IMPDH2

Gene Name		IMP (inosine 5-monophosphate) dehydrogenase 2
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Peroxisomal Membrane Cytosol Membrane Extracellular Vesicular Exosome
	Molecular Function	Nucleotide Binding DNA Binding RNA Binding IMP Dehydrogenase Activity Metal Ion Binding
	Biological Process	Purine Nucleobase Metabolic Process GMP Biosynthetic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Small Molecule Metabolic Process Lymphocyte Proliferation Protein Homotetramerization Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process Retina Development In Camera-type Eye Cellular Response To Interleukin-4
Pathways		Purine ribonucleoside monophosphate biosynthesis Purine metabolism Metabolism of nucleotides
Drugs		NADH Mycophenolate mofetil Mycophenolic acid Ribavirin Monophosphate Nicotinamide-Adenine-Dinucleotide Selenazole-4-Carboxyamide-Adenine Dinucleotide 6-Chloropurine Riboside, 5\'-Monophosphate Inosinic Acid
Diseases
GWAS
Protein-protein Interactions		6 interactors: AKT1 APIP PIAS4 RSG1 SUMO4 UBQLN4
Entrez ID		3615
HPRD ID		00895
Ensembl ID		ENSG00000178035
Uniprot IDs		P12268
PDB IDs		1B3O 1NF7 1NFB
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Glycogen Cell Differentiation Involved In Embryonic Placenta Development Protein Modification By Small Protein Conjugation Positive Regulation Of Keratinocyte Apoptotic Process L-methionine Biosynthetic Process From S-adenosylmethionine Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Fatty Acid Beta-oxidation Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway Peptidyl-amino Acid Modification S-adenosylmethionine Cycle Response To UV-A Activation-induced Cell Death Of T Cells Peptidyl-lysine Modification Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus L-methionine Biosynthetic Process From Methylthioadenosine L-methionine Salvage Negative Regulation Of Fatty Acid Oxidation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Sumoylation Positive Regulation Of Glycogen Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Protein Catabolic Process Negative Regulation Of Cell Size Regulation Of Apoptotic Process Methionine Biosynthetic Process Spongiotrophoblast Layer Development Negative Regulation Of Release Of Cytochrome C From Mitochondria S-adenosylmethionine Metabolic Process T Cell Apoptotic Process Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Death Methionine Metabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Protein Sumoylation Insulin-like Growth Factor Receptor Signaling Pathway Sulfur Amino Acid Biosynthetic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Peripheral Nervous System Myelin Maintenance Response To Food Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Fatty Acid Metabolic Process Negative Regulation Of Lipid Transport
Tagcloud ?		biogenesis biosynthesis dehydrogenase deoxy disrupts dually genotoxic gtp guanine inauzhin inosine inz mdm2 monophosphate notion nucleostemin pools ribonucleotide ribosomal rpl11 rpl5 rps rrna rs sirt1 stressor suppresses surprisingly