CD151 and MMP7

Number of citations of the paper that reports this interaction (PubMedID 16200075)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		CD151	MMP7
Description		CD151 molecule (Raph blood group)	matrix metallopeptidase 7
Image		No pdb structure
GO Annotations	Cellular Component	Basement Membrane Cytosol Plasma Membrane Focal Adhesion Cell Surface Membrane	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome
	Molecular Function	Integrin Binding Protein Binding	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Cell Adhesion Cell Migration Positive Regulation Of Cell Migration T Cell Proliferation Wound Healing, Spreading Of Cells Positive Regulation Of Endocytosis	Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Proteolysis Membrane Protein Ectodomain Proteolysis Response To Xenobiotic Stimulus Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Migration Collagen Catabolic Process Membrane Protein Intracellular Domain Proteolysis Regulation Of Cell Population Proliferation Defense Response To Bacterium Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium
Pathways		Assembly of collagen fibrils and other multimeric structures Type I hemidesmosome assembly	Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures Extra-nuclear estrogen signaling
Drugs			Marimastat (1R)-N,6-DIHYDROXY-7-METHOXY-2-[(4-METHOXYPHENYL)SULFONYL]-1,2,3,4-TETRAHYDROISOQUINOLINE-1-CARBOXAMIDE N4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDE 5-METHYL-3-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YLCARBAMOYL)-HEXANOIC ACID
Diseases		Nephropathy with pretibial epidermolysis bullosa and deafness
GWAS		Mean platelet volume ( 27863252 32888494) Platelet count ( 32888494)	Blood protein levels ( 30072576) Night sleep phenotypes ( 27126917) Prostate cancer ( 23535732) Prostate-specific antigen levels ( 28139693)
Interacting Genes		12 interacting genes: ARL13B BCL7A GRAMD1C ITGA3 ITGA6 ITGB1 KLRC1 MMP7 PTGFRN RNF128 TMEM139 TSPAN18	16 interacting genes: BCAN CD151 CD44 DCN FASLG HAPLN1 HBEGF MBP MMP1 MMP9 NGF PLG SERPINA1 SPP1 TFPI TNFSF11
Entrez ID		977	4316
HPRD ID		03763	01525
Ensembl ID		ENSG00000177697	ENSG00000137673
Uniprot IDs		P48509 Q6ZNZ0	P09237
PDB IDs			1MMP 1MMQ 1MMR 2DDY 2MZE 2MZH 2MZI 2Y6C 2Y6D 5UE2 5UE5 7WXX 8JUD 8JUF 8JUG 8K4Z
Enriched GO Terms of Interacting Partners?		Integrin Alpha6-beta1 Complex Integrin Alpha3-beta1 Complex Integrin Complex Formation Of Radial Glial Scaffolds Cell-matrix Adhesion Integrin-mediated Signaling Pathway Mesodermal Cell Differentiation Laminin Binding Negative Regulation Of Rho Protein Signal Transduction Cell-substrate Adhesion Myoblast Fusion Fibronectin Binding Receptor Complex Syncytium Formation By Plasma Membrane Fusion Cell-cell Fusion Syncytium Formation Positive Regulation Of Cell Migration Positive Regulation Of Locomotion Positive Regulation Of Cell Motility Integrin Alpha6-beta4 Complex Myoblast Fate Specification Integrin Alpha7-beta1 Complex Inhibitory MHC Class Ib Receptor Activity Antibacterial Peptide Secretion Signaling Receptor Activity Cell Surface Negative Regulation Of Small GTPase Mediated Signal Transduction Synaptic Membrane Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Periphery Neuromuscular Junction Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Integrin Alpha8-beta1 Complex Integrin Alpha1-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alphav-beta1 Complex Integrin Alpha11-beta1 Complex Cardiac Cell Fate Specification Integrin Alpha9-beta1 Complex HLA-E Specific Inhibitory MHC Class Ib Receptor Activity External Side Of Plasma Membrane Positive Regulation Of GTPase Activity Growth Cone Filopodium Regulation Of Rho Protein Signal Transduction Positive Regulation Of Protein Localization To Membrane Integrin Alpha4-beta1 Complex Integrin Alpha2-beta1 Complex Natural Killer Cell Inhibitory Signaling Pathway CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation	Extracellular Region Extracellular Space Extracellular Matrix Cell Surface Hyaluronic Acid Binding Wound Healing, Spreading Of Cells Extracellular Matrix Disassembly Regulation Of Response To Wounding Cellular Response To UV-A Perineuronal Net Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Lipid Transport Extracellular Matrix Structural Constituent Conferring Compression Resistance Positive Regulation Of Keratinocyte Migration Response To UV-A Positive Regulation Of Bone Resorption Lysosomal Lumen Positive Regulation Of Cell Communication Positive Regulation Of Signaling Endopeptidase Activity Regulation Of Cellular Component Organization Cell Migration Golgi Lumen Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Coagulation Blood Coagulation Protease Binding Peptidase Inhibitor Activity Hemostasis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Collateral Sprouting System Development Developmental Process Cell Motility Regulation Of Lipid Transport Regulation Of Wound Healing Positive Regulation Of Signal Transduction Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Tumor Necrosis Factor Receptor Binding Central Nervous System Development Extracellular Matrix Binding Serine-type Endopeptidase Activity Regulation Of Apoptotic Signaling Pathway Signaling Receptor Binding Positive Regulation Of ERBB Signaling Pathway Regulation Of Bone Resorption Collagen Catabolic Process
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