlie
Tagcloud (Intersection) ?