IL13RA1 and IL4R

Number of citations: 0 (PubMedID 8910586)
Data Source: HPRD (in vivo, in vitro)

		IL13RA1	IL4R
Name		interleukin 13 receptor subunit alpha 1	interleukin 4 receptor
Structure
GO Annotations	Cellular Component	Plasma Membrane Interleukin-13 Receptor Complex External Side Of Plasma Membrane Membrane Receptor Complex	Extracellular Region Nucleoplasm Plasma Membrane External Side Of Plasma Membrane Membrane Centriolar Satellite Receptor Complex
	Molecular Function	Cytokine Receptor Activity Protein Binding Cytokine Binding	Cytokine Receptor Activity Interleukin-4 Receptor Activity Protein Binding
	Biological Process	Positive Regulation Of Immunoglobulin Production Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway	Immune System Process Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Positive Regulation Of Chemokine Production Interleukin-4-mediated Signaling Pathway Defense Response To Protozoan Positive Regulation Of Macrophage Activation Positive Regulation Of Mast Cell Degranulation T-helper 1 Cell Differentiation T-helper 2 Cell Differentiation Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Myoblast Fusion
Pathways		Interleukin-4 and Interleukin-13 signaling	Interleukin-4 and Interleukin-13 signaling
Drugs		None	AER001 Dupilumab
Diseases		None	Asthma
GWAS		Body mass index ( 28892062 ) Type 2 diabetes ( 30718926 )	Asthma ( 34103634 32296059 31959851 31619474 31361310 30929738 ) Asthma (adult onset) ( 30929738 ) Asthma (childhood onset) ( 30929738 31036433 ) Asthma (time to onset) ( 27130862 ) Asthma onset (childhood vs adult) ( 30929738 ) Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of white cells ( 27863252 32888494 ) IgE levels ( 22075330 ) Leprosy ( 27976721 ) Medication use (adrenergics, inhalants) ( 31015401 ) Night sleep phenotypes ( 27126917 ) Primary biliary cholangitis ( 28425483 26394269 ) Self-reported allergy ( 23817569 ) Serum IgE levels ( 25488688 ) Sum eosinophil basophil counts ( 27863252 )
Novel Interactors		None recorded	5 novel interactors: ERN2 HDGFL3 NPIPB5 RBBP6 SLC20A1
Interacting Genes		7 interacting genes: DLG4 IL13 IL4R TMEM132D TMEM39B TRAF3IP1 TYK2	23 interacting genes: ARIH2 CD40 DOK2 FES HGS IL13 IL13RA1 IL13RA2 IL2RG IL4 INPP5D IRS1 IRS2 JAK1 JAK2 JAK3 PRKCZ PTPN11 PTPN6 RACK1 SHC1 SOCS5 STAT6
Entrez ID		3597	3566
HPRD ID		02125	00990
Ensembl ID		ENSG00000131724	ENSG00000077238
Uniprot IDs		P78552	B2RBY1 P24394
PDB IDs		3BPN 3BPO 4HWB 5E4E	1IAR 1IRS 3BPL 3BPN 3BPO 5E4E 6OEL 6WGL 8K4Q
GO Terms Enriched among Interactors		Positive Regulation Of Macrophage Activation Positive Regulation Of Mast Cell Degranulation Regulation Of Mast Cell Degranulation P2Y1 Nucleotide Receptor Binding Positive Regulation Of Lymphocyte Activation Regulation Of Cytokine Production Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Immunoglobulin Production Regulation Of Macrophage Activation Positive Regulation Of Alpha-beta T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Lung Goblet Cell Differentiation Positive Regulation Of Pancreatic Stellate Cell Proliferation Interleukin-13 Receptor Binding Negative Regulation Of Lung Ciliated Cell Differentiation Cytokine-mediated Signaling Pathway Regulation Of Immunoglobulin Production Positive Regulation Of Exocytosis Response To Other Organism Positive Regulation Of Cold-induced Thermogenesis Interleukin-4 Receptor Activity Positive Regulation Of Cytokine Production Regulation Of Lymphocyte Activation Beta-1 Adrenergic Receptor Binding Regulation Of Grooming Behavior Regulation Of Vesicle-mediated Transport Response To External Biotic Stimulus Regulation Of Alpha-beta T Cell Activation Regulation Of Regulated Secretory Pathway Interleukin-13-mediated Signaling Pathway Interleukin-12 Receptor Complex Negative Regulation Of T-helper 1 Cell Differentiation Regulation Of Cold-induced Thermogenesis Regulation Of Cell Activation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Interleukin-23 Receptor Complex AMPA Glutamate Receptor Clustering Neuroligin Family Protein Binding Negative Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Leukocyte Proliferation Transforming Growth Factor Beta1 Production Regulation Of Multicellular Organismal Process NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Exocytosis Interleukin-23-mediated Signaling Pathway Positive Regulation Of NK T Cell Proliferation Morphogenesis Of A Polarized Epithelium D1 Dopamine Receptor Binding Regulation Of Production Of Molecular Mediator Of Immune Response	Cytokine-mediated Signaling Pathway Positive Regulation Of Lymphocyte Activation Interleukin-4-mediated Signaling Pathway Regulation Of Lymphocyte Activation Positive Regulation Of Cell Activation Regulation Of Cell Activation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Production Of Molecular Mediator Of Immune Response Regulation Of B Cell Activation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Immunoglobulin Production Cell Surface Receptor Signaling Pathway Positive Regulation Of B Cell Activation Positive Regulation Of Immune System Process Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Immune Effector Process Regulation Of Immune System Process Regulation Of Leukocyte Proliferation Positive Regulation Of Immunoglobulin Production Regulation Of Multicellular Organismal Development Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Adaptive Immune Response Signal Transduction Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Multicellular Organismal Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Positive Regulation Of Developmental Process Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Cytokine Production Insulin Receptor Binding Regulation Of Lymphocyte Differentiation Growth Hormone Receptor Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Cell-cell Adhesion Regulation Of B Cell Proliferation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Leukocyte Activation Positive Regulation Of T Cell Activation Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Regulation Of Type 2 Immune Response Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell Adhesion Regulation Of Hemopoiesis Regulation Of Macromolecule Biosynthetic Process