IMPDH2 and SUMO4

Number of citations of the paper that reports this interaction (PMID 16236267)
15

Data Source:
HPRD (in vivo)

		IMPDH2	SUMO4
Gene Name		IMP (inosine 5-monophosphate) dehydrogenase 2	small ubiquitin-like modifier 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Peroxisomal Membrane Cytosol Membrane Extracellular Vesicular Exosome	Nucleus
	Molecular Function	Nucleotide Binding DNA Binding RNA Binding IMP Dehydrogenase Activity Metal Ion Binding
	Biological Process	Purine Nucleobase Metabolic Process GMP Biosynthetic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Small Molecule Metabolic Process Lymphocyte Proliferation Protein Homotetramerization Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process Retina Development In Camera-type Eye Cellular Response To Interleukin-4	Protein Sumoylation
Pathways		Purine ribonucleoside monophosphate biosynthesis Purine metabolism Metabolism of nucleotides
Drugs		NADH Mycophenolate mofetil Mycophenolic acid Ribavirin Monophosphate Nicotinamide-Adenine-Dinucleotide Selenazole-4-Carboxyamide-Adenine Dinucleotide 6-Chloropurine Riboside, 5\'-Monophosphate Inosinic Acid
Diseases
GWAS
Protein-Protein Interactions		6 interactors: AKT1 APIP PIAS4 RSG1 SUMO4 UBQLN4	75 interactors: ACADM ACO2 ACTG1 ALDOA ARHGDIA ATP5B CALR CAT CCT2 CCT5 CCT6A CCT7 CLIC1 DNAJA1 DNAJB11 EIF3I ENO1 ENO2 FOS G6PD GAPDH GMPS GNB2L1 GSTP1 HNRNPD HNRNPF HNRNPH1 HNRNPL HSPA1B HSPA5 HSPA8 HSPA9 HSPD1 IDH1 IDH3A IMPDH2 JUN LDHB LMNA LMNB1 MRPS22 NFKBIA NR3C1 PA2G4 PAFAH1B3 PDIA3 PDIA6 PGK1 PHB PHGDH PITHD1 PPA1 PRDX2 PRDX3 PRDX4 PRDX6 PRPS1 PSMC2 RPSA SF3B4 SPINT2 STAT1 STAT3 STIP1 STOML2 STRAP TFAP2A TOP2A TPM3 TUBA1C TXNL1 UBE2V1 VCP VDAC1 ZPR1
Entrez ID		3615	387082
HPRD ID		00895	10584
Ensembl ID		ENSG00000178035	ENSG00000177688
Uniprot IDs		P12268	Q6EEV6
PDB IDs		1B3O 1NF7 1NFB
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Glycogen Cell Differentiation Involved In Embryonic Placenta Development Protein Modification By Small Protein Conjugation Positive Regulation Of Keratinocyte Apoptotic Process L-methionine Biosynthetic Process From S-adenosylmethionine Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Fatty Acid Beta-oxidation Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway Peptidyl-amino Acid Modification S-adenosylmethionine Cycle Response To UV-A Activation-induced Cell Death Of T Cells Peptidyl-lysine Modification Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus L-methionine Biosynthetic Process From Methylthioadenosine L-methionine Salvage Negative Regulation Of Fatty Acid Oxidation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Sumoylation Positive Regulation Of Glycogen Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Protein Catabolic Process Negative Regulation Of Cell Size Regulation Of Apoptotic Process Methionine Biosynthetic Process Spongiotrophoblast Layer Development Negative Regulation Of Release Of Cytochrome C From Mitochondria S-adenosylmethionine Metabolic Process T Cell Apoptotic Process Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Death Methionine Metabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Protein Sumoylation Insulin-like Growth Factor Receptor Signaling Pathway Sulfur Amino Acid Biosynthetic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Peripheral Nervous System Myelin Maintenance Response To Food Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Fatty Acid Metabolic Process Negative Regulation Of Lipid Transport	Protein Folding Regulation Of Cell Death Regulation Of Apoptotic Process Cellular Metabolic Process Response To Unfolded Protein Response To Stress Negative Regulation Of Cell Death 'de Novo' Protein Folding Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Toxin Transport Response To Organic Substance Nitrogen Compound Metabolic Process 'de Novo' Posttranslational Protein Folding Metabolic Process Cellular Response To Stress Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Response To Endoplasmic Reticulum Stress Generation Of Precursor Metabolites And Energy Regulation Of Cellular Protein Metabolic Process Response To Oxidative Stress Positive Regulation Of Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Process Response To Reactive Oxygen Species Small Molecule Metabolic Process Organic Acid Metabolic Process Hydrogen Peroxide Catabolic Process Regulation Of Protein Metabolic Process Carboxylic Acid Metabolic Process Protein Refolding Endoplasmic Reticulum Unfolded Protein Response Ribonucleoside Monophosphate Biosynthetic Process Carbohydrate Biosynthetic Process Cellular Response To Organic Substance MRNA Metabolic Process Cellular Response To Unfolded Protein Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Nucleoside Monophosphate Biosynthetic Process Gluconeogenesis Monocarboxylic Acid Metabolic Process ER-nucleus Signaling Pathway Catabolic Process Ribose Phosphate Biosynthetic Process Apoptotic Process Biosynthetic Process Cellular Response To Topologically Incorrect Protein
Tagcloud ?		biogenesis biosynthesis dehydrogenase deoxy disrupts dually genotoxic gtp guanine inauzhin inosine inz mdm2 monophosphate notion nucleostemin pools ribonucleotide ribosomal rpl11 rpl5 rps rrna rs sirt1 stressor suppresses surprisingly	accumulating behcet ccr1 ccr3 ccr6 cd40 ctla4 elucidating fcrl3 han helpful hopefully il17 il23r immunoregulatory irf5 l2 mcp multisystemic mystery opn predisposition profound ptpn22 regimes stat4 tgfbr3 tgrbr3 ubac2
Tagcloud (Difference) ?		biogenesis biosynthesis dehydrogenase deoxy disrupts dually genotoxic gtp guanine inauzhin inosine inz mdm2 monophosphate notion nucleostemin pools ribonucleotide ribosomal rpl11 rpl5 rps rrna rs sirt1 stressor suppresses surprisingly	accumulating behcet ccr1 ccr3 ccr6 cd40 ctla4 elucidating fcrl3 han helpful hopefully il17 il23r immunoregulatory irf5 l2 mcp multisystemic mystery opn predisposition profound ptpn22 regimes stat4 tgfbr3 tgrbr3 ubac2
Tagcloud (Intersection) ?