HSP90AA1 and PPID

Number of citations: 0 (PubMedID 12145316)
Data Source: HPRD (in vitro, two hybrid)

		HSP90AA1	PPID
Name		heat shock protein 90 alpha family class A member 1	peptidylprolyl isomerase D
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Brush Border Membrane Protein-containing Complex Secretory Granule Lumen Sperm Flagellum Melanosome Neuronal Cell Body Lysosomal Lumen Myelin Sheath Dendritic Growth Cone Axonal Growth Cone Perinuclear Region Of Cytoplasm Extracellular Exosome Endocytic Vesicle Lumen Sperm Mitochondrial Sheath Sperm Plasma Membrane Protein Folding Chaperone Complex Ficolin-1-rich Granule Lumen	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cilium
	Molecular Function	Nucleotide Binding UTP Binding CTP Binding RNA Binding MRNA Binding Protein Binding ATP Binding GTP Binding Hydrolase Activity ATP Hydrolysis Activity Sulfonylurea Receptor Binding Protein Phosphatase Binding MHC Class II Protein Complex Binding Nitric-oxide Synthase Regulator Activity TPR Domain Binding Ubiquitin Protein Ligase Binding DATP Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Protein Folding Chaperone Transmembrane Transporter Binding Tau Protein Binding GTPase Binding Rho GDP-dissociation Inhibitor Binding Unfolded Protein Binding DNA Polymerase Binding Scaffold Protein Binding Disordered Domain Specific Binding ATP-dependent Protein Folding Chaperone Enzyme-substrate Adaptor Activity Protein Tyrosine Kinase Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Transcription Factor Binding Cyclosporin A Binding Isomerase Activity Nuclear Estrogen Receptor Binding Hsp70 Protein Binding Heat Shock Protein Binding Hsp90 Protein Binding
	Biological Process	Neuron Migration Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Skeletal Muscle Contraction Protein Folding Mitochondrial Transport Response To Unfolded Protein Telomere Maintenance Via Telomerase Response To Heat Response To Cold Response To Xenobiotic Stimulus Response To Salt Stress Positive Regulation Of Lamellipodium Assembly Cardiac Muscle Cell Apoptotic Process Protein Import Into Mitochondrial Matrix Regulation Of Protein Ubiquitination Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Protein Polymerization Positive Regulation Of Interferon-beta Production Regulation Of Protein Localization Cellular Response To Heat Protein Refolding Response To Cocaine Positive Regulation Of Protein Import Into Nucleus Regulation Of Apoptotic Process Regulation Of Protein-containing Complex Assembly Protein Unfolding Response To Estrogen Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Size Nitric Oxide Metabolic Process Response To Antibiotic Protein Stabilization Chaperone-mediated Protein Complex Assembly Positive Regulation Of Cardiac Muscle Contraction Chaperone-mediated Autophagy Cellular Response To Virus Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Neurofibrillary Tangle Assembly Telomerase Holoenzyme Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Protein Folding Apoptotic Process Protein Transport Viral Release From Host Cell Lipid Droplet Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Viral Genome Replication Positive Regulation Of Protein Secretion Protein-containing Complex Assembly Cellular Response To UV-A
