IMPDH2 and CLK1

Number of citations of the paper that reports this interaction (PubMedID 26167880)
0

Data Source:
BioGRID (enzymatic study)

		IMPDH2	CLK1
Description		inosine monophosphate dehydrogenase 2	CDC like kinase 1
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Peroxisomal Membrane Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus
	Molecular Function	Nucleotide Binding DNA Binding RNA Binding Catalytic Activity IMP Dehydrogenase Activity Protein Binding Oxidoreductase Activity Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Purine Nucleotide Biosynthetic Process GMP Biosynthetic Process GTP Biosynthetic Process Circadian Rhythm Lymphocyte Proliferation Cellular Response To Interleukin-4 'de Novo' XMP Biosynthetic Process	Regulation Of RNA Splicing
Pathways		Neutrophil degranulation Purine ribonucleoside monophosphate biosynthesis Potential therapeutics for SARS Azathioprine ADME
Drugs		NADH Mycophenolate mofetil Ribavirin Mycophenolic acid Mercaptopurine Selenazole-4-carboxyamide-adenine dinucleotide 6-Chloropurine Riboside, 5'-Monophosphate Inosinic Acid VX-148	Debromohymenialdisine CHGN111 ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate Fostamatinib
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Triptolide cytotoxicity ( 26121980)
Interacting Genes		17 interacting genes: AGR2 AKT1 APIP CEBPA CLK1 CPLANE2 FXR1 FXR2 IL1F10 OGT PIAS4 POU6F2 STAT3 SUMO2 SUMO4 TRAF2 UBQLN4	170 interacting genes: ABCA13 ACOX2 ANKFY1 ARHGEF12 ARPC4 ASL ASXL3 ATP10A ATP4A BCLAF1 C1orf94 CDCP1 CDH23 CDK12 CELSR3 CENPE CEP95 CFAP20DC CFAP251 CKAP5 CLASRP CLK2 COCH CRNKL1 CTNND2 CUL3 CWC27 CYP46A1 DBR1 DDX23 DENND4A DNAJC13 DNAJC24 DOCK9 DPYD DSC2 DVL3 ECE1 ELP6 ENO1 ENTREP2 ERFE FAT1 FBF1 FHIP2B GEMIN5 GOLM1 GRM6 GSDMB H2BC12 HADH HIVEP1 HNMT HNRNPA0 HNRNPA1 HNRNPA3 HSP90AB2P HSPBP1 HTATSF1 ICE1 IMPDH2 IP6K1 ITGA5 KATNA1 KHDRBS1 KIF14 KIF23 KRT8 KRTAP10-6 KRTAP10-7 LINS1 LMNA LNX1 LUC7L3 MAP3K21 MAP7 MBP MFHAS1 MICU3 MKRN2 MTBP MTCL1 MTPAP MYOM1 NCL NCOR1 NF1 NPM1 NUP153 PATZ1 PDE9A PHF3 PHLDB2 PIAS4 PIGP PIP4K2B PKD1L1 PLAAT5 PLXDC2 PPFIBP2 PPHLN1 PPIG PPP1CB PRDX5 PRKDC PRMT5 PRP4K PRPF38A PRPF4 PTPN1 PTPN22 RAD21L1 RAPH1 RASL12 RBBP6 RBM15 RBMX REV1 RLF RPL5 RPS4Y1 RPUSD3 SAFB SAMD9L SCARA3 SERPINI2 SF3B1 SFMBT2 SH2B2 SHROOM1 SLC35D3 SLC75A1 SLFN5 SPEN SPTBN4 SRPK1 SRPK2 SRRM1 SRRM2 SRRM4 SRSF1 SRSF10 SRSF12 SRSF6 SRSF8 SSBP3 STIP1 STK31 SVOP TDRD9 TEX11 THRAP3 THY1 TJP2 TLN2 TMPO TMPRSS2 TNIP2 TP53RK TRA2B UBL5 UNC13B VWA7 YTHDC1 YWHAG ZC3H13 ZMYND10 ZNF148 ZNF830 ZRSR2
Entrez ID		3615	1195
HPRD ID		00895	09058
Ensembl ID		ENSG00000178035	ENSG00000013441
Uniprot IDs		A0A7I2YQK5 E7ETK5 H0Y4R1 P12268	P49759
PDB IDs		1B3O 1NF7 1NFB 6I0M 6I0O 6U8E 6U8N 6U8R 6U8S 6U9O 6UA2 6UA4 6UA5 6UAJ 6UC2 6UDO 6UDP 6UDQ 8FOZ 8FUZ 8G8F 8G9B 9DMU	1Z57 2VAG 5J1V 5J1W 5X8I 6FT8 6FT9 6FYO 6G33 6I5H 6I5I 6I5K 6I5L 6KHD 6Q8K 6Q8P 6QTY 6R3D 6R6E 6R6X 6R8J 6RAA 6TW2 6YTA 6YTD 6YTE 6YTG 6YTI 6Z4Z 6Z50 6ZLN 7AK3 7O9Y 7OA0 7OPG 8P04 8P08 8UWN
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Regulation Of MRNA Stability Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Metabolic Process Regulation Of RNA Stability Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Positive Regulation Of Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Translation Identical Protein Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process TOR Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Primary Metabolic Process Carbohydrate Homeostasis Glucose Homeostasis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Protein Homodimerization Activity Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Gene Expression Inflammatory Response Negative Regulation Of Double-strand Break Repair Positive Regulation Of MRNA Catabolic Process Regulation Of Protein Catabolic Process Protein-containing Complex Negative Regulation Of Catabolic Process Negative Regulation Of DNA Repair Glutamatergic Synapse Negative Regulation Of Translational Initiation Cytokine-mediated Signaling Pathway Regulation Of Translation Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA Recombination Positive Regulation Of Long-term Neuronal Synaptic Plasticity Protein Sumoylation Defense Response Positive Regulation Of MRNA Metabolic Process	MRNA Processing RNA Splicing MRNA Metabolic Process RNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing RNA Metabolic Process RNA Binding Nuclear Speck Regulation Of Alternative MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly Regulation Of MRNA Metabolic Process Spliceosomal Complex Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding Catalytic Step 2 Spliceosome Nucleoplasm Nucleic Acid Binding MRNA Splice Site Recognition Nucleus Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of RNA Splicing Negative Regulation Of RNA Splicing Protein-containing Complex Assembly Spliceosomal Complex Assembly Positive Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Metabolic Process Protein-containing Complex Organization RS Domain Binding Spliceosomal SnRNP Assembly U2-type Precatalytic Spliceosome Nuclear Matrix Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity DNA Topoisomerase Binding
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