HSP90AA1 and USP50

Number of citations of the paper that reports this interaction (PMID 20930503)
6

Data Source:
BioGRID (two hybrid)

		HSP90AA1	USP50
Gene Name		heat shock protein 90kDa alpha (cytosolic), class A member 1	ubiquitin specific peptidase 50
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Melanosome Extracellular Vesicular Exosome Endocytic Vesicle Lumen
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ATPase Activity MHC Class II Protein Complex Binding Nitric-oxide Synthase Regulator Activity TPR Domain Binding Identical Protein Binding Protein Homodimerization Activity Poly(A) RNA Binding Unfolded Protein Binding	Ubiquitinyl Hydrolase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Mitochondrial Transport Receptor-mediated Endocytosis Response To Unfolded Protein Organelle Organization Signal Transduction Axon Guidance Cellular Response To Heat Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Protein Refolding Small Molecule Metabolic Process Protein Import Into Mitochondrial Outer Membrane Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Nitric Oxide Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Nitric-oxide Synthase Activity Chaperone-mediated Protein Complex Assembly Regulation Of Cellular Response To Heat	Ubiquitin-dependent Protein Catabolic Process
Pathways		HSF1 activation Regulatory RNA pathways Signaling by EGFRvIII in Cancer Regulation of PLK1 Activity at G2/M Transition Influenza Life Cycle Influenza Viral RNA Transcription and Replication Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Uptake and actions of bacterial toxins EPH-Ephrin signaling Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Fcgamma receptor (FCGR) dependent phagocytosis Recruitment of mitotic centrosome proteins and complexes Regulation of actin dynamics for phagocytic cup formation vRNP Assembly Influenza Infection Signaling by ERBB2 Signaling by VEGF Signaling by EGFR in Cancer Sema3A PAK dependent Axon repulsion Mitotic G2-G2/M phases Uptake and function of diphtheria toxin PIWI-interacting RNA (piRNA) biogenesis Organelle biogenesis and maintenance Axon guidance Attenuation phase G2/M Transition VEGFA-VEGFR2 Pathway HSF1-dependent transactivation EPHA-mediated growth cone collapse Metabolism of nitric oxide VEGFR2 mediated vascular permeability Loss of Nlp from mitotic centrosomes Scavenging by Class F Receptors eNOS activation and regulation Innate Immune System Semaphorin interactions Signaling by Ligand-Responsive EGFR Variants in Cancer Assembly of the primary cilium Cellular response to heat stress Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic eNOS activation Loss of proteins required for interphase microtubule organizationÂ from the centrosome Centrosome maturation Constitutive Signaling by EGFRvIII
Drugs		Rifabutin Nedocromil 9-Butyl-8-(2,5-Dimethoxy-Benzyl)-9h-Purin-6-Ylamine Geldanamycin 8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-2-Fluoro-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine 9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine 4-(1,3-Benzodioxol-5-Yl)-5-(5-Ethyl-2,4-Dihydroxyphenyl)-2h-Pyrazole-3-Carboxylic Acid 17-Dmag 8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-Ylamine 8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9-Pent-9h-Purin-6-Ylamine Adenosine-5\'-Diphosphate 9-Butyl-8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9h-Purin-6-Ylamine 4-(1h-Imidazol-4-Yl)-3-(5-Ethyl-2,4-Dihydroxy-Phenyl)-1h-Pyrazole 9-Butyl-8-(3-Methoxybenzyl)-9h-Purin-6-Amine 9-Butyl-8-(4-Methoxybenzyl)-9h-Purin-6-Amine 