Pathways		Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation DDX58/IFIH1-mediated induction of interferon-alpha/beta vRNP Assembly Regulation of actin dynamics for phagocytic cup formation eNOS activation Regulation of PLK1 Activity at G2/M Transition Scavenging by Class F Receptors Scavenging by Class F Receptors HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand HSF1 activation Attenuation phase HSF1-dependent transactivation Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Sema3A PAK dependent Axon repulsion VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway VEGFR2 mediated vascular permeability Uptake and function of diphtheria toxin PIWI-interacting RNA (piRNA) biogenesis Anchoring of the basal body to the plasma membrane Constitutive Signaling by EGFRvIII Regulation of necroptotic cell death Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Downregulation of ERBB2 signaling ESR-mediated signaling Extra-nuclear estrogen signaling RHOBTB2 GTPase cycle Estrogen-dependent gene expression Chaperone Mediated Autophagy Constitutive Signaling by Overexpressed ERBB2 Aggrephagy Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants Potential therapeutics for SARS SARS-CoV-2 activates/modulates innate and adaptive immune responses Assembly and release of respiratory syncytial virus (RSV) virions Respiratory syncytial virus genome replication	ESR-mediated signaling
Drugs		Rifabutin Nedocromil 9-Butyl-8-(2,5-Dimethoxy-Benzyl)-9h-Purin-6-Ylamine Geldanamycin 8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-2-Fluoro-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine 9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine 4-(1,3-Benzodioxol-5-Yl)-5-(5-Ethyl-2,4-Dihydroxyphenyl)-2h-Pyrazole-3-Carboxylic Acid 8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-Ylamine 8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9-Pent-9h-Purin-6-Ylamine 9-Butyl-8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9h-Purin-6-Ylamine 4-(1h-Imidazol-4-Yl)-3-(5-Ethyl-2,4-Dihydroxy-Phenyl)-1h-Pyrazole 9-Butyl-8-(3-Methoxybenzyl)-9h-Purin-6-Amine 9-Butyl-8-(4-Methoxybenzyl)-9h-Purin-6-Amine 9-Butyl-8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-Ylamine Quercetin 8-Benzo[1,3]Dioxol-,5-Ylmethyl-9-Butyl-2-Fluoro-9h-Purin-6-Ylamine 8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine N-[4-(AMINOSULFONYL)BENZYL]-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE Tanespimycin SNX-5422 N-(4-ACETYLPHENYL)-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE 4-CHLORO-6-(4-{4-[4-(METHYLSULFONYL)BENZYL]PIPERAZIN-1-YL}-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-PIPERAZIN-1-YL-1H-PYRAZOLE-3-CARBOXAMIDE 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]isoxazole-3-carboxamide 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)ISOXAZOLE-3-CARBOXAMIDE 2-amino-4-[2,4-dichloro-5-(2-pyrrolidin-1-ylethoxy)phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide 4-CHLORO-6-(4-PIPERAZIN-1-YL-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL (3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one 6-(3-BROMO-2-NAPHTHYL)-1,3,5-TRIAZINE-2,4-DIAMINE 3-({2-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)ETHYNYL]BENZYL}AMINO)-1,3-OXAZOL-2(3H)-ONE N-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)METHYL]-3-{[(E)-(2-OXODIHYDROFURAN-3(2H)-YLIDENE)METHYL]AMINO}BENZENESULFONAMIDE 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDE 4-bromo-6-(6-hydroxy-1,2-benzisoxazol-3-yl)benzene-1,3-diol CCT-018159 4-chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diol 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE 4-methyl-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-amine (5E,7S)-2-amino-7-(4-fluoro-2-pyridin-3-ylphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one oxime 8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL-9H- 4-{[(2R)-2-(2-methylphenyl)pyrrolidin-1-yl]carbonyl}benzene-1,3-diol 2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol 2-[(2-methoxyethyl)amino]-4-(4-oxo-1,2,3,4-tetrahydro-9H-carbazol-9-yl)benzamide 4-(2-methoxyethoxy)-6-methylpyrimidin-2-amine 4-(2,4-dichlorophenyl)-5-phenyldiazenyl-pyrimidin-2-amine 3,6-DIAMINO-5-CYANO-4-(4-ETHOXYPHENYL)THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE 2-AMINO-4-(2,4-DICHLOROPHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE Copper Polaprezinc Alvespimycin	None
GWAS		Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143 )	Blood protein levels ( 30072576 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Serum metabolite levels ( 23093944 )
Interacting Genes		196 interacting genes: A1BG A2M AGT AHR AHSA1 AHSA2P AHSG AIP AIPL1 AKT1 AKT2 APAF1 APOA1 APOA4 APOB APOE AR ASGR1 BIRC5 BMAL1 BRMS1 BTG3 C3 C4A C4BPA CACYBP CALM1 CDC37 CDC37L1 CDK5R1 CDKN2A CERS2 CFB CFTR CHEK1 CHORDC1 CHUK CKS1B CKS2 COL12A1 CP CRNKL1 CSNK2A1 CSNK2A2 DAP3 DCD DNAJC7 EGFR EGLN1 EIF2AK1 EIF2AK2 EIF2AK3 EIF2S1 EPRS1 ERBB2 ERN1 ESR1 ESRRB FAM162A FANCC FASN FGA FKBP1A FKBP5 FKBP6 FLCN FLG2 FN1 FNIP1 FYN GC GNA12 GSK3A GSN GUCY1B1 GZMA HECTD3 HIF1A HIF3A HP HPR HPX HRNR HSF1 HSPA8 HSPG2 HTT IKBKB IKBKE IKBKG IP6K2 IRAK1 IRF3 ITGB1BP2 ITIH1 JUN JUP KDR KEAP1 LCK LGALS3BP LINC01554 LOXL2 LRP1 LSM1 MAP3K14 MAP3K3 MAPK1 MMP2 MS4A2 MTRNR2L1 MUC1 MYC MYOD1 NDRG1 NOS1 NOS3 NPAS2 NR2C2 NR3C1 NR3C2 NSL1 PABPN1 PAK1 PDPK1 PIM1 PKM PLG PMF1 PPARA PPARD PPID PPIL2 PPP5C PRKCA PRKCD PRKDC PTGDS PTGES3 PTP4A2 PTPRF RAD51 RAF1 RHOBTB2 RIPK1 RIPPLY3 RPAP3 RPS3 RPS3A RUNX1T1 SERPINA1 SERPINA3 SERPINB5 SERPINC1 SERPING1 SGTA SHKBP1 SIM1 SKP1 SLC2A4 SLC34A1 SMYD2 SMYD3 SRC ST13 STARD13 STAT3 STIP1 STUB1 SUGT1 SUMO2 SVIL TBK1 TERT TF THBS1 TJP1 TLN1 TNFRSF1A TOMM34 TOMM40 TOMM70 TP53 TTK TTR UBASH3A UBE2N UCHL1 UNC45A USP19 USP50 WASL WEE2-AS1 YWHAE YWHAZ ZBTB7A	20 interacting genes: APP BCL2 CSNK2B ESR1 FBXO25 FES HAP1 HSF1 HSP90AA1 HSP90AB1 HSPA8 KAT7 LNX1 PLK1 S100A1 S100A2 S100A6 SLC25A4 SMURF2 TRIM27
Entrez ID		3320	5481
HPRD ID		00777	11875
Ensembl ID		ENSG00000080824	ENSG00000171497
Uniprot IDs		K9JA46 P07900 Q86SX1	E5KN55 Q08752
PDB IDs		1BYQ 1OSF 1UY6 1UY7 1UY8 1UY9 1UYC 1UYD 1UYE 1UYF 1UYG 1UYH 1UYI 1UYK 1UYL 1YC1 1YC3 1YC4 1YER 1YES 1YET 2BSM 2BT0 2BUG 2BYH 2BYI 2BZ5 2C2L 2CCS 2CCT 2CCU 2FWY 2FWZ 2H55 2JJC 2K5B 2QF6 2QFO 2QG0 2QG2 2UWD 2VCI 2VCJ 2WI1 2WI2 2WI3 2WI4 2WI5 2WI6 2WI7 2XAB 2XDK 2XDL 2XDS 2XDU 2XDX 2XHR 2XHT 2XHX 2XJG 2XJJ 2XJX 2XK2 2YE2 2YE3 2YE4 2YE5 2YE6 2YE7 2YE8 2YE9 2YEA 2YEB 2YEC 2YED 2YEE 2YEF 2YEG 2YEH 2YEI 2YEJ 2YI0 2YI5 2YI6 2YI7 2YJW 2YJX 2YK2 2YK9 2YKB 2YKC 2YKE 2YKI 2YKJ 3B24 3B25 3B26 3B27 3B28 3BM9 3BMY 3D0B 3EKO 3EKR 3FT5 3FT8 3HEK 3HHU 3HYY 3HYZ 3HZ1 3HZ5 3INW 3INX 3K97 3K98 3K99 3MNR 3O0I 3OW6 3OWB 3OWD 3Q6M 3Q6N 3QDD 3QTF 3R4M 3R4N 3R4O 3R4P 3R91 3R92 3RKZ 3RLP 3RLQ 3RLR 3T0H 3T0Z 3T10 3T1K 3T2S 3TUH 3VHA 3VHC 3VHD 3WHA 3WQ9 4AIF 4AWO 4AWP 4AWQ 4B7P 4BQG 4BQJ 4CGQ 4CGU 4CGV 4CGW 4CWF 4CWN 4CWO 4CWP 4CWQ 4CWR 4CWS 4CWT 4EEH 4EFT 4EFU 4EGH 4EGI 4EGK 4FCP 4FCQ 4FCR 4HY6 4JQL 4L8Z 4L90 4L91 4L93 4L94 4LWE 4LWF 4LWG 4LWH 4LWI 4NH7 4NH8 4O04 4O05 4O07 4O09 4O0B 4R3M 4U93 4W7T 4XIP 4XIQ 4XIR 4XIT 4YKQ 4YKR 4YKT 4YKU 4YKW 4YKX 4YKY 4YKZ 5CF0 5FNC 5FND 5FNF 5GGZ 5J20 