ICAM4 and ITGAV

Number of citations of the paper that reports this interaction (PMID 11435317)
8

Data Source:
HPRD (in vitro)

		ICAM4	ITGAV
Gene Name		intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	integrin, alpha V
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Lamellipodium Membrane Filopodium Membrane Microvillus Membrane Ruffle Membrane Integrin Alphav-beta3 Complex Integrin Alphav-beta5 Complex Integrin Alphav-beta8 Complex Alphav-beta3 Integrin-IGF-1-IGF1R Complex Phagocytic Vesicle Extracellular Vesicular Exosome
	Molecular Function	Integrin Binding	Virus Receptor Activity Opsonin Binding Fibronectin Binding Protease Binding Protein Kinase C Binding Voltage-gated Calcium Channel Activity Protein Binding Insulin-like Growth Factor I Binding Metal Ion Binding Transforming Growth Factor Beta Binding Extracellular Matrix Binding Extracellular Matrix Protein Binding
	Biological Process	Cell Adhesion Single Organismal Cell-cell Adhesion Extracellular Matrix Organization Regulation Of Immune Response	Angiogenesis Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Positive Regulation Of Cell Proliferation Response To Virus Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Cell Growth Cell Migration Extracellular Matrix Organization Positive Regulation Of Cell Migration Cell-substrate Adhesion Negative Regulation Of Lipid Transport Positive Regulation Of Osteoblast Proliferation Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Apolipoprotein A-I-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Apoptotic Cell Clearance Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Cell Adhesion Viral Entry Into Host Cell Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Lipoprotein Metabolic Process Regulation Of Phagocytosis Leukocyte Migration Negative Chemotaxis Entry Of Symbiont Into Host Cell By Promotion Of Host Phagocytosis ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Apoptotic Cell Clearance Negative Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Signal transduction by L1 Axon guidance Elastic fibre formation L1CAM interactions Non-integrin membrane-ECM interactions VEGFA-VEGFR2 Pathway Cell surface interactions at the vascular wall PECAM1 interactions Molecules associated with elastic fibres Syndecan interactions Laminin interactions Signaling by VEGF ECM proteoglycans Integrin cell surface interactions Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ITGA4 ITGAM ITGAV ITGB1 ITGB2 KRT31 NOTCH2NL RHAG	28 interactors: ADAM9 ANGPTL3 AUP1 AZGP1 CALR CD47 CYR61 EDIL3 F2R ICAM4 ITGB1 ITGB3 ITGB5 ITGB6 ITGB8 L1CAM MMP14 MMP2 NID1 NOV P2RY2 PAK4 PDGFRA PLP1 PTK2 SPP1 TGFB1 THY1
Entrez ID		3386	3685
HPRD ID		00198	01903
Ensembl ID		ENSG00000105371	ENSG00000138448
Uniprot IDs		Q14773	B7ZLX0 P06756
PDB IDs			1JV2 1L5G 1M1X 1U8C 3IJE 4G1E 4G1M
Enriched GO Terms of Interacting Partners?		Heterotypic Cell-cell Adhesion Cellular Extravasation Integrin-mediated Signaling Pathway Leukocyte Migration Extracellular Matrix Organization Extracellular Structure Organization Formation Of Primary Germ Layer Blood Coagulation Hemostasis Cell-matrix Adhesion Endodermal Cell Differentiation Single Organismal Cell-cell Adhesion Gastrulation Cell-substrate Adhesion Regulation Of Body Fluid Levels Wound Healing Endoderm Formation Response To Wounding Leukocyte Cell-cell Adhesion Endoderm Development Cell Migration Tissue Development Cell Motility Lymphocyte Activation Leukocyte Migration Involved In Inflammatory Response Leukocyte Tethering Or Rolling Developmental Process Cell Differentiation Leukocyte Activation Immune System Process Cell Adhesion Ameboidal-type Cell Migration Locomotion Activated T Cell Proliferation Chemotaxis Hemopoiesis Embryonic Morphogenesis Cell Activation Movement Of Cell Or Subcellular Component Immune System Development Viral Entry Into Host Cell Multicellular Organismal Development Entry Into Host Cell Substrate Adhesion-dependent Cell Spreading Neutrophil Chemotaxis Anatomical Structure Development Neutrophil Migration Regulation Of Immune Response Cell Surface Receptor Signaling Pathway Cell Development	Extracellular Matrix Organization Extracellular Structure Organization Cell Adhesion Integrin-mediated Signaling Pathway Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Cell Adhesion Positive Regulation Of Cell Motility Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Cell-matrix Adhesion Regulation Of Locomotion Regulation Of Cellular Component Movement Cell-substrate Adhesion Positive Regulation Of Cell Adhesion Locomotion Regulation Of Cell-substrate Adhesion Cardiovascular System Development Blood Vessel Development Response To External Stimulus Vasculature Development Single Organismal Cell-cell Adhesion Multicellular Organismal Development Cell Surface Receptor Signaling Pathway Developmental Process Blood Vessel Morphogenesis Cell Migration Tissue Development Cell Motility Angiogenesis Movement Of Cell Or Subcellular Component Positive Regulation Of Cell-substrate Adhesion Anatomical Structure Development Signaling Cell Communication Response To Stimulus Positive Regulation Of Cell Proliferation Signal Transduction Chemotaxis Wound Healing Organ Development Blood Coagulation Hemostasis System Development Cell-cell Adhesion Mediated By Integrin Single Organism Reproductive Process Response To Wounding Positive Regulation Of Kinase Activity Anatomical Structure Morphogenesis
Tagcloud ?		1beta activateds ccl20 ccl5 cl1 cldn1 csf2 cx cxcl1 cxcl10 cxcl11 cxcl3 cxcl5 cxcl6 granulocytes icam1 il23a il32 increaseds interleukins kappabeta laminin leucocyte metalloproteins mmp1 mmp3 msc survive trophic	bcl colorectal corresponding crc dissemination event extracellular ihc immunohistochemistry invasion ki matrix metastasis neoplastic overexpression perineural polymerase progression quantitative real regard resection sparc spread thbs1 underwent validation vcam vegf
Tagcloud (Difference) ?		1beta activateds ccl20 ccl5 cl1 cldn1 csf2 cx cxcl1 cxcl10 cxcl11 cxcl3 cxcl5 cxcl6 granulocytes icam1 il23a il32 increaseds interleukins kappabeta laminin leucocyte metalloproteins mmp1 mmp3 msc survive trophic	bcl colorectal corresponding crc dissemination event extracellular ihc immunohistochemistry invasion ki matrix metastasis neoplastic overexpression perineural polymerase progression quantitative real regard resection sparc spread thbs1 underwent validation vcam vegf
Tagcloud (Intersection) ?