ILF2 and EIF2AK2

Number of citations of the paper that reports this interaction (PubMedID 11438540)
0

Data Source:
BioGRID (enzymatic study)

		ILF2	EIF2AK2
Description		interleukin enhancer binding factor 2	eukaryotic translation initiation factor 2 alpha kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Specific Granule Lumen Tertiary Granule Lumen Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Ribosome Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding RNA Binding Double-stranded RNA Binding Protein Binding	Nucleotide Binding RNA Binding Double-stranded RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Regulator Activity Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	Positive Regulation Of DNA-templated Transcription	Positive Regulation Of Cytokine Production Immune System Process Translation Translational Initiation Regulation Of Translational Initiation Protein Phosphorylation Negative Regulation Of Cell Population Proliferation Response To Virus Negative Regulation Of Translation Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Chemokine Production Positive Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Proliferation Cellular Response To Amino Acid Starvation Response To Interferon-alpha Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Viral Genome Replication Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Antiviral Innate Immune Response Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Hematopoietic Stem Cell Differentiation
Pathways		Neutrophil degranulation PKR-mediated signaling	ISG15 antiviral mechanism Inhibition of PKR SUMOylation of immune response proteins Interferon alpha/beta signaling Evasion by RSV of host interferon responses PKR-mediated signaling
Drugs			Indomethacin H-89 Fostamatinib
Diseases
GWAS			Glucose homeostasis traits ( 25524916) Platelet count ( 32888494)
Interacting Genes		22 interacting genes: CCNDBP1 CEBPA DYNLT1 EEF1G EIF2AK2 EP300 ERG EXOSC8 H19 IL7R INCA1 IQGAP1 KRTAP6-3 MEOX2 OGT PICK1 PRKDC PTEN SGSM2 SREK1 TRIM27 ZMYND12	131 interacting genes: ADARB1 CAPRIN1 CASP3 CASP7 CASP8 CDC42 CHUK DHX58 DICER1 DNAJC3 EDC4 EIF2A EIF2S1 EIF6 ELF2 FTSJ3 H2AC20 H2AC4 HSP90AA1 HSPA1A IKBKB IL7R ILF2 ILF3 JAK1 LINC00624 MAP2K6 MAP3K5 MAP3K7 MAVS METAP2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NCK1 NEIL3 NFKBIA NPM1 OGT PA2G4 PDGFRB PPP1CA PPP1CC PPP2R5A PRKRA PRKRIP1 PTGES3 RAC1 RPL18 SPIDR STAT1 STAT3 STRBP SUMO1 TAB2 TARBP2 THAP12 TIRAP TP53 TYK2 UBE2I ZNF346
Entrez ID		3608	5610
HPRD ID		04419	01468
Ensembl ID		ENSG00000143621	ENSG00000055332
Uniprot IDs		B4DY09 F4ZW62 Q12905 Q53FG3	A0A7P0Z4M0 P19525 Q8IW76
PDB IDs			1QU6 2A19 2A1A 3UIU 6D3K 6D3L 7OBK 7OBL 8BI7 8I9J 8IZN
Enriched GO Terms of Interacting Partners?		STAT Family Protein Binding Regulation Of Phosphorus Metabolic Process Negative Regulation Of Phosphate Metabolic Process Protein Domain Specific Binding Chromatin DNA Binding Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Biosynthetic Process Leukocyte Differentiation Nucleoplasm Defense Response Positive Regulation Of RNA Biosynthetic Process Response To Nutrient Levels Positive Regulation Of Gene Expression Regulation Of Cell Development Negative Regulation Of Cell Cycle Cell Development Mononuclear Cell Differentiation Positive Regulation Of DNA-templated Transcription RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Identical Protein Binding Positive Regulation Of Transcription By RNA Polymerase II Cytoplasm Protein Modification Process T Cell Lineage Commitment Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Peptidyl-lysine Propionylation Histone Acetyltransferase Complex Protein-DNA Complex Regulation Of Protein Modification Process Swimming Histone Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Lymphocyte Differentiation Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Cellular Response To Nutrient Levels Circadian Rhythm Histone Crotonyltransferase Activity Rhythmic Process Phosphorylation Protein Phosphorylation T Cell Differentiation In Thymus Neuron Projection Regulation Of Hematopoietic Progenitor Cell Differentiation Negative Regulation Of Phosphorylation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Protein Phosphorylation	RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Metabolic Process Negative Regulation Of Translation Extracellular Vesicle Regulation Of Translation Negative Regulation Of Cytokine Production Negative Regulation Of Cell Migration Regulation Of Cytokine Production MRNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Motility RNA Destabilization Negative Regulation Of Protein Metabolic Process Negative Regulation Of Locomotion Regulation Of Angiogenesis Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Vasculature Development Negative Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Regulation Of Cell Migration Regulation Of RNA Stability Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Cell Motility Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Locomotion Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Developmental Process
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