INSR and FABP4

Number of citations of the paper that reports this interaction (PubMedID 1648089)
0

Data Source:
HPRD (in vitro, in vivo)

		INSR	FABP4
Description		insulin receptor	fatty acid binding protein 4
Image
GO Annotations	Cellular Component	Nuclear Envelope Lysosome Endosome Late Endosome Plasma Membrane Insulin Receptor Complex Caveola External Side Of Plasma Membrane Endosome Membrane Membrane Axon Dendrite Nuclear Lumen Dendrite Membrane Neuronal Cell Body Membrane Neuronal Cell Body Receptor Complex Cell Body Extracellular Exosome	Nucleus Cytoplasm Lipid Droplet Cytosol Extracellular Exosome
	Molecular Function	Nucleotide Binding Amyloid-beta Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Insulin Receptor Activity Insulin-like Growth Factor Receptor Binding Structural Molecule Activity Protein Binding ATP Binding GTP Binding Kinase Activity Transferase Activity Protein Domain Specific Binding Protein Kinase Activator Activity Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Cargo Receptor Activity Identical Protein Binding Phosphatidylinositol 3-kinase Binding Insulin Binding Insulin Receptor Substrate Binding Protein-containing Complex Binding PTB Domain Binding	Long-chain Fatty Acid Transmembrane Transporter Activity Fatty Acid Binding Lipid Binding Long-chain Fatty Acid Binding Hormone Receptor Binding
	Biological Process	Positive Regulation Of Receptor Internalization Heart Morphogenesis Regulation Of Glycogen Biosynthetic Process Regulation Of DNA-templated Transcription Receptor-mediated Endocytosis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Learning Memory Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Epidermis Development Male Gonad Development Animal Organ Morphogenesis Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Glucose Metabolic Process Male Sex Determination Adrenal Gland Development Positive Regulation Of Cell Migration Exocrine Pancreas Development Receptor Internalization Cellular Response To Insulin Stimulus Glucose Homeostasis Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein-containing Complex Disassembly Positive Regulation Of MAPK Cascade Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Positive Regulation Of D-glucose Import Symbiont Entry Into Host Cell Protein Autophosphorylation Animal Organ Development Positive Regulation Of Developmental Growth System Development Positive Regulation Of Cellular Component Organization Regulation Of Multicellular Organismal Process Positive Regulation Of Meiotic Cell Cycle Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Respiratory Burst Cellular Response To Growth Factor Stimulus Dendritic Spine Maintenance Amyloid-beta Clearance Transport Across Blood-brain Barrier Neuron Projection Maintenance Regulation Of Female Gonad Development	Response To Bacterium Fatty Acid Transport Long-chain Fatty Acid Transport Cholesterol Homeostasis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Inflammatory Response White Fat Cell Differentiation Brown Fat Cell Differentiation Cellular Response To Lithium Ion Cellular Response To Tumor Necrosis Factor Positive Regulation Of Cold-induced Thermogenesis
