INSR and SH2B1

Number of citations of the paper that reports this interaction (PubMedID 9742218)
28

Data Source:
HPRD (in vitro, in vivo)

		INSR	SH2B1
Description		insulin receptor	SH2B adaptor protein 1
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GO Annotations	Cellular Component	Nuclear Envelope Lysosome Endosome Late Endosome Plasma Membrane Insulin Receptor Complex Caveola External Side Of Plasma Membrane Endosome Membrane Membrane Axon Dendrite Nuclear Lumen Dendrite Membrane Neuronal Cell Body Membrane Neuronal Cell Body Receptor Complex Cell Body Extracellular Exosome	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Amyloid-beta Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Insulin Receptor Activity Insulin-like Growth Factor Receptor Binding Structural Molecule Activity Protein Binding ATP Binding GTP Binding Kinase Activity Transferase Activity Protein Domain Specific Binding Protein Kinase Activator Activity Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Cargo Receptor Activity Identical Protein Binding Phosphatidylinositol 3-kinase Binding Insulin Binding Insulin Receptor Substrate Binding Protein-containing Complex Binding PTB Domain Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Signaling Adaptor Activity
	Biological Process	Positive Regulation Of Receptor Internalization Heart Morphogenesis Regulation Of Glycogen Biosynthetic Process Regulation Of DNA-templated Transcription Receptor-mediated Endocytosis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Learning Memory Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Epidermis Development Male Gonad Development Animal Organ Morphogenesis Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Glucose Metabolic Process Male Sex Determination Adrenal Gland Development Positive Regulation Of Cell Migration Exocrine Pancreas Development Receptor Internalization Cellular Response To Insulin Stimulus Glucose Homeostasis Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein-containing Complex Disassembly Positive Regulation Of MAPK Cascade Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Positive Regulation Of D-glucose Import Symbiont Entry Into Host Cell Protein Autophosphorylation Animal Organ Development Positive Regulation Of Developmental Growth System Development Positive Regulation Of Cellular Component Organization Regulation Of Multicellular Organismal Process Positive Regulation Of Meiotic Cell Cycle Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Respiratory Burst Cellular Response To Growth Factor Stimulus Dendritic Spine Maintenance Amyloid-beta Clearance Transport Across Blood-brain Barrier Neuron Projection Maintenance Regulation Of Female Gonad Development	Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Lamellipodium Assembly Intracellular Signal Transduction Positive Regulation Of Mitotic Nuclear Division Cell Motility Positive Regulation Of SMAD Protein Signal Transduction Regulation Of DNA Biosynthetic Process
Pathways		PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation Insulin receptor signalling cascade Signaling by Insulin receptor Insulin receptor recycling	Factors involved in megakaryocyte development and platelet production
Drugs		Insulin human Insulin lispro Insulin glargine Insulin pork Mecasermin Insulin aspart Insulin detemir Insulin glulisine Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate NN344 AT1391 Linsitinib [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID Chromic chloride Insulin beef Insulin degludec Insulin argine Insulin peglispro Insulin tregopil Fostamatinib Brigatinib Mecasermin rinfabate BMS-754807 KW-2450 free base
Diseases		Leprechaunism ; Donohue syndrome Rabson-Mendenhall syndrome
GWAS		A body shape index ( 34021172) Appendicular lean mass ( 33097823) Asthma (childhood onset) ( 27142222) Birth weight ( 31043758) Blood urea nitrogen levels ( 31152163) Chronotype (sMEQ score) ( 32579418) Diabetic retinopathy ( 21441570) Diastolic blood pressure ( 28739976 27618452 27841878) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diffusing capacity of carbon monoxide ( 30694715) Diverticular disease ( 30177863) Fasting insulin ( 34059833) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 20881960 25282103 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 25673412 28552196 34021172) Hip index ( 34021172) Hypertension ( 31879980) Hypothyroidism ( 27182965 22493691) Liver enzyme levels (alanine transaminase) ( 33972514) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Perceived unattractiveness to mosquitoes ( 28199695) Polycystic ovary syndrome ( 22885925) Pulse pressure ( 27618448 