ICAM4 and RHAG

Number of citations: 0 (PubMedID 8563755)
Data Source: HPRD (in vivo)

		ICAM4	RHAG
Name		intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	Rh associated glycoprotein
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane	Plasma Membrane Membrane Ankyrin-1 Complex
	Molecular Function	Integrin Binding Protein Binding	Protein Binding Ammonium Channel Activity Methylammonium Transmembrane Transporter Activity Leak Channel Activity Ankyrin Binding Carbon Dioxide Transmembrane Transporter Activity
	Biological Process	Cell Adhesion Cell-cell Adhesion	Intracellular Monoatomic Ion Homeostasis Carbon Dioxide Transport Bicarbonate Transport Carbon Dioxide Transmembrane Transport Erythrocyte Development Multicellular Organismal-level Iron Ion Homeostasis Ammonium Transmembrane Transport Methylammonium Transmembrane Transport Ammonium Homeostasis Inorganic Cation Transmembrane Transport
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions	Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Rhesus glycoproteins mediate ammonium transport Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN)
Diseases		None	Hereditary stomatocytosis (HSt); Dehydrated hereditary stomatocytosis (DHS); Overhydrated hereditary stomatocytosis (OHS); Familial pseudohyperkalemia (FP)
GWAS		Blood protein levels ( 30072576 )	Alcohol dependence ( 26365420 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 )
Novel Interactors		1 novel interactors: AKAP8L	None recorded
Interacting Genes		14 interacting genes: CREB3 CYSRT1 ITGA4 ITGAM ITGAV ITGB1 ITGB2 KRT31 KRT34 KRTAP5-9 MTUS2 NBPF19 NOTCH2NLA RHAG	11 interacting genes: ANK1 CD47 CREB3L3 ERGIC3 FAM209A GYPB ICAM4 LMNA SLC4A1 TEX29 UNC93A
Entrez ID		3386	6005
HPRD ID		00198	01582
Ensembl ID		ENSG00000105371	ENSG00000112077
Uniprot IDs		Q14773 U5U6P8	Q02094 Q96E98
PDB IDs		Not available	7UZQ 7V0K 7V0S 8CRT 8CS9 8CSL 8CSX 8CTE
GO Terms Enriched among Interactors		Integrin Complex Heterotypic Cell-cell Adhesion C-X3-C Chemokine Binding Cell Adhesion Mediated By Integrin Integrin-mediated Signaling Pathway Cell-matrix Adhesion Integrin Binding Cell-substrate Adhesion Integrin AlphaM-beta2 Complex Integrin Alphav-beta1 Complex Fibronectin Binding Integrin Alpha4-beta1 Complex Positive Regulation Of Neutrophil Degranulation Endodermal Cell Differentiation Negative Regulation Of Dopamine Metabolic Process Epidermis Development Negative Regulation Of Catecholamine Metabolic Process Receptor-mediated Endocytosis Leukocyte Cell-cell Adhesion Cell-cell Adhesion Mediated By Integrin Regulation Of Neutrophil Degranulation Coreceptor Activity Tissue Development Endocytosis Complement Component C3b Binding Cell-cell Adhesion Specific Granule Membrane Negative Regulation Of Vasoconstriction Signaling Receptor Activity Cell Adhesion Molecule Binding Phagocytosis Wound Healing, Spreading Of Epidermal Cells Import Into Cell Leukocyte Tethering Or Rolling Regulation Of Dopamine Metabolic Process Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Cell Surface Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell External Side Of Plasma Membrane Cellular Developmental Process Cargo Receptor Activity Positive Regulation Of Protein Targeting To Membrane Amyloid-beta Clearance Regulation Of Superoxide Metabolic Process Wound Healing, Spreading Of Cells Microglial Cell Activation Phagocytosis, Engulfment Cell Differentiation	Ankyrin-1 Complex