9-Butyl-8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-Ylamine 8-Benzo[1,3]Dioxol-,5-Ylmethyl-9-Butyl-2-Fluoro-9h-Purin-6-Ylamine 8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine N-[4-(AMINOSULFONYL)BENZYL]-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE N-(4-ACETYLPHENYL)-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE 4-CHLORO-6-(4-{4-[4-(METHYLSULFONYL)BENZYL]PIPERAZIN-1-YL}-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-PIPERAZIN-1-YL-1H-PYRAZOLE-3-CARBOXAMIDE 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]isoxazole-3-carboxamide 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)ISOXAZOLE-3-CARBOXAMIDE 2-amino-4-[2,4-dichloro-5-(2-pyrrolidin-1-ylethoxy)phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide 4-CHLORO-6-(4-PIPERAZIN-1-YL-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL (3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one 6-(3-BROMO-2-NAPHTHYL)-1,3,5-TRIAZINE-2,4-DIAMINE 3-({2-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)ETHYNYL]BENZYL}AMINO)-1,3-OXAZOL-2(3H)-ONE N-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)METHYL]-3-{[(E)-(2-OXODIHYDROFURAN-3(2H)-YLIDENE)METHYL]AMINO}BENZENESULFONAMIDE 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDE 4-bromo-6-(6-hydroxy-1,2-benzisoxazol-3-yl)benzene-1,3-diol 4-[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-METHYL-1H-PYRAZOL-5-YL]-6-ETHYLBENZENE-1,3-DIOL 4-chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diol 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE 4-methyl-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-amine (5E,7S)-2-amino-7-(4-fluoro-2-pyridin-3-ylphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one oxime 8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL-9H- 4-{[(2R)-2-(2-methylphenyl)pyrrolidin-1-yl]carbonyl}benzene-1,3-diol 2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol 2-[(2-methoxyethyl)amino]-4-(4-oxo-1,2,3,4-tetrahydro-9H-carbazol-9-yl)benzamide 4-(2-methoxyethoxy)-6-methylpyrimidin-2-amine 4-(2,4-dichlorophenyl)-5-phenyldiazenyl-pyrimidin-2-amine 3,6-DIAMINO-5-CYANO-4-(4-ETHOXYPHENYL)THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE 2-AMINO-4-(2,4-DICHLOROPHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE
Diseases
GWAS
Protein-Protein Interactions		130 interactors: AHR AHSA1 AHSA2 AIP AIPL1 AKT1 AKT2 APAF1 APOB AR ARNTL ASGR1 BIRC5 BRMS1 CALM1 CDC37 CDC37L1 CDK5R1 CDKN2A CERS2 CFTR CHEK1 CHUK CKS1B CKS2 CRNKL1 CSNK2A1 CSNK2A2 DAP3 DNAJC7 EIF2AK1 EIF2AK2 EIF2AK3 EPAS1 EPRS ERBB2 ERN1 ESR1 FAM162A FANCA FANCC FKBP4 FKBP5 FKBP6 FYN GNA12 GSK3B GUCY1B3 GZMA HDAC6 HIF1A HIF3A HSPA1A HSPA8 IKBKB IKBKE IKBKG IP6K2 IRAK1 IRF3 JUN KDR LCK LSM1 MAP3K14 MAP3K3 MAPK1 MCF2 MIS12 MMP2 MS4A2 MTRNR2L1 MYC MYOD1 NDRG1 NOS1 NOS3 NPAS2 NR2C2 NR3C1 NR3C2 NSL1 PAK1 PDPK1 PIM1 PMF1 PPARA PPARD PPID PPIL2 PPP5C PRKCA PRKCD PRKDC PTGDS PTGES3 RAF1 RIPK1 RPS3 RPS3A RUNX1T1 SGTA SIM1 SKP1 SLC2A4 SLC34A1 SMYD2 SMYD3 SNCA SRC ST13 STARD13 STAT3 STIP1 STUB1 SUGT1 SVIL TBK1 TERT TJP1 TNFRSF1A TOMM34 TOMM40 TOMM70A TP53 UBE2N UCHL1 USP19 USP50 WASL	2 interactors: HSP90AA1 HSP90AB1
Entrez ID		3320	373509
HPRD ID		00777	15639
Ensembl ID		ENSG00000080824	ENSG00000170236
Uniprot IDs		K9JA46 P07900 Q86SX1	E9PP86 Q70EL3
