IMPDH2 and UBQLN4

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		IMPDH2	UBQLN4
Gene Name		IMP (inosine 5-monophosphate) dehydrogenase 2	ubiquilin 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Peroxisomal Membrane Cytosol Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Nuclear Proteasome Complex Cytosolic Proteasome Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding DNA Binding RNA Binding IMP Dehydrogenase Activity Metal Ion Binding	Protein Binding Polyubiquitin Binding Identical Protein Binding
	Biological Process	Purine Nucleobase Metabolic Process GMP Biosynthetic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Small Molecule Metabolic Process Lymphocyte Proliferation Protein Homotetramerization Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process Retina Development In Camera-type Eye Cellular Response To Interleukin-4	Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways		Purine ribonucleoside monophosphate biosynthesis Purine metabolism Metabolism of nucleotides
Drugs		NADH Mycophenolate mofetil Mycophenolic acid Ribavirin Monophosphate Nicotinamide-Adenine-Dinucleotide Selenazole-4-Carboxyamide-Adenine Dinucleotide 6-Chloropurine Riboside, 5\'-Monophosphate Inosinic Acid
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		6 interactors: AKT1 APIP PIAS4 RSG1 SUMO4 UBQLN4	157 interactors: ADAM33 ADPGK AGR2 ANKRD13D AREG ARL4C ATPIF1 ATXN1 BAG6 BPIFA1 C11orf49 C1orf94 C1QTNF1 CACNA1G CCDC107 CCDC134 CCDC136 CCDC14 CCDC33 CCL21 CD99 CDSN CEND1 COL8A1 COPB1 CPSF6 CRIPT CSTF2 CSTF2T CTSB CYB5R1 DAZAP2 DKK3 DMPK DNAJB11 DTX2 EAPP EDN1 EEF1A1 EFEMP2 ELF5 EPDR1 ERP27 ERP29 FA2H FGFBP1 FKBP2 FKBP7 FZD7 GABRD GDI1 GKAP1 GPX7 HAVCR1 HGS HK2 HSPA13 HSPA5 IGFBP6 IGHM IGLC1 IMMT IMPDH2 ITPRIPL1 KLHL26 KLHL42 LAT2 MDK MDM2 MIEF2 MIF4GD MLLT6 MOAP1 MYDGF NAE1 NME3 NOMO1 NOMO3 NOTCH2NL NPHP1 NPPA NXF1 OAT ORC5 PBXIP1 PCDH17 PCDH8 PDIA5 PDLIM7 PELI2 PICK1 PIN1 PIP4K2B PLA2G16 PMEPA1 PNMA1 PPIB PPIC PRL PRPF40A PSMD4 PTN PTPRN PTPRN2 QSOX1 RAD23A RAI2 RBM10 RIC8A RNF11 RNPS1 ROBO2 RPN1 RSRC2 RUNX1T1 RXRA SCAF1 SCG2 SCG5 SCMH1 SEMG1 SERPINE1 SERPINH1 SERPINI2 SMAD3 SMAD9 SMARCB1 SPAG8 SPINT1 SPP1 SRGN SRSF2 STAM2 STMN1 SUPT20H TFF1 TGFB1I1 TNFRSF14 TNRC6B TRAF2 TRIB2 TRIM32 UBQLN1 UBQLN2 UBR7 UNC119 UROS USMG5 VIP WAC YWHAQ ZBTB22 ZDHHC3 ZFPM2 ZG16 ZG16B ZNF205
Entrez ID		3615	56893
HPRD ID		00895	05670
Ensembl ID		ENSG00000178035	ENSG00000160803
Uniprot IDs		P12268	B4DZF6 Q9NRR5
PDB IDs		1B3O 1NF7 1NFB
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Glycogen Cell Differentiation Involved In Embryonic Placenta Development Protein Modification By Small Protein Conjugation Positive Regulation Of Keratinocyte Apoptotic Process L-methionine Biosynthetic Process From S-adenosylmethionine Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Fatty Acid Beta-oxidation Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway Peptidyl-amino Acid Modification S-adenosylmethionine Cycle Response To UV-A Activation-induced Cell Death Of T Cells Peptidyl-lysine Modification Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus L-methionine Biosynthetic Process From Methylthioadenosine L-methionine Salvage Negative Regulation Of Fatty Acid Oxidation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Sumoylation Positive Regulation Of Glycogen Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Protein Catabolic Process Negative Regulation Of Cell Size Regulation Of Apoptotic Process Methionine Biosynthetic Process Spongiotrophoblast Layer Development Negative Regulation Of Release Of Cytochrome C From Mitochondria S-adenosylmethionine Metabolic Process T Cell Apoptotic Process Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Death Methionine Metabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Protein Sumoylation Insulin-like Growth Factor Receptor Signaling Pathway Sulfur Amino Acid Biosynthetic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Peripheral Nervous System Myelin Maintenance Response To Food Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Fatty Acid Metabolic Process Negative Regulation Of Lipid Transport	Regulation Of Cellular Process Response To Stress Positive Regulation Of Cellular Metabolic Process Response To Stimulus Signaling Signal Transduction Cell Communication Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Multicellular Organismal Development Positive Regulation Of Metabolic Process Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Cell Proliferation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transport Organ Development Positive Regulation Of Mitochondrion Organization Regulation Of Cellular Localization Regulation Of Proteolysis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Developmental Process Response To Organic Substance Tissue Development Regulation Of Metabolic Process Positive Regulation Of Gene Expression Anatomical Structure Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Behavior Regulation Of Phosphorus Metabolic Process System Development Protein Peptidyl-prolyl Isomerization Regulation Of Signaling Negative Regulation Of Cell Proliferation Regulation Of Body Fluid Levels Regulation Of Chemotaxis Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Cellular Localization Defense Response Regulation Of Mitochondrion Organization Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cellular Component Organization
Tagcloud ?		biogenesis biosynthesis dehydrogenase deoxy disrupts dually genotoxic gtp guanine inauzhin inosine inz mdm2 monophosphate notion nucleostemin pools ribonucleotide ribosomal rpl11 rpl5 rps rrna rs sirt1 stressor suppresses surprisingly
Tagcloud (Difference) ?		biogenesis biosynthesis dehydrogenase deoxy disrupts dually genotoxic gtp guanine inauzhin inosine inz mdm2 monophosphate notion nucleostemin pools ribonucleotide ribosomal rpl11 rpl5 rps rrna rs sirt1 stressor suppresses surprisingly
Tagcloud (Intersection) ?