INSR and SYNCRIP

Number of citations of the paper that reports this interaction (PMID 11994298)
11

Data Source:
HPRD (in vitro)

		INSR	SYNCRIP
Gene Name		insulin receptor	synaptotagmin binding, cytoplasmic RNA interacting protein
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Insulin Receptor Complex Caveola Endosome Membrane Membrane Intracellular Membrane-bounded Organelle Receptor Complex Extracellular Vesicular Exosome	Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Ribonucleoprotein Complex CRD-mediated MRNA Stability Complex Catalytic Step 2 Spliceosome Histone Pre-mRNA 3'end Processing Complex GAIT Complex
	Molecular Function	Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Insulin-activated Receptor Activity Insulin-like Growth Factor Receptor Binding Protein Binding ATP Binding GTP Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Phosphatidylinositol 3-kinase Binding Insulin Binding Insulin Receptor Substrate Binding PTB Domain Binding	Nucleotide Binding RNA Binding Protein Binding Poly(A) Binding Poly(A) RNA Binding
	Biological Process	Activation Of MAPK Activity Positive Regulation Of Protein Phosphorylation Heart Morphogenesis Carbohydrate Metabolic Process Regulation Of Transcription, DNA-templated G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Epidermis Development Peptidyl-tyrosine Phosphorylation Transformation Of Host Cell By Virus Signal Transduction By Phosphorylation Male Sex Determination Positive Regulation Of Cell Migration Exocrine Pancreas Development Activation Of Protein Kinase Activity Activation Of Protein Kinase B Activity Cellular Response To Insulin Stimulus Peptidyl-tyrosine Autophosphorylation Glucose Homeostasis Positive Regulation Of MAPK Cascade Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of DNA Replication Positive Regulation Of Glycolytic Process Positive Regulation Of Mitotic Nuclear Division Regulation Of Embryonic Development Positive Regulation Of Glucose Import Protein Autophosphorylation Positive Regulation Of Developmental Growth Protein Heterotetramerization Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Respiratory Burst Cellular Response To Growth Factor Stimulus	MRNA Splicing, Via Spliceosome Osteoblast Differentiation RNA Processing RNA Splicing Viral Process Negative Regulation Of Translation CRD-mediated MRNA Stabilization Cellular Response To Interferon-gamma
Pathways		Insulin receptor signalling cascade IRS activation Signal attenuation IRS-related events SHC-related events Insulin receptor recycling SHC activation Signaling by Insulin receptor
Drugs		Insulin Regular Insulin Lispro Insulin Glargine Insulin, porcine Mecasermin Insulin Aspart Insulin Detemir Insulin Glulisine Adenosine-5\'-[Beta, Gamma-Methylene]Triphosphate [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID Insulin, isophane
Diseases
GWAS		Diabetic retinopathy ( 21441570) Height ( 20881960) Hypothyroidism ( 22493691) Polycystic ovary syndrome ( 22885925) Thyroid hormone levels ( 23408906) Urate levels ( 23263486)
Protein-Protein Interactions		77 interactors: ACP1 ADRB2 AHSG ARF1 ARHGAP26 CALM1 CALM2 CALM3 CAV1 CAV3 CBL CEACAM1 CRK CRKL CSK DOK1 DOK4 DOK5 ENPP1 FABP4 FRS2 GAB1 GNB2L1 GRB10 GRB14 GRB7 HRAS IGF1R IGF2 INS INSRR IRF7 IRS1 IRS2 JAK1 JAK2 KHDRBS1 KRT27 KRT31 MAD2L1 MAPK3 PIK3R1 PIK3R3 PLCG1 PRKCA PRKCD PTK2 PTPN1 PTPN11 PTPN12 PTPN2 PTPN6 PTPRC PTPRF RAF1 RASA1 SH2B1 SH2B2 SHC1 SMAD2 SNX1 SNX2 SNX4 SNX6 SOCS1 SOCS2 SOCS3 SOCS6 SORBS1 SRC STAT5A STAT5B SYNCRIP TEAD1 VAV1 VAV3 YWHAB	31 interactors: A1CF APOBEC1 APP CSDE1 EPRS GRB2 HABP4 HMGA1 HMGA2 HNRNPD HNRNPK IL7R INSR IVNS1ABP KLHL3 NUPR1 PABPC1 PCSK7 PLCG1 PRMT1 PRMT8 PTPN11 SMN1 SYT1 SYT11 SYT2 SYT3 SYT4 SYT7 SYT8 SYT9
Entrez ID		3643	10492
HPRD ID		00975	06734
