KCNB1 and KCNS3

Number of citations of the paper that reports this interaction (PubMedID 9362476)
46

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		KCNB1	KCNS3
Description		potassium voltage-gated channel subfamily B member 1	potassium voltage-gated channel modifier subfamily S member 3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Apical Plasma Membrane Lateral Plasma Membrane Axon Dendrite Dendrite Membrane Neuronal Cell Body Membrane Monoatomic Ion Channel Complex Sarcolemma Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Cholinergic Synapse Postsynaptic Specialization Membrane Proximal Dendrite	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex
	Molecular Function	SNARE Binding Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Potassium Channel Regulator Activity Transmembrane Transporter Binding Protein Heterodimerization Activity	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Potassium Channel Regulator Activity
	Biological Process	Action Potential Monoatomic Ion Transport Potassium Ion Transport Exocytosis Vesicle Docking Involved In Exocytosis Glutamate Receptor Signaling Pathway Positive Regulation Of Norepinephrine Secretion Cellular Response To Nutrient Levels Positive Regulation Of Catecholamine Secretion Monoatomic Ion Transmembrane Transport Glucose Homeostasis Clustering Of Voltage-gated Potassium Channels Positive Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Insulin Secretion Response To Axon Injury Protein Homooligomerization Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To Glucose Stimulus Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Potassium Ion Export Across Plasma Membrane Regulation Of Action Potential Positive Regulation Of Long-term Synaptic Depression Response To L-glutamate Regulation Of Motor Neuron Apoptotic Process	Action Potential Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Protein Homooligomerization Transmembrane Transport Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport
Pathways		Voltage gated Potassium channels Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	Voltage gated Potassium channels Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Drugs		Enflurane Promethazine Miconazole Dalfampridine	Enflurane Promethazine Miconazole
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 34002096) Diastolic blood pressure ( 30224653) Height ( 28552196) Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) White matter hyperintensity burden ( 25663218)	Body fat percentage ( 31752434) Colonoscopy-negative controls vs population controls ( 29228715) Colorectal cancer ( 29228715) Femur bone mineral density x serum urate levels interaction ( 34046847) FEV1 ( 30804560) Height ( 28552196 31562340) Hip circumference adjusted for BMI ( 28552196) Low density lipoprotein cholesterol levels ( 33339817) Lung function (FEV1) ( 26635082 28166213) Lung function (FEV1/FVC) ( 30804560 26635082 28166213) Lung function (FVC) ( 30804560) Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics ( 32958699) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Peak expiratory flow ( 30804560) Physiological traits ( 31902109) QT interval (sulfonylurea treatment interaction) ( 27958378) Systolic blood pressure night-to-day ratio in hypertension ( 29973135) Total cholesterol levels ( 33339817) Urate levels in obese individuals ( 25811787)
Interacting Genes		19 interacting genes: CALM1 KCNB2 KCNE5 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNS3 KCNV1 KCNV2 NEDD4L PTK2 PTPRE SNAP25 SRC STX1A VAPA VAPB	1 interacting genes: KCNB1
Entrez ID		3745	3790
HPRD ID		08983	04865
Ensembl ID		ENSG00000158445	ENSG00000170745
Uniprot IDs		Q14721	Q9BQ31
PDB IDs		7RE5 7SPD
Enriched GO Terms of Interacting Partners?		Voltage-gated Potassium Channel Complex Voltage-gated Potassium Channel Activity Potassium Channel Regulator Activity Regulation Of Membrane Potential Potassium Ion Transmembrane Transport Potassium Ion Transport Action Potential Potassium Channel Activity Monoatomic Ion Channel Complex Monoatomic Ion Channel Activity Metal Ion Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Inorganic Ion Transmembrane Transport Regulation Of Biological Quality Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Transport Plasma Membrane Protein Homooligomerization Monoatomic Ion Transport Regulation Of Potassium Ion Transmembrane Transport Protein Complex Oligomerization Transmembrane Transport Protein-containing Complex Assembly Regulation Of Metal Ion Transport Protein-containing Complex Organization Transmembrane Transporter Binding Regulation Of Monoatomic Ion Transport Delayed Rectifier Potassium Channel Activity Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Organelle Localization By Membrane Tethering Membrane Docking Regulation Of Transport Membrane Cellular Component Assembly FFAT Motif Binding Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Caveolin-mediated Endocytosis Endoplasmic Reticulum Localization Signal Complex Assembly Host-mediated Activation Of Viral Genome Replication Negative Regulation Of Cation Transmembrane Transport Host-mediated Perturbation Of Viral Genome Replication Negative Regulation Of Monoatomic Ion Transmembrane Transport Synaptic Vesicle Docking	Regulation Of Motor Neuron Apoptotic Process Regulation Of Norepinephrine Secretion Clustering Of Voltage-gated Potassium Channels Positive Regulation Of Catecholamine Secretion Regulation Of Long-term Synaptic Depression Positive Regulation Of Long-term Synaptic Depression Cholinergic Synapse Potassium Ion Export Across Plasma Membrane Neuronal Ion Channel Clustering Positive Regulation Of Calcium Ion-dependent Exocytosis Proximal Dendrite Outward Rectifier Potassium Channel Activity Positive Regulation Of Norepinephrine Secretion Response To L-glutamate Delayed Rectifier Potassium Channel Activity Neuronal Cell Body Membrane Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of Insulin Secretion Regulation Of Protein Targeting To Membrane Cellular Response To Glucose Stimulus Response To Axon Injury Positive Regulation Of Regulated Secretory Pathway Vesicle Docking Involved In Exocytosis Dendrite Membrane Negative Regulation Of Hormone Secretion Export Across Plasma Membrane Potassium Channel Regulator Activity Regulation Of Catecholamine Secretion Voltage-gated Potassium Channel Activity Glutamate Receptor Signaling Pathway Regulation Of Calcium Ion-dependent Exocytosis Cellular Response To Carbohydrate Stimulus Negative Regulation Of Peptide Secretion Negative Regulation Of Protein Secretion Lateral Plasma Membrane Potassium Channel Activity Regulation Of Action Potential Postsynaptic Specialization Membrane SNARE Binding Regulation Of Amine Transport Vesicle Docking Voltage-gated Potassium Channel Complex Cellular Response To Calcium Ion Organelle Localization By Membrane Tethering Positive Regulation Of Exocytosis Membrane Docking Intracellular Glucose Homeostasis Sarcolemma Action Potential Response To Amino Acid
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