ICAM4 and ITGB2

Number of citations of the paper that reports this interaction (PMID 10846180)
6

Data Source:
HPRD (in vivo)

		ICAM4	ITGB2
Gene Name		intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Plasma Membrane Integrin Complex Cell Surface Membrane Vesicle Integrin AlphaL-beta2 Complex Receptor Complex Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Integrin Binding	Glycoprotein Binding Protein Binding Protein Kinase Binding ICAM-3 Receptor Activity Protein Complex Binding Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding
	Biological Process	Cell Adhesion Single Organismal Cell-cell Adhesion Extracellular Matrix Organization Regulation Of Immune Response	Toll-like Receptor Signaling Pathway Leukocyte Migration Involved In Inflammatory Response Apoptotic Process Inflammatory Response Cell Adhesion Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell-cell Signaling Aging Blood Coagulation Regulation Of Cell Shape Natural Killer Cell Activation Extracellular Matrix Organization Neutrophil Chemotaxis Heterotypic Cell-cell Adhesion Toll-like Receptor 4 Signaling Pathway Endodermal Cell Differentiation Receptor Clustering Endothelial Cell Migration Innate Immune Response Cellular Extravasation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Activated T Cell Proliferation Leukocyte Migration Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Adaptive Immune System Innate Immune System
Drugs			Simvastatin
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ITGA4 ITGAM ITGAV ITGB1 ITGB2 KRT31 NOTCH2NL RHAG	41 interactors: CD14 CD226 CD82 COPS3 COPS5 CYTH1 CYTH2 DAB1 DOK1 ESM1 FCER2 FHL2 FUT4 GNB2L1 HP ICAM1 ICAM2 ICAM3 ICAM4 ICAM5 ILK ITGAD ITGAM ITGAX KNG1 NOTCH2NL NUMB PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRTN3 PTK2 PTK2B RANBP9 RDX SYK TLN1 VNN2
Entrez ID		3386	3689
HPRD ID		00198	02506
Ensembl ID		ENSG00000105371	ENSG00000160255
Uniprot IDs		Q14773	A8MYE6 P05107
PDB IDs			1JX3 1L3Y 1YUK 2JF1 2P26 2P28 2V7D 3K6S 3K71 3K72
Enriched GO Terms of Interacting Partners?		Heterotypic Cell-cell Adhesion Cellular Extravasation Integrin-mediated Signaling Pathway Leukocyte Migration Extracellular Matrix Organization Extracellular Structure Organization Formation Of Primary Germ Layer Blood Coagulation Hemostasis Cell-matrix Adhesion Endodermal Cell Differentiation Single Organismal Cell-cell Adhesion Gastrulation Cell-substrate Adhesion Regulation Of Body Fluid Levels Wound Healing Endoderm Formation Response To Wounding Leukocyte Cell-cell Adhesion Endoderm Development Cell Migration Tissue Development Cell Motility Lymphocyte Activation Leukocyte Migration Involved In Inflammatory Response Leukocyte Tethering Or Rolling Developmental Process Cell Differentiation Leukocyte Activation Immune System Process Cell Adhesion Ameboidal-type Cell Migration Locomotion Activated T Cell Proliferation Chemotaxis Hemopoiesis Embryonic Morphogenesis Cell Activation Movement Of Cell Or Subcellular Component Immune System Development Viral Entry Into Host Cell Multicellular Organismal Development Entry Into Host Cell Substrate Adhesion-dependent Cell Spreading Neutrophil Chemotaxis Anatomical Structure Development Neutrophil Migration Regulation Of Immune Response Cell Surface Receptor Signaling Pathway Cell Development	Blood Coagulation Hemostasis Platelet Activation Cell Activation Regulation Of Body Fluid Levels Wound Healing Response To Wounding Cell Adhesion Regulation Of Immune System Process Regulation Of Cell Adhesion Extracellular Matrix Organization Extracellular Structure Organization Single Organismal Cell-cell Adhesion Regulation Of Immune Response Positive Regulation Of Immune System Process Integrin-mediated Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Signal Transduction Regulation Of Catalytic Activity Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Signal Transduction Defense Response Signal Transduction Regulation Of Cellular Component Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Glial Cell Apoptotic Process Movement Of Cell Or Subcellular Component Locomotion Regulation Of Signaling Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To External Stimulus Cell Surface Receptor Signaling Pathway Signaling Positive Regulation Of Immune Response Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Immune System Process Positive Regulation Of Phosphorylation Leukocyte Activation Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Modification Process Activation Of Phospholipase C Activity
Tagcloud ?		1beta activateds ccl20 ccl5 cl1 cldn1 csf2 cx cxcl1 cxcl10 cxcl11 cxcl3 cxcl5 cxcl6 granulocytes icam1 il23a il32 increaseds interleukins kappabeta laminin leucocyte metalloproteins mmp1 mmp3 msc survive trophic	a2 caucasians cd8a concepts controversial encode highlighted hla icam il1b il2 itgal loadings meta mining modifier nonrandomly pooled ranked retrieved sell selp shared silico spite synapses text top truly
Tagcloud (Difference) ?		1beta activateds ccl20 ccl5 cl1 cldn1 csf2 cx cxcl1 cxcl10 cxcl11 cxcl3 cxcl5 cxcl6 granulocytes icam1 il23a il32 increaseds interleukins kappabeta laminin leucocyte metalloproteins mmp1 mmp3 msc survive trophic	a2 caucasians cd8a concepts controversial encode highlighted hla icam il1b il2 itgal loadings meta mining modifier nonrandomly pooled ranked retrieved sell selp shared silico spite synapses text top truly
Tagcloud (Intersection) ?