30578418) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum uric acid levels ( 30993211) Systolic blood pressure ( 30578418 28739976 27618448 27618452 28135244 27841878) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 28334899 32154731 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 30275531 24097068) Type 2 diabetes ( 32499647 30297969) Urate levels ( 23263486 31578528) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Adult body size ( 32376654) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat percentage ( 26833246) Body mass index ( 19079260 29381148 28448500 19079261 20935630) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Cognitive ability ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Crohn's disease ( 28067908 21102463) Dental caries (decayed, missing and filled teeth) ( 31533690) Educational attainment ( 25201988) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) Inflammatory bowel disease ( 28067908) Intelligence ( 28530673) Lamb consumption ( 32066663) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Obesity ( 23563607) QT interval ( 29213071) Red blood cell count ( 32888494 27863252) Waist circumference ( 25673412) Weight ( 19079260)
Interacting Genes		86 interacting genes: ACP1 ADRB2 AHSG ARF1 ARHGAP26 CALM1 CALM2 CALM3 CAV1 CAV3 CBL CCDC88A CEACAM1 CRK CRKL CSK DOK1 DOK4 DOK5 DUSP18 DUSP19 ENPP1 ERBB2 FABP4 FRS2 GAB1 GRB10 GRB14 GRB7 HRAS IGF1R IGF2 INS INSRR IRF7 IRS1 IRS2 JAK1 JAK2 KHDRBS1 KRT27 KRT31 MAD2L1 MAPK3 MARCHF1 PIK3R1 PIK3R3 PLCG1 PRKCA PRKCD PTK2 PTPN1 PTPN11 PTPN12 PTPN2 PTPN6 PTPRC PTPRF PTPRR RACK1 RAF1 RASA1 SH2B1 SH2B2 SHC1 SMAD2 SNX1 SNX2 SNX4 SNX6 SOCS1 SOCS2 SOCS3 SOCS6 SORBS1 SRC STAT5A STAT5B STUB1 STYX SYNCRIP TEAD1 TRIM72 VAV1 VAV3 YWHAB	19 interacting genes: CRK CSAD EGFR ERBB2 ERBB3 ERBB4 FGFR3 FRS3 GRB2 HUNK IGF1R INSR JAK2 KIAA0319 MET NTRK1 NTRK2 RHBG SH2B2
Entrez ID		3643	25970
HPRD ID		00975	12336
Ensembl ID		ENSG00000171105	ENSG00000178188
Uniprot IDs		P06213	B3KNV5 B4DLN5 Q9NRF2
PDB IDs		1GAG 1I44 1IR3 1IRK 1P14 1RQQ 2AUH 2B4S 2HR7 2MFR 2Z8C 3BU3 3BU5 3BU6 3EKK 3EKN 3ETA 3W11 3W12 3W13 4IBM 4OGA 4XLV 4XSS 4XST 4ZXB 5E1S 5HHW 5J3H 5KQV 5U1M 6HN4 6HN5 6PXV 6PXW 6SOF 6VEP 6VEQ 7BW7 7BW8 7BWA 7KD6 7MQO 7MQR 7MQS 7PG0 7PG2 7PG3 7PG4 7PHT 7QID 7S0Q 7S8V 7U6D 7U6E 7YQ3 7YQ4 7YQ5 7YQ6 8DWN 8GUY 8U4B 8U4C 8U4E 8VJB 8VJC 8X06 8X2M 8XJS 8XK1 8XKM 8XKR	5W3R
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Insulin Receptor Binding Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Insulin Receptor Signaling Pathway Signal Transduction Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cellular Response To Insulin Stimulus Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Phosphotyrosine Residue Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cytosol Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Multicellular Organismal Process Regulation Of Cell Adhesion Intracellular Signaling Cassette Insulin-like Growth Factor Receptor Binding ERBB Signaling Pathway Regulation Of Cell-cell Adhesion SH2 Domain Binding Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Adhesion Cytoplasm Developmental Process Negative Regulation Of Apoptotic Process Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Protein Tyrosine Phosphatase Activity Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Growth Hormone Receptor Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Transport Regulation Of Immune System Process Regulation Of Immune Response	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Receptor Complex Protein Kinase Activity Kinase Activity Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Insulin Receptor Substrate Binding Peptidyl-tyrosine Phosphorylation ATP Binding Protein Autophosphorylation Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane ERBB2 Signaling Pathway Positive Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Plasma Membrane ERBB Signaling Pathway Nucleotide Binding Transferase Activity Response To Growth Factor Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Phosphorylation Neuron Differentiation Signal Transduction Phosphorylation Regulation Of Signal Transduction Cell Development Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation Identical Protein Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Endosome Regulation Of Cell Communication Regulation Of Signaling Phosphatidylinositol 3-kinase Binding Cellular Developmental Process Positive Regulation Of Phosphate Metabolic Process Schwann Cell Development ERBB3:ERBB2 Complex Regulation Of Catalytic Activity Regulation Of Peptidyl-tyrosine Phosphorylation
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