PDB IDs		1BYQ 1OSF 1UY6 1UY7 1UY8 1UY9 1UYC 1UYD 1UYE 1UYF 1UYG 1UYH 1UYI 1UYK 1UYL 1YC1 1YC3 1YC4 1YER 1YES 1YET 2BSM 2BT0 2BUG 2BYH 2BYI 2BZ5 2C2L 2CCS 2CCT 2CCU 2CDD 2FWY 2FWZ 2H55 2JJC 2K5B 2QF6 2QFO 2QG0 2QG2 2UWD 2VCI 2VCJ 2WI1 2WI2 2WI3 2WI4 2WI5 2WI6 2WI7 2XAB 2XDK 2XDL 2XDS 2XDU 2XDX 2XHR 2XHT 2XHX 2XJG 2XJJ 2XJX 2XK2 2YE2 2YE3 2YE4 2YE5 2YE6 2YE7 2YE8 2YE9 2YEA 2YEB 2YEC 2YED 2YEE 2YEF 2YEG 2YEH 2YEI 2YEJ 2YI0 2YI5 2YI6 2YI7 2YJW 2YJX 2YK2 2YK9 2YKB 2YKC 2YKE 2YKI 2YKJ 3B24 3B25 3B26 3B27 3B28 3BM9 3BMY 3D0B 3EKO 3EKR 3FT5 3FT8 3HEK 3HHU 3HYY 3HYZ 3HZ1 3HZ5 3INW 3INX 3K97 3K98 3K99 3MNR 3O0I 3OW6 3OWB 3OWD 3Q6M 3Q6N 3QDD 3QTF 3R4M 3R4N 3R4O 3R4P 3R91 3R92 3RKZ 3RLP 3RLQ 3RLR 3T0H 3T0Z 3T10 3T1K 3T2S 3TUH 3VHA 3VHC 3VHD 4AIF 4AWO 4AWP 4AWQ 4B7P 4EEH 4EFT 4EFU 4EGH 4EGI 4EGK 4FCP 4FCQ 4FCR 4HY6 4JQL
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Response To Organic Substance Cellular Response To Stimulus Response To Stress Regulation Of Cell Death Response To Organic Substance Response To Stimulus Positive Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Apoptotic Process Programmed Cell Death Regulation Of Metabolic Process Response To Abiotic Stimulus Cellular Metabolic Process Regulation Of Apoptotic Process Cell Death Positive Regulation Of Signal Transduction Death Regulation Of Signaling Cellular Response To Stress Cell Communication Positive Regulation Of Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Catalytic Activity Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Signal Transduction Signaling Positive Regulation Of Catalytic Activity Regulation Of Phosphorylation Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Death Regulation Of Gene Expression Response To External Stimulus Innate Immune Response Positive Regulation Of Cellular Biosynthetic Process Response To Growth Factor Phosphorylation Cellular Response To Growth Factor Stimulus Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Phosphorylation Negative Regulation Of Programmed Cell Death Negative Regulation Of Cellular Metabolic Process	Regulation Of Cellular Response To Heat Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Heat Positive Regulation Of Reactive Oxygen Species Metabolic Process Response To Heat Response To Unfolded Protein Regulation Of Reactive Oxygen Species Metabolic Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Response To Temperature Stimulus Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Folding Immune Response-regulating Cell Surface Receptor Signaling Pathway Axon Guidance Protein Import Into Mitochondrial Outer Membrane Immune Response-regulating Signaling Pathway Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Positive Regulation Of Immune Response Neuron Projection Morphogenesis Endocytosis Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Import Into Nucleus, Translocation Chaperone-mediated Protein Complex Assembly Innate Immune Response Neuron Projection Development Cell Projection Morphogenesis Positive Regulation Of Cell Size Cell Part Morphogenesis Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Protein Import Into Nucleus, Translocation Protein Refolding Neuron Development Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Cell Morphogenesis Response To Abiotic Stimulus Neuron Differentiation Nitric Oxide Metabolic Process Cell Projection Organization Reactive Nitrogen Species Metabolic Process
Tagcloud ?		alphascreen ammp calnexin cndp2 combines hspa5 hspa9 identifier imbalance itraq nfhcc nonfibrotic nontumor p4hb pdia6 phosphoproteomics pointed proteomexchange proteomics proteostasis pxd001253 resident ser583 txn ubc unraveling vcp
Tagcloud (Difference) ?		alphascreen ammp calnexin cndp2 combines hspa5 hspa9 identifier imbalance itraq nfhcc nonfibrotic nontumor p4hb pdia6 phosphoproteomics pointed proteomexchange proteomics proteostasis pxd001253 resident ser583 txn ubc unraveling vcp
Tagcloud (Intersection) ?