Pathways		PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation Insulin receptor signalling cascade Signaling by Insulin receptor Insulin receptor recycling	Triglyceride catabolism Triglyceride catabolism Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs		Insulin human Insulin lispro Insulin glargine Insulin pork Mecasermin Insulin aspart Insulin detemir Insulin glulisine Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate NN344 AT1391 Linsitinib [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID Chromic chloride Insulin beef Insulin degludec Insulin argine Insulin peglispro Insulin tregopil Fostamatinib Brigatinib Mecasermin rinfabate BMS-754807 KW-2450 free base
Diseases		Leprechaunism ; Donohue syndrome Rabson-Mendenhall syndrome
GWAS		A body shape index ( 34021172) Appendicular lean mass ( 33097823) Asthma (childhood onset) ( 27142222) Birth weight ( 31043758) Blood urea nitrogen levels ( 31152163) Chronotype (sMEQ score) ( 32579418) Diabetic retinopathy ( 21441570) Diastolic blood pressure ( 28739976 27618452 27841878) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diffusing capacity of carbon monoxide ( 30694715) Diverticular disease ( 30177863) Fasting insulin ( 34059833) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 20881960 25282103 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 25673412 28552196 34021172) Hip index ( 34021172) Hypertension ( 31879980) Hypothyroidism ( 27182965 22493691) Liver enzyme levels (alanine transaminase) ( 33972514) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Perceived unattractiveness to mosquitoes ( 28199695) Polycystic ovary syndrome ( 22885925) Pulse pressure ( 27618448 30578418) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum uric acid levels ( 30993211) Systolic blood pressure ( 30578418 28739976 27618448 27618452 28135244 27841878) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 28334899 32154731 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 30275531 24097068) Type 2 diabetes ( 32499647 30297969) Urate levels ( 23263486 31578528) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Blood protein levels ( 30072576) Metabolite levels ( 23823483) Ovarian cancer ( 23535730) Visceral fat ( 22589738)
Interacting Genes		86 interacting genes: ACP1 ADRB2 AHSG ARF1 ARHGAP26 CALM1 CALM2 CALM3 CAV1 CAV3 CBL CCDC88A CEACAM1 CRK CRKL CSK DOK1 DOK4 DOK5 DUSP18 DUSP19 ENPP1 ERBB2 FABP4 FRS2 GAB1 GRB10 GRB14 GRB7 HRAS IGF1R IGF2 INS INSRR IRF7 IRS1 IRS2 JAK1 JAK2 KHDRBS1 KRT27 KRT31 MAD2L1 MAPK3 MARCHF1 PIK3R1 PIK3R3 PLCG1 PRKCA PRKCD PTK2 PTPN1 PTPN11 PTPN12 PTPN2 PTPN6 PTPRC PTPRF PTPRR RACK1 RAF1 RASA1 SH2B1 SH2B2 SHC1 SMAD2 SNX1 SNX2 SNX4 SNX6 SOCS1 SOCS2 SOCS3 SOCS6 SORBS1 SRC STAT5A STAT5B STUB1 STYX SYNCRIP TEAD1 TRIM72 VAV1 VAV3 YWHAB	9 interacting genes: ACP1 ACTB CHD3 INSR LIPE PRKCI TNFAIP3 VIM ZBED1
Entrez ID		3643	2167
HPRD ID		00975	02698
Ensembl ID		ENSG00000171105	ENSG00000170323
Uniprot IDs		P06213	E7DVW4 P15090
PDB IDs		1GAG 1I44 1IR3 1IRK 1P14 1RQQ 2AUH 2B4S 2HR7 2MFR 2Z8C 3BU3 3BU5 3BU6 3EKK 3EKN 3ETA 3W11 3W12 3W13 4IBM 4OGA 4XLV 4XSS 4XST 4ZXB 5E1S 5HHW 5J3H 5KQV 5U1M 6HN4 6HN5 6PXV 6PXW 6SOF 6VEP 6VEQ 7BW7 7BW8 7BWA 7KD6 7MQO 7MQR 7MQS 7PG0 7PG2 7PG3 7PG4 7PHT 7QID 7S0Q 7S8V 7U6D 7U6E 7YQ3 7YQ4 7YQ5 7YQ6 8DWN 8GUY 8U4B 8U4C 8U4E 8VJB 8VJC 8X06 8X2M 8XJS 8XK1 8XKM 8XKR	1TOU 1TOW 2HNX 2NNQ 3FR2 3FR4 3FR5 3P6C 3P6D 3P6E 3P6F 3P6G 3P6H 3Q6L 3RZY 4NNS 4NNT 5D45 5D47 5D48 5D4A 5EDB 5EDC 5HZ6 5HZ8 5Y0F 5Y0G 5Y0X 5Y12 5Y13 6AYL 6LJS 6LJT 6LJU 6LJV 6LJW 6LJX 7FVU 7FVV 7FVW 7FVX 7FVY 7FVZ 7FW0 7FW1 7FW2 7FW3 7FW4 7FW5 7FW6 7FW7 7FW8 7FW9 7FWA 7FWB 7FWC 7FWD 7FWE 7FWF 7FWG 7FWH 7FWJ 7FWK 7FWL 7FWM 7FWN 7FWO 7FWP 7FWQ 7FWR 7FWS 7FWU 7FWV 7FWW 7FWX 7FWY 7FWZ 7FX0 7FX1 7FX2 7FX3 7FX4 7FX5 7FX6 7FX7 7FX8 7FX9 7FXA 7FXB 7FXC 7FXE 7FXF 7FXG 7FXH 7FXI 7FXJ 