IMPDH2 and POU6F2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IMPDH2	POU6F2
Description		inosine monophosphate dehydrogenase 2	POU class 6 homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Peroxisomal Membrane Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Chromatin Nucleus
	Molecular Function	Nucleotide Binding DNA Binding RNA Binding Catalytic Activity IMP Dehydrogenase Activity Protein Binding Oxidoreductase Activity Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Purine Nucleotide Biosynthetic Process GMP Biosynthetic Process GTP Biosynthetic Process Circadian Rhythm Lymphocyte Proliferation Cellular Response To Interleukin-4 'de Novo' XMP Biosynthetic Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Visual Perception
Pathways		Neutrophil degranulation Purine ribonucleoside monophosphate biosynthesis Potential therapeutics for SARS Azathioprine ADME
Drugs		NADH Mycophenolate mofetil Ribavirin Mycophenolic acid Mercaptopurine Selenazole-4-carboxyamide-adenine dinucleotide 6-Chloropurine Riboside, 5'-Monophosphate Inosinic Acid VX-148
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Adult body size ( 32376654) Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Caffeine consumption from tea ( 33287642) Feeling hurt ( 29500382) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 33627673) Hand grip strength ( 29691431) Intraocular pressure ( 29785010 30054594 31959993) Motion sickness ( 25628336) Refractive error ( 32231278) Tea consumption ( 31046077)
Interacting Genes		17 interacting genes: AGR2 AKT1 APIP CEBPA CLK1 CPLANE2 FXR1 FXR2 IL1F10 OGT PIAS4 POU6F2 STAT3 SUMO2 SUMO4 TRAF2 UBQLN4	143 interacting genes: ACTN3 AIRIM ANKRD10 ARHGEF6 ASB13 BANP BFSP2 BHLHE40 C5 CCHCR1 CCNC CCNK CDC23 CDC37 CDKN2C CHAF1A CIB3 CINP CSNK2A1 CSTF2 CTNNA3 DDX6 DTNB DYDC1 EBF1 EIF3F EIF4EBP1 EPHB6 FHL2 FNDC3B FOSB GCM2 GLIS2 GMEB2 GOLGA6L9 HGS HIVEP1 HNF1B HOXC5 HOXC8 HSPA4 IGFN1 IMPDH2 IQUB IRX4 ISX KDF1 KIF5B KLHL11 KPNA5 KPNA6 KRTAP8-1 L3MBTL2 LARP4 LMNB2 LMO3 LNX1 LONRF1 MAGEA12 MAPK9 MEIS2 MIEN1 MLLT10 MORF4L2 MSRB3 MSX2 MYL7 MYO15B NEUROG3 NFYC NKX3-2 NME7 NUP62CL OAZ3 OIP5 OPLAH OPTN PADI4 PARVG PDE6H PIBF1 PKN1 PM20D2 POLR3C POU2F1 PPIL1 PPIP5K2 PROP1 PRR20A PRR20B PRR20C PRR20D PRR20E QRICH1 RAD23B RBM39 RBPMS RELA SIX1 SMAD5 SMYD1 SORL1 SOX10 SSUH2 STAC STRA8 TBX6 TCEA2 TENT5B THADA THAP1 TLX2 TLX3 TNPO2 TNXB TP53BP1 TRIM73 TRIML2 TSC1 TSEN15 TTC19 TTC23 UBAC1 UFSP1 VAX2 VENTX VEZF1 VPS9D1 XPOT ZBTB24 ZBTB4 ZFHX2 ZFHX3 ZFP1 ZFP91 ZIM2 ZMYND12 ZNF148 ZNF319 ZNF34 ZNF384 ZNF410 ZNF574
Entrez ID		3615	11281
HPRD ID		00895	10162
Ensembl ID		ENSG00000178035	ENSG00000106536
Uniprot IDs		A0A7I2YQK5 E7ETK5 H0Y4R1 P12268	A0A6E1XZL4 P78424
PDB IDs		1B3O 1NF7 1NFB 6I0M 6I0O 6U8E 6U8N 6U8R 6U8S 6U9O 6UA2 6UA4 6UA5 6UAJ 6UC2 6UDO 6UDP 6UDQ 8FOZ 8FUZ 8G8F 8G9B 9DMU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Regulation Of MRNA Stability Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Metabolic Process Regulation Of RNA Stability Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Positive Regulation Of Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Translation Identical Protein Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process TOR Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Primary Metabolic Process Carbohydrate Homeostasis Glucose Homeostasis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Protein Homodimerization Activity Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Gene Expression Inflammatory Response Negative Regulation Of Double-strand Break Repair Positive Regulation Of MRNA Catabolic Process Regulation Of Protein Catabolic Process Protein-containing Complex Negative Regulation Of Catabolic Process Negative Regulation Of DNA Repair Glutamatergic Synapse Negative Regulation Of Translational Initiation Cytokine-mediated Signaling Pathway Regulation Of Translation Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA Recombination Positive Regulation Of Long-term Neuronal Synaptic Plasticity Protein Sumoylation Defense Response Positive Regulation Of MRNA Metabolic Process	Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleus Sequence-specific Double-stranded DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Protein Binding Chromatin Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Pattern Specification Process Negative Regulation Of DNA-templated Transcription Sequence-specific DNA Binding Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Zinc Ion Binding Transcription Cis-regulatory Region Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Branch Elongation Involved In Ureteric Bud Branching Stem Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Nuclear Import Signal Receptor Activity Animal Organ Development Activation Of Meiosis Nuclear Localization Sequence Binding DNA-templated Transcription
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