Ensembl ID		ENSG00000171105	ENSG00000135316
Uniprot IDs		P06213	B7Z645 O60506 Q59GL1
PDB IDs		1GAG 1I44 1IR3 1IRK 1P14 1RQQ 2AUH 2B4S 2DTG 2HR7 2Z8C 3BU3 3BU5 3BU6 3EKK 3EKN 3ETA 3LOH 3W11 3W12 3W13 3W14 4IBM	2DGU
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Kinase Activity Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Cellular Response To Hormone Stimulus Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Protein Kinase Activity Cellular Response To Organic Substance Response To Organonitrogen Compound Regulation Of Signal Transduction Insulin Receptor Signaling Pathway Response To Hormone Cellular Response To Insulin Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Protein Phosphorylation Intracellular Signal Transduction Blood Coagulation Hemostasis Response To Insulin Response To Organic Substance Regulation Of Body Fluid Levels Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Wound Healing Signal Transduction Immune System Process Neurotrophin TRK Receptor Signaling Pathway Innate Immune Response Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Neurotrophin Signaling Pathway Growth Hormone Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Wounding Defense Response Signaling Immune Response-regulating Signaling Pathway	Exocytosis MRNA Metabolic Process RNA Processing Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis MRNA Processing Cytidine To Uridine Editing Oncogene-induced Cell Senescence Secretion By Cell Positive Regulation Of Transport Senescence-associated Heterochromatin Focus Assembly Regulation Of Vesicle-mediated Transport Positive Regulation Of Cellular Senescence Regulation Of Vesicle Fusion Secretion Regulation Of Secretion RNA Metabolic Process Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Negative Regulation Of Chromatin Silencing Base Conversion Or Substitution Editing Regulation Of Cellular Localization Regulation Of Exocytosis Positive Regulation Of Cellular Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Positive Regulation Of Cell Aging Vesicle-mediated Transport Viral Process Positive Regulation Of Exocytosis RNA Splicing Regulation Of Growth Hormone Secretion Wound Healing Regulation Of Gene Expression Heterochromatin Assembly Positive Regulation Of Protein Metabolic Process Peptidyl-arginine N-methylation Histone H4-R3 Methylation Positive Regulation Of Metabolic Process Cellular Response To Insulin Stimulus Gene Expression Regulation Of Peptide Hormone Secretion Heterochromatin Organization Blood Coagulation Reproductive Process Hemostasis MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Response To Wounding
Tagcloud ?		birthweight cognate curly delays determinant dwarfing edema eliminated embryogenesis embryos epidermis generalized hypoplasia igf1r igf2 igr1r indistinguishable manifested mildly muscles nullizygotes nullizygous ossification phenotypically recognizes retardation solely thin xr	autonomy back bmp bottom connections correct explained genetically glass highlight influences maintaining modulates morphogenic motoneuron output partly plasticity postsynaptic presynaptic probability proper retrograde signals synapse synaptic transmission unexpected vesicle
Tagcloud (Difference) ?		birthweight cognate curly delays determinant dwarfing edema eliminated embryogenesis embryos epidermis generalized hypoplasia igf1r igf2 igr1r indistinguishable manifested mildly muscles nullizygotes nullizygous ossification phenotypically recognizes retardation solely thin xr	autonomy back bmp bottom connections correct explained genetically glass highlight influences maintaining modulates morphogenic motoneuron output partly plasticity postsynaptic presynaptic probability proper retrograde signals synapse synaptic transmission unexpected vesicle
Tagcloud (Intersection) ?