7FXK 7FXL 7FXM 7FXN 7FXP 7FXQ 7FXR 7FXS 7FXT 7FXU 7FXV 7FXW 7FXX 7FXY 7FXZ 7FY2 7FY3 7FY4 7FY5 7FY6 7FY7 7FY9 7FYB 7FYC 7FYE 7FYF 7FYG 7FYH 7FYI 7FYJ 7FYK 7FYL 7FYM 7FYO 7FYP 7FYQ 7FYR 7FYS 7FYT 7FYU 7FYV 7FYX 7FYY 7FYZ 7FZ0 7FZ1 7FZ2 7FZ3 7FZ4 7FZ5 7FZ6 7FZ7 7FZ8 7FZ9 7FZA 7FZB 7FZC 7FZD 7FZE 7FZF 7FZH 7FZI 7FZJ 7FZK 7FZL 7FZM 7FZN 7FZO 7FZP 7FZR 7FZS 7FZT 7FZU 7FZV 7FZW 7FZX 7FZY 7FZZ 7G02 7G03 7G05 7G06 7G07 7G08 7G09 7G0A 7G0C 7G0F 7G0G 7G0H 7G0I 7G0J 7G0K 7G0L 7G0M 7G0N 7G0O 7G0P 7G0Q 7G0R 7G0S 7G0T 7G0U 7G0V 7G0X 7G0Y 7G0Z 7G10 7G11 7G12 7G13 7G14 7G15 7G16 7G17 7G18 7G19 7G1A 7G1B 7G1C 7G1D 7G1E 7G1F 7G1G 7G1H 7G1I 7G1J 7G1K 7G1L 7G1M 7G1N 7G1O 7G1P 7G1R 7G1S 7G1T 7G1U 7G1V 7G1W 7G1Y 7G1Z 7G20 7G21 7WC3 8S1K 8WDX 8WE3
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Insulin Receptor Binding Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Insulin Receptor Signaling Pathway Signal Transduction Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cellular Response To Insulin Stimulus Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Phosphotyrosine Residue Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cytosol Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Multicellular Organismal Process Regulation Of Cell Adhesion Intracellular Signaling Cassette Insulin-like Growth Factor Receptor Binding ERBB Signaling Pathway Regulation Of Cell-cell Adhesion SH2 Domain Binding Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Adhesion Cytoplasm Developmental Process Negative Regulation Of Apoptotic Process Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Protein Tyrosine Phosphatase Activity Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Growth Hormone Receptor Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Transport Regulation Of Immune System Process Regulation Of Immune Response	Cytoskeleton Organization Cellular Response To Oxygen-containing Compound Response To Muramyl Dipeptide Extracellular Exosome Tight Junction Positive Regulation Of D-glucose Import Brush Border Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Positive Regulation Of D-glucose Transmembrane Transport Regulation Of D-glucose Import Regulation Of Endothelial Cell Apoptotic Process Cell Leading Edge Tolerance Induction To Lipopolysaccharide Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Protein Autosumoylation Hydrolase Activity Protein Modification Process Protein Phosphorylation Caveola Regulation Of D-glucose Transmembrane Transport Positive Regulation Of Cell Population Proliferation Phosphorylation Axon Regulation Of Norepinephrine Uptake Identical Protein Binding Diacylglycerol Lipase Activity Negative Regulation Of CD40 Signaling Pathway Schaffer Collateral - CA1 Synapse Structural Constituent Of Cytoskeleton Cellular Response To Insulin Stimulus Transporter Regulator Activity PML Body PTB Domain Binding Insulin Receptor Activity All-trans-retinyl-palmitate Hydrolase, All-trans-retinol Forming Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Osteoclast Proliferation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Localization To Plasma Membrane Regulation Of Transepithelial Transport Nuclear Matrix Insulin Receptor Complex Sterol Ester Esterase Activity Golgi Vesicle Budding Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Negative Regulation Of Chronic Inflammatory Response Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway B-1 B Cell Homeostasis
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