ILF2 and EIF2AK2

Number of citations of the paper that reports this interaction (PMID 11438540)
25

Data Source:
BioGRID (enzymatic study)

		ILF2	EIF2AK2
Gene Name		interleukin enhancer binding factor 2	eukaryotic translation initiation factor 2-alpha kinase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane Ribonucleoprotein Complex	Nucleus Cytoplasm Cytosol Ribosome Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Double-stranded RNA Binding Protein Binding ATP Binding Transferase Activity Poly(A) RNA Binding	Double-stranded RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Type 2A Regulator Activity Poly(A) RNA Binding
	Biological Process	Transcription, DNA-templated Immune Response Positive Regulation Of Transcription, DNA-templated	Activation Of MAPKK Activity Positive Regulation Of Cytokine Production Transcription, DNA-templated Translation Protein Phosphorylation Negative Regulation Of Cell Proliferation Response To Virus Negative Regulation Of Translation Peptidyl-tyrosine Phosphorylation Modulation By Virus Of Host Morphology Or Physiology Modulation By Virus Of Host Process Viral Life Cycle Evasion Or Tolerance By Virus Of Host Immune Response Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Chemokine Production Positive Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Proliferation Response To Interferon-alpha Negative Regulation Of Apoptotic Process Negative Regulation Of Viral Genome Replication Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Hematopoietic Stem Cell Differentiation
Pathways			ISG15 antiviral mechanism Interferon Signaling Inhibition of PKR Cytokine Signaling in Immune system Host Interactions with Influenza Factors Influenza Infection NS1 Mediated Effects on Host Pathways Antiviral mechanism by IFN-stimulated genes
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CCNDBP1 EEF1G EIF2AK2 ERG IL7R PRKDC SGSM2 SREK1	48 interactors: CASP3 CASP7 CASP8 CDC42 CHUK DHX30 DHX58 DHX9 DICER1 DNAJC3 EDC4 EIF2S1 EIF6 ELF2 FTSJ3 HIST2H2AC HSP90AA1 HSPA1A IKBKB IL7R ILF2 ILF3 JAK1 MAP3K5 MAP3K7 METAP2 MOV10 NFKBIA NPM1 PDGFRB PPP1CA PPP1CC PPP2R5A PRKRA PRKRIP1 PRKRIR PTGES3 RAC1 STAT1 STAT3 STRBP TAB2 TARBP2 TIRAP TOLLIP TP53 TYK2 ZNF346
Entrez ID		3608	5610
HPRD ID		04419	01468
Ensembl ID		ENSG00000143621	ENSG00000055332
Uniprot IDs		B4DY09 F4ZW62 Q12905 Q53FG3	B7ZKK7 P19525 Q8IW76
PDB IDs			1QU6 2A19 2A1A 3UIU
Enriched GO Terms of Interacting Partners?		Immunoglobulin Production Evasion Or Tolerance By Virus Of Host Immune Response Negative Regulation Of Potassium Ion Export Interleukin-7-mediated Signaling Pathway Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Heart Rate By Hormone Evasion Or Tolerance Of Host Defenses By Virus Late Endosome To Golgi Transport T Cell Differentiation B Cell Activation Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Pro-B Cell Differentiation Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of T Cell Mediated Cytotoxicity Response To Host Immune Response Lymphocyte Differentiation Immunoglobulin V(D)J Recombination Regulation Of NLRP3 Inflammasome Complex Assembly Peptidyl-amino Acid Modification T Cell Receptor V(D)J Recombination B Cell Lineage Commitment Regulation Of Heart Rate By Chemical Signal Response To Virus Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Peptidyl-histidine Phosphorylation Potassium Ion Export Lymphoid Progenitor Cell Differentiation Regulation Of Translational Initiation In Response To Stress T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Negative Regulation Of Osteoblast Proliferation Ectopic Germ Cell Programmed Cell Death Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Membrane Repolarization Negative Regulation Of T Cell Mediated Immunity Modulation By Virus Of Host Process Leukocyte Cell-cell Adhesion Negative Regulation Of Potassium Ion Transmembrane Transport Potassium Ion Homeostasis Homotypic Cell-cell Adhesion Leukocyte Differentiation Lymph Node Development Positive Regulation Of T Cell Differentiation In Thymus Phosphorelay Signal Transduction System Regulation Of Translation In Response To Stress Response To Interferon-alpha Positive Regulation Of Potassium Ion Transmembrane Transport	Immune Response Defense Response Immune System Process Innate Immune Response Response To Stress Response To Organic Substance Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Immune System Process Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Metabolic Process Response To Stimulus Regulation Of Cell Death Response To External Stimulus Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Stimulus Regulation Of Apoptotic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Fc Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Signal Transduction Toll-like Receptor 4 Signaling Pathway Regulation Of Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Posttranscriptional Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Response To Biotic Stimulus Response To Abiotic Stimulus Signaling Response To Growth Factor Response To Virus Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor Signaling Pathway Toll-like Receptor 2 Signaling Pathway Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Kinase Activity TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Metabolic Process Response To DsRNA Positive Regulation Of Intracellular Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway
Tagcloud ?		abrogates acetylation acetyltransferase cd34 cognate complex contains erythroid erythroleukemic existence globin ilf3 imply intricately k562 link links locus multiprotein obscure origin recruitment repair replication rnai surveyed transcription usage validated	c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1 tbl1x
Tagcloud (Difference) ?		abrogates acetylation acetyltransferase cd34 cognate complex contains erythroid erythroleukemic existence globin ilf3 imply intricately k562 link links locus multiprotein obscure origin recruitment repair replication rnai surveyed transcription usage validated	c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1 tbl1x
Tagcloud (Intersection) ?