ICAM4 and ITGAM

Number of citations of the paper that reports this interaction (PMID 10846180)
6

Data Source:
HPRD (in vivo)

		ICAM4	ITGAM
Gene Name		intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	integrin, alpha M (complement component 3 receptor 3 subunit)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Nucleus Plasma Membrane Integrin Complex External Side Of Plasma Membrane Cell Surface Extracellular Vesicular Exosome
	Molecular Function	Integrin Binding	Opsonin Binding Glycoprotein Binding Protein Binding Heparin Binding Heparan Sulfate Proteoglycan Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Cell Adhesion Single Organismal Cell-cell Adhesion Extracellular Matrix Organization Regulation Of Immune Response	Toll-like Receptor Signaling Pathway Leukocyte Migration Involved In Inflammatory Response Cell Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Ectodermal Cell Differentiation Microglia Development Extracellular Matrix Organization Neutrophil Chemotaxis Toll-like Receptor 4 Signaling Pathway Innate Immune Response Cellular Extravasation Activated T Cell Proliferation Leukocyte Migration
Pathways		Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Integrin cell surface interactions Cell surface interactions at the vascular wall Innate Immune System
Drugs
Diseases
GWAS			Systemic lupus erythematosus ( 18204446 23273568 18204098 21408207 19165918) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Protein-Protein Interactions		8 interactors: ITGA4 ITGAM ITGAV ITGB1 ITGB2 KRT31 NOTCH2NL RHAG	18 interactors: AUP1 C3 CD209 CFH CLEC4M ELANE FGG GP1BA HP ICAM1 ICAM2 ICAM4 IRAK1 ITGB2 JAM3 PLAUR SHARPIN THY1
Entrez ID		3386	3684
HPRD ID		00198	00411
Ensembl ID		ENSG00000105371	ENSG00000169896
Uniprot IDs		Q14773	P11215
PDB IDs			1A8X 1BHO 1BHQ 1IDN 1IDO 1JLM 1M1U 1MF7 1N9Z 1NA5 2LKE 2LKJ 3Q3G 3QA3 4M76
Enriched GO Terms of Interacting Partners?		Heterotypic Cell-cell Adhesion Cellular Extravasation Integrin-mediated Signaling Pathway Leukocyte Migration Extracellular Matrix Organization Extracellular Structure Organization Formation Of Primary Germ Layer Blood Coagulation Hemostasis Cell-matrix Adhesion Endodermal Cell Differentiation Single Organismal Cell-cell Adhesion Gastrulation Cell-substrate Adhesion Regulation Of Body Fluid Levels Wound Healing Endoderm Formation Response To Wounding Leukocyte Cell-cell Adhesion Endoderm Development Cell Migration Tissue Development Cell Motility Lymphocyte Activation Leukocyte Migration Involved In Inflammatory Response Leukocyte Tethering Or Rolling Developmental Process Cell Differentiation Leukocyte Activation Immune System Process Cell Adhesion Ameboidal-type Cell Migration Locomotion Activated T Cell Proliferation Chemotaxis Hemopoiesis Embryonic Morphogenesis Cell Activation Movement Of Cell Or Subcellular Component Immune System Development Viral Entry Into Host Cell Multicellular Organismal Development Entry Into Host Cell Substrate Adhesion-dependent Cell Spreading Neutrophil Chemotaxis Anatomical Structure Development Neutrophil Migration Regulation Of Immune Response Cell Surface Receptor Signaling Pathway Cell Development	Single Organismal Cell-cell Adhesion Regulation Of Immune System Process Cell Adhesion Regulation Of Immune Response Extracellular Matrix Organization Extracellular Structure Organization Defense Response Virion Attachment To Host Cell Response To Stress Immune System Process Adhesion Of Symbiont To Host Immune Response Inflammatory Response Innate Immune Response Peptide Antigen Transport Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Cell-matrix Adhesion Blood Coagulation Hemostasis Cell-substrate Adhesion Leukocyte Migration Regulation Of Phosphorylation Acute Inflammatory Response To Antigenic Stimulus Acute Inflammatory Response Leukocyte Migration Involved In Inflammatory Response Complement Activation, Alternative Pathway Regulation Of Inflammatory Response Regulation Of Phosphorus Metabolic Process Regulation Of Body Fluid Levels Wound Healing Regulation Of Blood Coagulation Interaction With Host Regulation Of Protein Metabolic Process Leukocyte Cell-cell Adhesion Regulation Of Protein Phosphorylation Response To Stimulus Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Wounding Regulation Of Wound Healing Modulation By Virus Of Host Morphology Or Physiology Negative Regulation Of Endothelial Cell Apoptotic Process Viral Genome Replication Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Signal Transduction Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intracellular Transport Of Virus Positive Regulation Of Intracellular Signal Transduction Fibrinolysis Protein Activation Cascade
Tagcloud ?		1beta activateds ccl20 ccl5 cl1 cldn1 csf2 cx cxcl1 cxcl10 cxcl11 cxcl3 cxcl5 cxcl6 granulocytes icam1 il23a il32 increaseds interleukins kappabeta laminin leucocyte metalloproteins mmp1 mmp3 msc survive trophic	13qter 9p acp5 cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgbeta2 linkage mapping mu opioid oprm1 pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1
Tagcloud (Difference) ?		1beta activateds ccl20 ccl5 cl1 cldn1 csf2 cx cxcl1 cxcl10 cxcl11 cxcl3 cxcl5 cxcl6 granulocytes icam1 il23a il32 increaseds interleukins kappabeta laminin leucocyte metalloproteins mmp1 mmp3 msc survive trophic	13qter 9p acp5 cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgbeta2 linkage mapping mu opioid oprm1 pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1
Tagcloud (Intersection) ?