5J27 5J2V 5J2X 5J64 5J6L 5J6M 5J6N 5J80 5J82 5J86 5J8M 5J8U 5J9X 5LNY 5LNZ 5LO0 5LO1 5LO5 5LO6 5LQ9 5LR1 5LR7 5LRL 5LRZ 5LS1 5M4E 5M4H 5NYH 5NYI 5OCI 5OD7 5ODX 5T21 5VYY 5XQD 5XQE 5XR5 5XR9 5XRB 5XRD 5XRE 5ZR3 6B99 6B9A 6CEO 6CYG 6CYH 6EI5 6EL5 6ELN 6ELO 6ELP 6EY8 6EY9 6EYA 6EYB 6F1N 6FCJ 6FDP 6GP4 6GP8 6GPF 6GPH 6GPO 6GPP 6GPR 6GPT 6GPW 6GPY 6GQ6 6GQR 6GQS 6GQU 6GR1 6GR3 6GR4 6GR5 6HHR 6KSQ 6LR9 6LSZ 6LT8 6LTI 6LTK 6N8X 6OLX 6TN4 6TN5 6U98 6U99 6U9A 6U9B 7DMC 7KRJ 7KW7 7L7I 7L7J 7LSZ 7LT0 7RXZ 7RY0 7RY1 7S8Y 7S8Z 7S90 7S95 7S98 7S99 7S9F 7S9G 7S9H 7S9I 7UR3 8AGI 8AGJ 8AGL 8B7I 8B7J 8FFV 8FFW 8JR6 8JR7 8JRA 8KI4 8SBT 8W4V 8W8K 8X2R 9AUU	Not available
GO Terms Enriched among Interactors		Hsp90 Protein Binding Blood Microparticle Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Intracellular Signal Transduction Response To Stress Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cell Communication Intracellular Signaling Cassette Positive Regulation Of Signaling Cellular Response To Stress Regulation Of Signaling Regulation Of Cell Communication Cytosol Protein Metabolic Process Enzyme Binding Protein Kinase Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Regulation Of Primary Metabolic Process Signal Transduction Kinase Activity Positive Regulation Of Metabolic Process Negative Regulation Of Apoptotic Process Regulation Of Metabolic Process Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Stability Programmed Cell Death Cytoplasm Cell Death Negative Regulation Of Programmed Cell Death Heat Shock Protein Binding Cellular Response To Oxygen-containing Compound Extracellular Exosome Positive Regulation Of Apoptotic Process Apoptotic Process Negative Regulation Of Signal Transduction Response To Hormone Protein-folding Chaperone Binding Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Protein-containing Complex Regulation Of Cellular Response To Stress Response To Oxygen Levels Protein Serine/threonine Kinase Activity	Identical Protein Binding Positive Regulation Of Nitric Oxide Biosynthetic Process Nitric-oxide Synthase Regulator Activity Protein Folding Chaperone Complex Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Catabolic Process Negative Regulation Of Metabolic Process Cytoplasm Response To Unfolded Protein Regulation Of Protein Import Cytosol MHC Class II Protein Complex Binding Protein Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process ATP-dependent Protein Folding Chaperone Positive Regulation Of Developmental Process Secretory Granule Lumen Ficolin-1-rich Granule Lumen Negative Regulation Of RNA Metabolic Process Regulation Of Viral Process Telomerase Holoenzyme Complex Assembly Protein-containing Complex Chaperone-mediated Autophagy Cellular Response To Heat Regulation Of Protein Localization To Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Dendritic Growth Cone TPR Domain Binding Regulation Of Cellular Component Organization Protein Folding Chaperone Positive Regulation Of Cell Differentiation Regulation Of Primary Metabolic Process Protein Modification Process Heat Shock Protein Binding Regulation Of Multicellular Organism Growth Regulation Of Protein Catabolic Process Regulation Of Protein Localization Regulation Of Protein Stability Protein Ubiquitination Regulation Of Biological Quality Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Catabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Calcium-dependent Protein Binding Regulation Of Metabolic Process