KCNB1 and SNAP25

Number of citations of the paper that reports this interaction (PMID 12403834)
13

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		KCNB1	SNAP25
Gene Name		potassium channel, voltage gated Shab related subfamily B, member 1	synaptosomal-associated protein, 25kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Dendrite Dendrite Membrane Neuronal Cell Body Membrane Postsynaptic Membrane	Cytoplasm Trans-Golgi Network Cytosol Plasma Membrane Membrane Cell Junction Growth Cone BLOC-1 Complex SNARE Complex Vesicle Presynaptic Membrane Neuron Projection Perinuclear Region Of Cytoplasm Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex
	Molecular Function	Delayed Rectifier Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Protein N-terminus Binding	SNAP Receptor Activity Protein Binding Syntaxin-1 Binding Calcium-dependent Protein Binding
	Biological Process	Energy Reserve Metabolic Process Synaptic Transmission Regulation Of Ion Transmembrane Transport Small Molecule Metabolic Process Regulation Of Insulin Secretion Protein Homooligomerization Potassium Ion Transmembrane Transport	Neurotransmitter Uptake Energy Reserve Metabolic Process Synaptic Transmission Neurotransmitter Secretion Pathogenesis Regulation Of Neuron Projection Development Glutamate Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Membrane Small Molecule Metabolic Process Regulation Of Insulin Secretion Long-term Synaptic Potentiation Regulation Of Establishment Of Protein Localization
Pathways		Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Regulation of insulin secretion Potassium Channels Voltage gated Potassium channels	Dopamine Neurotransmitter Release Cycle Integration of energy metabolism Toxicity of botulinum toxin type E (BoNT/E) Toxicity of botulinum toxin type A (BoNT/A) Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Toxicity of botulinum toxin type C (BoNT/C) Norepinephrine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Neurotoxicity of clostridium toxins Serotonin Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs			Botulinum Toxin Type A
Diseases
GWAS		Obesity-related traits ( 23251661)	Cardiac hypertrophy ( 21348951)
Protein-Protein Interactions		14 interactors: KCNB2 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNS3 KCNV1 KCNV2 NEDD4L PTPRE SNAP25 SRC STX1A	34 interactors: APP CCDC53 CENPF CPLX1 DNM1 GOSR1 HGS ITSN1 KCNB1 KIF5B NAPA PRKACA PRKCA PRRT2 RIMS1 SCAMP1 SNAPIN SRCIN1 STX11 STX12 STX1A STX2 STX3 STX4 STX5 STXBP6 SYT1 SYT3 SYT9 TRIM9 VAMP2 VAMP7 VAMP8 ZDHHC17
Entrez ID		3745	6616
HPRD ID		08983	02637
Ensembl ID			ENSG00000132639
Uniprot IDs		Q14721	P60880
PDB IDs			1KIL 1XTG 3RK2 3RK3 3RL0 3ZUR
Enriched GO Terms of Interacting Partners?		Potassium Ion Transmembrane Transport Potassium Ion Transport Synaptic Transmission Regulation Of Ion Transmembrane Transport Cell-cell Signaling Regulation Of Ion Transport Monovalent Inorganic Cation Transport Protein Homooligomerization Ion Transport Metal Ion Transport Protein Complex Assembly Protein Oligomerization Cation Transport Ion Transmembrane Transport Cation Transmembrane Transport Signaling Cell Communication Transmembrane Transport Cellular Component Assembly Transport Energy Reserve Metabolic Process Regulation Of Protein Secretion Regulation Of Protein Localization Regulation Of Caveolin-mediated Endocytosis Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Synaptic Vesicle Docking Regulation Of Hormone Secretion Regulation Of Cellular Localization Synaptic Vesicle Fusion To Presynaptic Membrane Regulation Of Protein Transport Energy Derivation By Oxidation Of Organic Compounds Regulation Of Secretion Regulation Of Establishment Of Protein Localization Regulation Of Cellular Process Generation Of Precursor Metabolites And Energy Glutamate Secretion Regulation Of Membrane Depolarization Vesicle Fusion Synaptic Vesicle Exocytosis Regulation Of Membrane Potential Regulation Of Cell Junction Assembly Acid Secretion Vesicle Docking Involved In Exocytosis Regulation Of Insulin Receptor Signaling Pathway Regulation Of Signaling Organelle Fusion Regulation Of Cellular Response To Insulin Stimulus Vesicle Docking Dicarboxylic Acid Transport	Membrane Fusion Exocytosis Vesicle-mediated Transport Vesicle Fusion Synaptic Vesicle Exocytosis Synaptic Vesicle Transport Establishment Of Localization In Cell Secretion By Cell Organelle Fusion Establishment Of Vesicle Localization Vesicle Localization Regulation Of Exocytosis Secretion Neurotransmitter Secretion Cellular Localization Transport Establishment Of Organelle Localization Regulation Of Cellular Localization Synaptic Transmission Regulation Of Neurotransmitter Levels Regulation Of Secretion Organelle Localization Neurotransmitter Transport Membrane Organization Regulation Of Vesicle-mediated Transport Synaptic Vesicle Fusion To Presynaptic Membrane Protein Transport Vesicle Organization Establishment Of Protein Localization Cell-cell Signaling Vesicle Docking Intracellular Transport Membrane Docking Protein Localization Positive Regulation Of Exocytosis Calcium Ion-dependent Exocytosis Regulation Of Hormone Secretion Intracellular Protein Transport Regulation Of Cellular Component Organization Positive Regulation Of Transport Glutamate Secretion Regulation Of Synaptic Transmission Golgi Vesicle Transport Post-Golgi Vesicle-mediated Transport Regulation Of Protein Localization Positive Regulation Of Synaptic Transmission Regulation Of Insulin Secretion Cellular Protein Localization Regulation Of Peptide Hormone Secretion Acid Secretion
Tagcloud ?		3xtg abundantly accordingly alanine argues c113s c73a caenorhabditis channels ectopic elegans exacerbated homolog insults invertebrate kv2 kvs mimics mutating neuropathy neuroprotective oligomerization oligomers oxidant oxidation oxidizing potassium protected underscore	anterograde axonal axons blunt breakdown bulbous bulbs caudate circumscribed disorganized immunocytochemical immunoreactivity insult map5 mca neurofilament nf68kd nonischemic occlusion permeating precedes reminiscent roughened sequalae subcortical swellings synaptosomal territory tracts
Tagcloud (Difference) ?		3xtg abundantly accordingly alanine argues c113s c73a caenorhabditis channels ectopic elegans exacerbated homolog insults invertebrate kv2 kvs mimics mutating neuropathy neuroprotective oligomerization oligomers oxidant oxidation oxidizing potassium protected underscore	anterograde axonal axons blunt breakdown bulbous bulbs caudate circumscribed disorganized immunocytochemical immunoreactivity insult map5 mca neurofilament nf68kd nonischemic occlusion permeating precedes reminiscent roughened sequalae subcortical swellings synaptosomal territory tracts
Tagcloud (Intersection) ?